Hormones 2016

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Chapter 8 Anti-androgens Bicalutamide What is it? Bicalutamide is an oral non-steroidal anti-androgen 44 . It binds to the androgen receptor and works by blocking the action of testosterone. Administration Oral, as tablets Also known as Casodex, Bicalutamid in Germany, and Bicalutamida in Spain. Manufacturer Zentiva, and Winthrop Pharmaceuticals. Contains Contents of one 50mg bicalutamide tablet - • Tablet core - Lactose monohydrate, Povidone K-29/32, Crospovidone (type A), Sodium lauryl sulphate, Magnesium stearate • Film-coating - Lactose monohydrate, Hypromellose, Titanium dioxide (E171), Macrogol 4000 (emc, 2016). 44 counteracts the effects of androgens on various body organs and tissues 124 Version 2016.3576– – Document LATEXed – 1st May 2016 [git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)
Bicalutamide Pharmacology Bicalutamide acts as a pure anti-androgen by binding to the androgen receptor (AR) and preventing the activation of the AR 45 and subsequent upregulation of androgen responsive genes by androgenic hormones (wikipedia, 2014a). Pharmacodynamics Bicalutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Bicalutamide is a pure, nonsteroidal antiandrogen with affinity for androgen receptors (but not for progestogen, oestrogen, or glucocorticoid receptors). Consequently, Bicalutamide blocks the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration (drugbank, 2013a). How it works Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue (drugbank, 2013a). Indications Used for treating prostate cancer, used in combination with a luteinizinghormone releasing hormone LHRH 46 analog (eg, goserelin, leuprolide). Also used to treat hirsutism (unknown, 2014a). Pharmacokinetics Half-Life - 5–8 days Peak plasma time - 31 hours Peak plasma concentration - 0.77 mcg/mL Protein Bound - 96% Excretion - Urine (36%), faeces (42%)(Medscape, 2014). 45 androgen receptor 46 luteinizing-hormone releasing hormone 125 Version 2016.3576– – Document LATEXed – 1st May 2016 [git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)
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Sharon Kimble (S.E.N.,R.G.N.) Hormo
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Contents Leuprorelin Acetate . . .
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Contents Sperm banking . . . . . .
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List of Tables 13.10Reference range
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List of Figures 3.1 Positive and ne
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This document understandable format
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About the author About the author M
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Chapter 2 README FIRST This chapter
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Cyproterone Acetate • nocturia,
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Dydrogesterone Common side-effects
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Estradiol Valerate Cardiovascular
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Goserelin Common side-effects Gastr
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Oestrogel Also known as Regaine, Ro
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Testosterone • oedema, (Abramovit
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Triptorelin Common side-effects Gas
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Chapter 3 Preamble What are hormone
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Side effects want to keep your weig
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What changes will I see? 9 You can
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What changes will I see? Changes to
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What changes will I see? Female-to-
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What changes will I see? Changes to
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What changes will I see? Effect Bod
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Common therapies Oestrogens, conjug
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Drugs used in Female to Male transi
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How oestrogen works DNA’s genetic
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Hormone effects in male→female
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Hormone effects in female→male
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Hormone effects in female→male Ga
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Hormone effects in female→male De
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An overview of the endocrine system
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The major endocrine glands Table 4.
