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The reaction mixture was poured on to crushed ice followed by neutralizationusing sodium bicarbonate. Crude product was isolated and crystallized from DMF.Yield 80% (2.34gm) ; m.p.179 °C ; (C 15 H 11 N 2 OCl ; Found : C,66.63%;H,4.18%;N,10.43 ; Required : C,66.55%;H,4.10%;N,10.35%)TLC solvent system : Ethyl acetate : Hexane ( 4:6)[D]Preparation of (2Z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl]-1-(4-methoxyphenyl)prop-2-en-1-one.A mixture 2-(4-chlorophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde(2.70gm,0.01m) and 1-(4-methoxyphenyl)ethanone (1.50gm,0.01m) was refluxed inmethanol for 6 hrs. NaOH is used as catalyst. The contents were poured on tocrushed ice and product isolated was crystallized from di-chloromethane. Yield 75%(3.01gm) ; m.p. 189 °C ; (C 24 H 19 N 2 O 2 Cl; Found : C,71.29%;H,4.52%;N,6.69% ;Required : C,71.55%;H,4.75%;N,6.95%)TLC solvent system : Ethyl acetate : Hexane ( 4:6)Similarly, other Chalcone derivatives have been obtained. The physical dataare recorded in Table No.- 1(B).[E] Antimicrobial activity of (2Z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one.All the products have been evaluated for antimicrobial activity as describedas under.(a)Antimicrobial activityIt was carried out by cup- plate diffusion method which has been describedas under.38Chalcone…..