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Looking at their versatile therapeutic importance and with an aim to getting betterdrug. It was considered worthwhile to synthesized some new pyrazoline.CH 3NNClHNNRWhere,R=ArylThe preparation of 2-(4-chlorophenyl)-3-(4,5-dihydro-3-aryl-1H-pyrazol-5-yl)-8-methyl-1H-imidazo[1,2-a]pyridine derivatives has been undertaken by the cyclocondensationof chalcone with hydrazine hydrate and glacial acetic acid.PART-V :SYNTHESIS OF 2-(4-CHLOROPHENYL)-3-(3-ARYL ISOXAZOLE-5-YL)-8-METHYL-1H-IMIDAZO[1,2-a]PYRIDINE.Isoxazole have been found to be associated with broad spectrum of biologicalactivities like antibacterial, antifungal, insecticidal, anesthetic, analgesic andantidaibetic.CH 3NNClONRWhere,R=Aryl4Synopsis…..
Isoxazole derivative synthesized by the reaction of (2Z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one and hydroxylamine hydrochloride in ethanol containing sodium hydroxide was refluxed for 11hrs,the product was isolated by pouring the alcoholic solution on to crushed ice, thenfiltered, dried it.PART-VI : SYNTHESIS OF (3-(2-(4-CHLOROPHENYL)-8-METHYL-1H- IMIDAZO[1,2-a]PYRIDINE-3-YL)OXIRANE-2-YL) ARYL METHANONE.Oxirane derivatives have been reported to possess various pharmacologicalactivities like antibacterial, antifungal etc. In order to achive better potency, we havesynthesized oxirane derivatives.CH 3NNClOORWhere,R=ArylOxirane or Epoxide derivatives synthesized by the reaction of (2Z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl]-1-arylprop-2-en-1-one in mixtureof acetone and methanol with 8% aqueous sodium hydroxide followed by additionof 30% hydrogen peroxide, the solution was shaken and heated to the boiling pointfor 1h, then allowed to stand overnight at room temperature, then water was addedin the solution was extracted with ether. The ether layer was evaporated to giveEpoxide derivative compound.5Synopsis…..
Page 3: The Sarvodaya Education Society’s
Page 6 and 7: selfless help, moral support and gu
Page 9 and 10: Introduction and Spectral studies .
Page 11 and 12: “STUDIES ON SOME HETEROCYCLICENTI
Page 13: Pyrimidine derivatives have been pr
Page 17 and 18: “STUDIES ON SOMEHETEROCYCLIC ENTI
Page 19 and 20: (b) Pharmacokinetics: It is derived
Page 21 and 22: (C) Drug DevelopmentMany natural pr
Page 23 and 24: The process of drug design is exten
Page 25 and 26: (l) Non steroidal anti-inflammatory
Page 27 and 28: INTRODUCTIONThe aza-indolizine cont
Page 29 and 30: PHARMACEUTICAL IMPORTANTMuch resear
Page 31 and 32: Compd. R 1 R 2 R 3a :- H 7-Me-6,8-B
Page 33 and 34: S. Kristjan, Gudmundsson and A. Bra
Page 35 and 36: STUDIES ON IMIDAZOPYRIDINE DERIVATI
Page 37 and 38: (a) Chalcones with monoethanolamine
Page 39 and 40: Das B.P. et al. 111 have found that
Page 41 and 42: Furthermore, Alcaraz M.J, et al. 13
Page 43 and 44: REACTION SCHEMECl+ClOClOClClCH 3NH
Page 45 and 46: Instrument : SHIMADZU FTIR 8400 Spe
Page 47 and 48: SignalNo.SignalPosition(δppm)Relat
Page 49 and 50: ANTIMICROBIAL ACTIVITYProducts : Ch
Page 51 and 52: The reaction mixture was poured on
Page 53 and 54: TABLE NO.- 1A BIOLOGICAL SCREENING
Page 55 and 56: PART-IISTUDIES ON PYRIMIDINES
Page 57 and 58: The self consistent (pi)electron de
Page 59 and 60: class of dye viz. trichloro pyrimid
Page 61 and 62: ability to cleave nucleic acid targ
Page 63 and 64: SSNHNHoONOoONOo(11) (12)oOHThe Pyri
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called ABPP or bropirimine(2-amino-
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acid so that it could be utilized f
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have reported the 5-substitutedfuro
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maturation of the viral mRNA molecu
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Nevertheless, these compounds const
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OHHNCH 3Cl(CH 2 )nSNNR 2R 1N H 2NSR
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SECTION-ISTUDIES ONOXOPYRIMIDINES
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PHARMACEUTICAL IMPORTANCEIn recent
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REACTION SCHEMECH 3NNCHOCl10% KOH R
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INSTRUMENT :SHIMADZU FTIR 8400 Spec
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SignalNo.SignalPosition(δppm)Relat
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EXPERIMENTALSynthesis and therapeut
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TABLE NO.- 2(IB)PHYSICAL CONSTANTS
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INTRODUCTIONThiopyrimidine derivati
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H 3 COHNRH 3 CH 3 CNHS( IV ) R = ar