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The Biochemistry of Sex Hormones Fi
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Page 75 and 76: Female Genital Anatomy • Epididym
Page 77 and 78: Female Genital Anatomy of the breas
Page 79 and 80: Chapter 6 Hormones Estradiol Valera
Page 81 and 82: Estradiol Valerate If you are signi
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Page 85 and 86: Estradiol Valerate Siltuximab - The
Page 87 and 88: Estradiol Valerate • Nausea, •
Page 89 and 90: Estradiol Valerate Metabolism - Est
Page 91 and 92: Oestrogel • Significant increase
Page 93 and 94: Oestrogel Interactions Drug interac
Page 95 and 96: Oestrogel • breast swelling, •
Page 97 and 98: Sandrena • A history of endometri
Page 99 and 100: Sandrena Breastfeeding Sandrena is
Page 101 and 102: Sandrena Psychiatric disorders •
Page 103 and 104: Testosterone Testosterone Administr
Page 105 and 106: Testosterone being. Examples includ
Page 107 and 108: Testosterone • Amenorrhoea, • o
Page 109 and 110: Testosterone Disopyramide - Testost
Page 111 and 112: Testosterone Effects on Lab Test Re
Page 113 and 114: Testosterone Schedule IV - Drugs th
Page 115 and 116: Dutasteride Contains Dutasteride 50
Page 117 and 118: Dutasteride Pharmacodynamics The on
Page 119 and 120: Finasteride Effects on Lab Test Res
Page 121 and 122: Finasteride Pharmacodynamics Finast
Page 123: Finasteride Patient Teaching Tell p
Page 127 and 128: Bicalutamide Hepatic Hepatic side e
Page 129 and 130: Bicalutamide Cisapride - The serum
Page 131 and 132: Cyproterone Acetate Administration
Page 133 and 134: Cyproterone Acetate How it works Th
Page 135 and 136: Cyproterone Acetate Estradiol - The
Page 137 and 138: Cyproterone Acetate Repaglinide - T
Page 139 and 140: Flutamide Note Should be taken afte
Page 141 and 142: Flutamide Interactions Drug-drug Wa
Page 143 and 144: Flutamide Contraindications Sensiti
Page 145 and 146: Goserelin Shelf life Drogenil = 60
Page 147 and 148: Goserelin Typical dosage Pre-op 3.6
Page 149 and 150: Goserelin • Sexual dysfunction,
Page 151 and 152: Goserelin Ciprofloxacin - Goserelin
Page 153 and 154: Goserelin Itraconazole - Itraconazo
Page 155 and 156: Goserelin Sorafenib - Sorafenib may
Page 157 and 158: Leuprorelin Acetate Self-care tips
Page 159 and 160: Leuprorelin Acetate which leads to
Page 161 and 162: Leuprorelin Acetate Anagrelide - Le
Page 163 and 164: Leuprorelin Acetate Flupentixol - L
Page 165 and 166: Leuprorelin Acetate Mifepristone -
Page 167 and 168: Leuprorelin Acetate Tacrolimus - Ta
Page 169 and 170: Triptorelin Triptorelin Alternative
Page 171 and 172: Triptorelin Insulin Regular - The t
Page 173 and 174: Triptorelin • anorexia, • gout,
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Triptorelin Distribution The volume
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Triptorelin The suspension vehicle
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Triptorelin • Triptorelin may rai
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Chapter 9 Progestogens Dydrogestero
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Dydrogesterone Pharmacodynamics Dyd
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Dydrogesterone Danaparoid - The the
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Progesterone Contains Cylcogest - P
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Progesterone • Fatigue, • heada
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Progesterone Bosentan - The serum c
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Progesterone Repaglinide - The ther
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Chapter 10 Other useful drugs This
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Emla Cream Slight erythema is frequ
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Emla Cream Typical dosage Electroly
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Minoxidil Warning Do not use near y
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Vaniqa Eflornithine is a prescripti
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Vaniqa Patients may need to continu
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Ethinylestradiol Contains Ethinyles
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Ethinylestradiol • Headache, •
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Ethinylestradiol Bortezomib - The m
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Ethinylestradiol Secobarbital - The
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Medroxyprogesterone Acetate Warning
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Medroxyprogesterone Acetate Route T
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Medroxyprogesterone Acetate Atazana
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Medroxyprogesterone Acetate Insulin
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Medroxyprogesterone Acetate Topiram
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Oestrogens, conjugated Action Mimic
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Oestrogens, conjugated Vaginal - cr
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Oestrogens, conjugated Cyclosporine
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Spironolactone Spironolactone - liq
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Spironolactone Contraindications Hy
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Spironolactone Chlorphenamine - The
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Spironolactone Racepinephrine - Spi
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Spironolactone Warning You should b
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Breast Self Examination can be succ
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Deep Vein Thrombosis - You should a
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Deep Vein Thrombosis Epidemiology
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Osteoporosis Treating a DVT Treatme
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Osteoporosis Your sex - Women are m
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Prostate cancer Height loss and ost
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Testicular Self Examination Figure
