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INTRODUCTIONCyclohexenone is the parent of a series of compounds that is important inagricultural and medicinal chemistry. Cyclohexenones are derivatives of cyclohexane with carbonyl group at 1-position and double bond at 2-position (I).Cyclohexenones can be conveniently synthesised by the treatment of α,β -unsaturated carbonyl compounds with ethylacetoacetate in basic media.O( I )In recent years cyclohexenone derivatives have gained lots of interestbecause of its prominent pharmaceutical properties.SYNTHETIC ASPECTDifferent methods for the synthesis of cyclohexenone derivatives have beendescribed in literature. 355-3611. N. Nanjundaswami et al. 362 have prepared 6,7-dimethoxy-1-aryl-4-oxo-2-naphthoate derivatives (III) by the reaction of dimethoxyphenyl aryl ketonewith diethyl succinate in presence of t-potassium butoxide.H 3 COH 3 COROCOOEtCOOEtt-BuOKH 3 COH 3 COORCOOEt(III)102Cyclohexenone…..
2. Michael addition of chalcone with active methylene compound such asdiethyl malonate, nitro methane and ethyl aceto acetate catalyzed bypotassium hydroxide in anhydrous ethanol results Michael adducts in75–98% yield under ultrasound irradiation in 25–90 min. 363XX+R 1OKOHEthanolat 25-30°CEtOOCR 2OMECHANISMRCH 3 R+ CHCH -OACH 3OC H 3OCOOEtCH 3R CH +A + H + + OHO-C H 3CH - COOEtBRCH 3 RO -H2OEtOOC CH 3 EtOOCO+H +CH 3EtOOC CH - CH 3OOO103Cyclohexenone…..
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The Sarvodaya Education Society’s
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selfless help, moral support and gu
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Introduction and Spectral studies .
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“STUDIES ON SOME HETEROCYCLICENTI
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Pyrimidine derivatives have been pr
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Isoxazole derivative synthesized by
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“STUDIES ON SOMEHETEROCYCLIC ENTI
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(b) Pharmacokinetics: It is derived
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(C) Drug DevelopmentMany natural pr
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The process of drug design is exten
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(l) Non steroidal anti-inflammatory
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INTRODUCTIONThe aza-indolizine cont
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PHARMACEUTICAL IMPORTANTMuch resear
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Compd. R 1 R 2 R 3a :- H 7-Me-6,8-B
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S. Kristjan, Gudmundsson and A. Bra
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STUDIES ON IMIDAZOPYRIDINE DERIVATI
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(a) Chalcones with monoethanolamine
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Das B.P. et al. 111 have found that
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Furthermore, Alcaraz M.J, et al. 13
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REACTION SCHEMECl+ClOClOClClCH 3NH
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Instrument : SHIMADZU FTIR 8400 Spe
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SignalNo.SignalPosition(δppm)Relat
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ANTIMICROBIAL ACTIVITYProducts : Ch
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The reaction mixture was poured on
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TABLE NO.- 1A BIOLOGICAL SCREENING
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PART-IISTUDIES ON PYRIMIDINES
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The self consistent (pi)electron de
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class of dye viz. trichloro pyrimid
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ability to cleave nucleic acid targ
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SSNHNHoONOoONOo(11) (12)oOHThe Pyri
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called ABPP or bropirimine(2-amino-
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acid so that it could be utilized f
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Page 71 and 72: maturation of the viral mRNA molecu
Page 73 and 74: Nevertheless, these compounds const