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SYNTHESIS AND THERAPEUTIC EVALUATIO
Page 97 and 98:
IR SPECTRAL STUDIES OF 6-(2-(4-CHLO
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NMR SPECTRAL STUDIES OF 6-(2-(4-CHL
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MASS SPECTRAL STUDIES OF 6-(2-(4-CH
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[F] Antimicrobial activity of 6-(2-
Page 105 and 106:
SECTION-IIISTUDIES ONAMINOPYRIMIDIN
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ArCHO+ArCOCH3NaOHMethanolR R 1ONaOH
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Page 111 and 112:
IR SPECTRAL STUDIES OF 4-(2-(4-CHLO
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NMR SPECTRAL STUDIES OF 4-(2-(4-CHL
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MASS SPECTRAL STUDIES OF 4-(2-(4-CH
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[F] Antimicrobial activity of 4-(2-
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PART-IIISTUDIES ONCYCLOHEXENONES
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2. Michael addition of chalcone wit
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Rheinheimer J. et al. 381have synth
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Page 127 and 128:
IR SPECTRAL STUDIES OF ETHYL-6-(2-(
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NMR SPECTRAL STUDIES OF ETHYL-6-(2-
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MASS SPECTRAL STUDIES OF ETHYL-6-(2
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Antimicrobial testing was carried o
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PART-IVSTUDIES ON PYRAZOLINES
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H 2 C= CHCN + Ar - NHNH 2NArN(3) 2
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PHARMACEUTICAL IMPORTANCE :2- Pyraz
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Kadu et al. 424 and antimicrobial b
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REACTION SCHEMECH 3NNClCHO10% KOHRO
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Instrument : SHIMADZU FTIR 8400 Spe
Page 147 and 148:
SignalNo.SignalPosition(δppm)Relat
Page 149 and 150:
EXPERIMENTALSynthesis and therapeut
Page 151 and 152:
TABLE NO.- 4(B)PHYSICAL CONSTANTS O
Page 153 and 154:
INTRODUCTION:Isoxazole come under t
Page 155 and 156:
PHARMACEUTICAL IMPORTANCE :Isoxazol
Page 157 and 158:
SYNTHESISAND THERAPEUTIC EVALUATION
Page 159 and 160:
IR SPECTRAL STUDIES OF 2-(4-CHLOROP
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NMR SPECTRAL STUDIES OF 2-(4-CHLORO
Page 163 and 164:
MASS SPECTRAL STUDIES OF 2-(4-CHLOR
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[F]Antimicrobial activity of 2-(4-c
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PART-VISTUDIES ON OXIRANES
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( iii ) Epoxidation can also been c
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Moreover, Nomura Yutaka et al. 487
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Page 175 and 176:
IR SPECTRAL STUDIES OF (3-(2-(4-CHL
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NMR SPECTRAL STUDIES OF (3-(2-(4-CH
Page 179 and 180:
MASS SPECTRAL STUDIES OF (3-(2-(4-C
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[F] Antimicrobial activity of (3-(2
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1. J. A. Joule and K. Mills; Hetero
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37. James J. Kaminski, D. G. perkin
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78. Ms. B. S. Hastak and B. J. Ghiy
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116. V. R. Mudalir and V. Joshi ; I
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150. S. Inoue, A. J. Saggimoto and
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197. S. S. Bahekar, D. B. Shinde; A
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238. A. Kreutzberger and M. Sellhei
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280. See, for example, W. H. Prusof
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326. C. W. Whitehead and J. J. Trav
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366. Nagarjan K., Shenoy S. J.; Ind
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396. Ausra Voskiene,Vytautas Mickev
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432. Solankee Sejal; Prajapati Yoge
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463. Mishra Ashutosh ; Jain Sanmati
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496. Kaneko Mashami, Saitoh Yutaka,
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CH 3CH 3NNClNNClORHNONRRRC 6 H 5 -
Page 214 and 215:
CH 3CH 3NNClNNClEtOOCORHNNRRRC 6 H
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