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OHHNCH 3Cl(CH 2 )nSNNR 2R 1N H 2NSRR1= 2,6-(Cl) 2 , 4-F R=Ph,Me,CO 2 Me,CONMe 2 ,CONEt 2R2=4-OCH 3 ,4-NO 2 , 4-CN, 4-Br(37) (38)A family of tri substituted pyrimidines has been described as selectiveCOX- 2 inhibitors. To explore the usefulness of pyrimidine derivatives aspotential NSAIDs. Aurelio Orjales et al. 297 have synthesized novel pyrimidinederivatives(39) and (40). In vitro biological evaluation of these compounds hasprovided information to determine the structural features necessary for COX-2inhibitory activity.RH 3 CCH 3YZNXSR 1NNHMeO 2 SMeO 2 S(39) Y = CH; X, Z = N (40) Y, Z = N; X = CH61Pyrimidine…..