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The reaction monitoring of the all compounds done by thin layerchromatography using two different solvent systems (Rf 1 & Rf 2 ).The constitution ofnewly synthesized compounds have been delineated by elemental analysis,FT-IR, 1 H NMR and Mass spectroscopy.The compounds have been screened for their in vitro therapeutic assay likeantibacterial activities towards Gram positive and Gram negative bacterial strainand antifungal activity towards fungal strain at different concentration (MinimumInhibitory Concentration).The biological activities of synthesized compounds havebeen compared with standard drugs at different concentrations.6Synopsis…..
“STUDIES ON SOMEHETEROCYCLIC ENTITIESOF MEDICINAL INTEREST”GGHGGGGGGHHHKKKLL
Page 3: The Sarvodaya Education Society’s
Page 6 and 7: selfless help, moral support and gu
Page 9 and 10: Introduction and Spectral studies .
Page 11 and 12: “STUDIES ON SOME HETEROCYCLICENTI
Page 13 and 14: Pyrimidine derivatives have been pr
Page 15: Isoxazole derivative synthesized by
Page 19 and 20: (b) Pharmacokinetics: It is derived
Page 21 and 22: (C) Drug DevelopmentMany natural pr
Page 23 and 24: The process of drug design is exten
Page 25 and 26: (l) Non steroidal anti-inflammatory
Page 27 and 28: INTRODUCTIONThe aza-indolizine cont
Page 29 and 30: PHARMACEUTICAL IMPORTANTMuch resear
Page 31 and 32: Compd. R 1 R 2 R 3a :- H 7-Me-6,8-B
Page 33 and 34: S. Kristjan, Gudmundsson and A. Bra
Page 35 and 36: STUDIES ON IMIDAZOPYRIDINE DERIVATI
Page 37 and 38: (a) Chalcones with monoethanolamine
Page 39 and 40: Das B.P. et al. 111 have found that
Page 41 and 42: Furthermore, Alcaraz M.J, et al. 13
Page 43 and 44: REACTION SCHEMECl+ClOClOClClCH 3NH
Page 45 and 46: Instrument : SHIMADZU FTIR 8400 Spe
Page 47 and 48: SignalNo.SignalPosition(δppm)Relat
Page 49 and 50: ANTIMICROBIAL ACTIVITYProducts : Ch
Page 51 and 52: The reaction mixture was poured on
Page 53 and 54: TABLE NO.- 1A BIOLOGICAL SCREENING
Page 55 and 56: PART-IISTUDIES ON PYRIMIDINES
Page 57 and 58: The self consistent (pi)electron de
Page 59 and 60: class of dye viz. trichloro pyrimid
Page 61 and 62: ability to cleave nucleic acid targ
Page 63 and 64: SSNHNHoONOoONOo(11) (12)oOHThe Pyri
Page 65 and 66: called ABPP or bropirimine(2-amino-
Page 67 and 68:
acid so that it could be utilized f
Page 69 and 70:
have reported the 5-substitutedfuro
Page 71 and 72:
maturation of the viral mRNA molecu
Page 73 and 74:
Nevertheless, these compounds const
Page 75 and 76:
OHHNCH 3Cl(CH 2 )nSNNR 2R 1N H 2NSR
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SECTION-ISTUDIES ONOXOPYRIMIDINES
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PHARMACEUTICAL IMPORTANCEIn recent
Page 81 and 82:
REACTION SCHEMECH 3NNCHOCl10% KOH R
Page 83 and 84:
INSTRUMENT :SHIMADZU FTIR 8400 Spec
Page 85 and 86:
SignalNo.SignalPosition(δppm)Relat
Page 87 and 88:
EXPERIMENTALSynthesis and therapeut
Page 89 and 90:
TABLE NO.- 2(IB)PHYSICAL CONSTANTS
Page 91 and 92:
INTRODUCTIONThiopyrimidine derivati
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H 3 COHNRH 3 CH 3 CNHS( IV ) R = ar
Page 95 and 96:
SYNTHESIS AND THERAPEUTIC EVALUATIO