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Testicular Self Examination Signs o
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Urinary Tract Infections - UTI’s
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Urinary Tract Infections - UTI’s
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Blood testing What To Expect After
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Blood testing Production of red blo
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Blood testing Proper handling of th
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Blood groups Antigens and antibodie
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Alkaline phosphate - ALP Male Femal
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Blood Glucose High bilirubin levels
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Cholesterol HDL (Good) Cholesterol
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Cholesterol • Stroke, • Serious
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Dehydroepiandrosterone sulphate - D
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Dihydrotestosterone - DHT elevation
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Follicle stimulating hormone - FSH
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High-density lipoprotein - HDL In m
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Low-density lipoprotein - LDL relat
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Liver function tests Indications Th
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Luteinizing hormone - LH Other test
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Oestrogen Test Conventional SI Unit
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Prolactin - PRL Low oestrogen level
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Sex hormone binding globulin - SHBG
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Testosterone Test Conventional SI U
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Thyroxine, free - T4 Raised testost
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Blood, urea and nitrogen - BUN •
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Full Blood Count - FBC Mean corpusc
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Full Blood Count - FBC Lymphocytes
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Full Blood Count - FBC More commonl
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Full Blood Count - FBC High platele
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International Normalised Ratio - IN
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Prostate specific antigen - PSA •
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Prostate specific antigen - PSA Dig
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Thyroid function test - TFT Once ag
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Urine and electrolytes • collect
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Urine and electrolytes Normal Value
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Urine and electrolytes What abnorma
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Urine and electrolytes • Low magn
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Albumin What abnormal results mean
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Chapter 15 Sexually transmitted inf
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Chlamydia It’s passed on from one
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Chlamydia the eyes - if they come i
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Genital herpes Genital herpes Genit
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Genital herpes ⋆ vaginal discharg
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Genital herpes • If urinating is
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Genital warts • Use condoms (male
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Genital warts How will I know if I
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Genital warts Because HPV is spread
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Gonorrhoea Signs and symptoms You m
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Gonorrhoea Sometimes you may be ask
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Hepatitis You can always go back to
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Hepatitis • rimming • fingering
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Hepatitis • as a result of blood-
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Hepatitis • have close contact wi
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Hepatitis • jaundice, • mental
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HIV Why should I get treated? Hepat
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HIV A woman with HIV can transmit t
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HIV • people who have caught anot
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HIV An HIV test should only be done
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HIV • PEP is an emergency measure
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HIV Treatment is usually recommende
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Molluscum contagiosum Molluscum con
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Molluscum contagiosum When to seek
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Molluscum contagiosum The treatment
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Molluscum contagiosum Pulsed-dye la
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Pubic lice What are the signs and s
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Scabies Finding empty eggshells (de
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Scabies Scabies mites can survive o
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Shigella What should I do if I thin
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Syphilis Statistics for 2014 showed
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Syphilis The latent stage can conti
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Syphilis You will be prescribed ano
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Trichomoniasis How is it passed on?
