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fluorouracil (FU) showing good antitumour activity includes it’s1-t-butyl carbamoyl 262 , 1-hexylcarbamoyl 263 and 1-methoxycarbonylmethylcarbamoyl 264 derivatives, 5’- deoxy-5-fluorouridine 265 and methyl-1-(5-fluoro-1-H-2-oxopyrimidin- 4- yl)-BD- glucopyranuronate (21). 266 All of these containin essence the fluorouracil (FU) moiety, ready via oxidative or hydrolytic means.5-Fluoropyrimidin-4(1H)-one, with activity against tumours in experimentalanimals, is a different type of prodrug, being oxidized to 5-fluorouracil (FU) byxanthine oxidase. 267A number of prodrugs of FUdR have also been prepared a notably potentmember being 5-bromo-6-methoxydihydro-5-fluro-2’-deoxyuridine (22). 268Finally, a different species of fluoropyrimidine derivative, which as its 5’ monophosphate inhibits thymixylate synthetase is 5-trifluoromethyl-2’-deoxyuridine( Trifluridine); (23) it possesses a higher therapeutic index againstadenocar-cinoma 755 in mice than 2’-deoxyribo-nucleoside (FUdR;Floxuridine). 269NOFHOOOHNONBrFHOCH 3HOOOHNONCF 3NHHOHO(21) (22)(23)As part of a continuing effort of develop novel classical antifolates asdihydrofolates (DHFR) inhibitors and as antitumor agents, A. Gangjee et al. 27054Pyrimidine…..