Page 75 and 76: OHHNCH 3Cl(CH 2 )nSNNR 2R 1N H 2NSR
Page 77 and 78: SECTION-ISTUDIES ONOXOPYRIMIDINES
Page 79 and 80: PHARMACEUTICAL IMPORTANCEIn recent
Page 81 and 82: REACTION SCHEMECH 3NNCHOCl10% KOH R
Page 83 and 84: INSTRUMENT :SHIMADZU FTIR 8400 Spec
Page 85 and 86: SignalNo.SignalPosition(δppm)Relat
Page 87 and 88: EXPERIMENTALSynthesis and therapeut
Page 89 and 90: TABLE NO.- 2(IB)PHYSICAL CONSTANTS
Page 91 and 92: INTRODUCTIONThiopyrimidine derivati
Page 93 and 94: H 3 COHNRH 3 CH 3 CNHS( IV ) R = ar
Page 95 and 96: SYNTHESIS AND THERAPEUTIC EVALUATIO
Page 97 and 98: IR SPECTRAL STUDIES OF 6-(2-(4-CHLO
Page 99 and 100: NMR SPECTRAL STUDIES OF 6-(2-(4-CHL
Page 101 and 102: MASS SPECTRAL STUDIES OF 6-(2-(4-CH
Page 103 and 104: [F] Antimicrobial activity of 6-(2-
Page 105 and 106: SECTION-IIISTUDIES ONAMINOPYRIMIDIN
Page 107 and 108: ArCHO+ArCOCH3NaOHMethanolR R 1ONaOH
Page 111 and 112: IR SPECTRAL STUDIES OF 4-(2-(4-CHLO
Page 113 and 114: NMR SPECTRAL STUDIES OF 4-(2-(4-CHL
Page 115 and 116: MASS SPECTRAL STUDIES OF 4-(2-(4-CH
Page 117 and 118: [F] Antimicrobial activity of 4-(2-
Page 119: PART-IIISTUDIES ONCYCLOHEXENONES
Page 123 and 124: Rheinheimer J. et al. 381have synth
Page 127 and 128: IR SPECTRAL STUDIES OF ETHYL-6-(2-(
Page 129 and 130: NMR SPECTRAL STUDIES OF ETHYL-6-(2-
Page 131 and 132: MASS SPECTRAL STUDIES OF ETHYL-6-(2
Page 133 and 134: Antimicrobial testing was carried o
Page 135 and 136: PART-IVSTUDIES ON PYRAZOLINES
Page 137 and 138: H 2 C= CHCN + Ar - NHNH 2NArN(3) 2
Page 139 and 140: PHARMACEUTICAL IMPORTANCE :2- Pyraz
Page 141 and 142: Kadu et al. 424 and antimicrobial b
Page 143 and 144: REACTION SCHEMECH 3NNClCHO10% KOHRO
Page 145 and 146: Instrument : SHIMADZU FTIR 8400 Spe
Page 147 and 148: SignalNo.SignalPosition(δppm)Relat
Page 149 and 150: EXPERIMENTALSynthesis and therapeut
Page 151 and 152: TABLE NO.- 4(B)PHYSICAL CONSTANTS O
Page 153 and 154: INTRODUCTION:Isoxazole come under t
Page 155 and 156: PHARMACEUTICAL IMPORTANCE :Isoxazol
Page 157 and 158: SYNTHESISAND THERAPEUTIC EVALUATION
Page 159 and 160: IR SPECTRAL STUDIES OF 2-(4-CHLOROP
Page 161 and 162: NMR SPECTRAL STUDIES OF 2-(4-CHLORO
Page 163 and 164: MASS SPECTRAL STUDIES OF 2-(4-CHLOR
Page 165 and 166: [F]Antimicrobial activity of 2-(4-c
Page 167 and 168: PART-VISTUDIES ON OXIRANES
Page 169 and 170: ( iii ) Epoxidation can also been c
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Moreover, Nomura Yutaka et al. 487
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SYNTHESIS AND THERAPEUTIC EVALUATIO
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IR SPECTRAL STUDIES OF (3-(2-(4-CHL
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NMR SPECTRAL STUDIES OF (3-(2-(4-CH
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MASS SPECTRAL STUDIES OF (3-(2-(4-C
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[F] Antimicrobial activity of (3-(2
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1. J. A. Joule and K. Mills; Hetero
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37. James J. Kaminski, D. G. perkin
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78. Ms. B. S. Hastak and B. J. Ghiy
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116. V. R. Mudalir and V. Joshi ; I
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150. S. Inoue, A. J. Saggimoto and
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197. S. S. Bahekar, D. B. Shinde; A
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238. A. Kreutzberger and M. Sellhei
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280. See, for example, W. H. Prusof
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326. C. W. Whitehead and J. J. Trav
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366. Nagarjan K., Shenoy S. J.; Ind
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396. Ausra Voskiene,Vytautas Mickev
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432. Solankee Sejal; Prajapati Yoge
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463. Mishra Ashutosh ; Jain Sanmati
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496. Kaneko Mashami, Saitoh Yutaka,
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CH 3CH 3NNClNNClORHNONRRRC 6 H 5 -
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CH 3CH 3NNClNNClEtOOCORHNNRRRC 6 H
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