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SYNTHESIS AND THERAPEUTIC EVALUTION OF (2Z)-3-[2-(4-CHLOROPHENYL)-8-METHYL IMIDAZO[1,2-a]PYRIDINE-3-YL]-1-ARYL PROP-2-EN-1-ONE.Chalcone derivatives have been found to be associated with variouspharmacological activities. These finding encouraged as to synthesize, some newnovel synthesis. (2Z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one derivatives Type-I synthesized by the condensation of2-(4-chlorophenyl)-6-methyl imidazo[1,2-a]pyridine-3-carbaldehyde with varioussubstituted ketone in methanol.CH 3ONNClRR= ArylType-IThe constitution of the synthesized products have been characterizedby using elemental analyses, infrared and 1 H-nucleur magnetic resonancespectroscopy and further supported by mass spectroscopy.All the products have been screened for their in vitro biological assay likeantimicrobial activity towards Gram positive and Gram negative bacterial strainsand antifungal activity toward Aspergillus niger at a concentration of 40μg/ml.Thebiological activities of the synthesized compound were compared with standarddrugs. The detail have been cited in Part-I Experimental - (E).29Chalcone…..