Page 97 and 98:
IR SPECTRAL STUDIES OF 6-(2-(4-CHLO
Page 99 and 100:
NMR SPECTRAL STUDIES OF 6-(2-(4-CHL
Page 101 and 102:
MASS SPECTRAL STUDIES OF 6-(2-(4-CH
Page 103 and 104:
[F] Antimicrobial activity of 6-(2-
Page 105 and 106:
SECTION-IIISTUDIES ONAMINOPYRIMIDIN
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ArCHO+ArCOCH3NaOHMethanolR R 1ONaOH
Page 109 and 110:
Page 111 and 112:
IR SPECTRAL STUDIES OF 4-(2-(4-CHLO
Page 113 and 114:
NMR SPECTRAL STUDIES OF 4-(2-(4-CHL
Page 115 and 116:
MASS SPECTRAL STUDIES OF 4-(2-(4-CH
Page 117 and 118:
[F] Antimicrobial activity of 4-(2-
Page 119 and 120:
PART-IIISTUDIES ONCYCLOHEXENONES
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2. Michael addition of chalcone wit
Page 123 and 124:
Rheinheimer J. et al. 381have synth
Page 125 and 126:
Page 127 and 128:
IR SPECTRAL STUDIES OF ETHYL-6-(2-(
Page 129 and 130:
NMR SPECTRAL STUDIES OF ETHYL-6-(2-
Page 131 and 132:
MASS SPECTRAL STUDIES OF ETHYL-6-(2
Page 133 and 134:
Antimicrobial testing was carried o
Page 135 and 136:
PART-IVSTUDIES ON PYRAZOLINES
Page 137 and 138:
H 2 C= CHCN + Ar - NHNH 2NArN(3) 2
Page 139 and 140:
PHARMACEUTICAL IMPORTANCE :2- Pyraz
Page 141 and 142:
Kadu et al. 424 and antimicrobial b
Page 143 and 144:
REACTION SCHEMECH 3NNClCHO10% KOHRO
Page 145 and 146:
Instrument : SHIMADZU FTIR 8400 Spe
Page 147 and 148:
SignalNo.SignalPosition(δppm)Relat
Page 149 and 150:
EXPERIMENTALSynthesis and therapeut
Page 151 and 152:
TABLE NO.- 4(B)PHYSICAL CONSTANTS O
Page 153 and 154:
INTRODUCTION:Isoxazole come under t
Page 155 and 156:
PHARMACEUTICAL IMPORTANCE :Isoxazol
Page 157 and 158:
SYNTHESISAND THERAPEUTIC EVALUATION
Page 159 and 160:
IR SPECTRAL STUDIES OF 2-(4-CHLOROP
Page 161 and 162:
NMR SPECTRAL STUDIES OF 2-(4-CHLORO
Page 163 and 164:
MASS SPECTRAL STUDIES OF 2-(4-CHLOR
Page 165 and 166:
[F]Antimicrobial activity of 2-(4-c
Page 167 and 168:
PART-VISTUDIES ON OXIRANES
Page 169 and 170:
( iii ) Epoxidation can also been c
Page 171 and 172:
Moreover, Nomura Yutaka et al. 487
Page 173 and 174:
Page 175 and 176:
IR SPECTRAL STUDIES OF (3-(2-(4-CHL
Page 177 and 178:
NMR SPECTRAL STUDIES OF (3-(2-(4-CH
Page 179 and 180:
MASS SPECTRAL STUDIES OF (3-(2-(4-C
Page 181 and 182:
[F] Antimicrobial activity of (3-(2
Page 184 and 185:
1. J. A. Joule and K. Mills; Hetero
Page 186 and 187:
37. James J. Kaminski, D. G. perkin
Page 188 and 189:
78. Ms. B. S. Hastak and B. J. Ghiy
Page 190 and 191:
116. V. R. Mudalir and V. Joshi ; I
Page 192 and 193:
150. S. Inoue, A. J. Saggimoto and
Page 194 and 195:
197. S. S. Bahekar, D. B. Shinde; A
Page 196 and 197:
238. A. Kreutzberger and M. Sellhei
Page 198 and 199:
280. See, for example, W. H. Prusof
Page 200 and 201:
326. C. W. Whitehead and J. J. Trav
Page 202 and 203:
366. Nagarjan K., Shenoy S. J.; Ind
Page 204 and 205:
396. Ausra Voskiene,Vytautas Mickev
Page 206 and 207:
432. Solankee Sejal; Prajapati Yoge
Page 208 and 209:
463. Mishra Ashutosh ; Jain Sanmati
Page 210 and 211:
496. Kaneko Mashami, Saitoh Yutaka,
Page 212 and 213:
CH 3CH 3NNClNNClORHNONRRRC 6 H 5 -
Page 214 and 215:
CH 3CH 3NNClNNClEtOOCORHNNRRRC 6 H
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