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How to avoid sexually transmitted i
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Condoms Avoid other types of contac
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Condoms • If you are having anal
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Condoms Some men and women are sens
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Condoms Are there different types o
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Condoms Disadvantages • Some coup
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Condoms If you buy condoms online,
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Condoms • Now put your index or m
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Condoms Risks There are no serious
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Condoms Don’t use lotion or oils
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Bacterial vaginosis - BV Women with
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Bacterial vaginosis - BV The level
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Bacterial vaginosis - BV Things to
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Proctitis Proctitis Proctitis is so
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Thrush Symptoms • Irritation, bur
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Thrush It is very important to take
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Thrush Avoid Men should also try to
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Urethritis Urethritis Urethritis is
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Urethritis Other infections A numbe
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Urethritis You will be asked not to
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Urethritis NGU and sexually transmi
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Urethritis • epididymitis is infl
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Vaginal Thrush What to do if you ha
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Vaginal Thrush Emollients and antif
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Vaginitis • Pain when you wee,
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Accessing your health records • A
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Accessing your health records An at
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Adrenal Fatigue Symptoms said to be
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Adrenal Insufficiency Adrenal Insuf
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Bio-equivalence Product Presentatio
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Bio-equivalence Generic Brand Form
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Blood levels Active ingredient Bran
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Blood levels Hormone Female Male Bl
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Blood tests • SHBG, • testoster
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Blood tests Analyte Specimen Conven
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Blood tests Analyte Folliclestimula
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Blood tests Analyte •Content leve
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Body fat Analyte Specimen Conventio
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Breast Development Figure 17.2 - Th
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Breast disorders • As time passes
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Breast disorders Symptom Causes Com
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Breast disorders The breast is palp
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Breast disorders CBE is usually par
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Breast disorders Red flags Certain
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Breast disorders Nipple discharge c
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Breast disorders Cause Suggestive f
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Breast disorders the area around th
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Breast disorders Diffuse bilateral
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Breast Implants Saline implant rupt
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Breast Screening What is the NHS Br
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Breast Screening • some cancers a
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Coming out A personal experience. W
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Consent and Informed Consent Consen
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Cycling Hormones? thanks to its ant
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E-numbers Drug names Medicines norm
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Expiry dates What to do? There are
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Further discussion of Vitamin D Fac
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Gender expression) related to that
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Getting a urine sample or otherwise
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Grapefruit Juice • avoid cocaine,
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Grapefruit Juice Generic Brand Clin
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Heamatological Reference Values Ana
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How to Take Your Tablets. This last
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Implants, Testosterone and Estradio
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Infection? Labial redness variable
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Injections Syringe size Your syring
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Injections 4 Using your "Ampoule Op
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Injections 10 Where appropriate a
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Injections Figure 17.9 - This shows
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Kegel exercises Kegel exercises Fig
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Lactation the muscle for a count of
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Liver damage All products absorbed
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Male pregnancy root), preventing th
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Measuring Your Transition • Measu
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Menopause suggest a specific influe
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Menopause Male menopause Male menop
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Menopause Men normally experience a
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Menopausal symptoms Menopausal symp
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Mood swings and depression See also
Page 555 and 556:
Oestrogen and Alzheimer’s Disease
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Pelvic examination • manual, •
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Pharmacodynamics Pharmacodynamics T
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Premarin Premarin This drug is, sup
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Prescriptions Medical exemptions Pe
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Prostate cancer Prostate cancer The
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Regimes Hormone regimes for transge
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Regimes Name Dosage When taken OR 5
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Regimes Parenterally (i.m. or subcu
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Safety of HRT • Getting older,
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Sexual Health Dementia Evorel [estr
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Sexual Health Mammography Women sho
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Skin care Skin care One of the unfo
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Skin care Sensitive Skin Please not
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Skin care Sanitise your tools Wash
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Skin care • Lemon juice works wel
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Sleep more often reported a variety
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Sleep The stages of NREM sleep and
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Sleep Sleep fragmentation results f
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Smoking and taking hormones Many st
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Stopping hormones prior to surgery
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Stress management Stress management
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Stress management A single episode
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Stress management Reach out - Make
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Stress management Why you react to
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Stress management Reframe your thou
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Stress management • Stressing abo
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Stress management Try aromatherapy
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Stress management your mind as well
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Stretch marks Maintain healthy rela
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Supplies Supplies In the UK Nu-Care
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Testosterone replacement therapy, m
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The real side effects of testostero
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The real side effects of testostero
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The risks of breast cancer One stud
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Thrush "The FDA has reviewed the av
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Transgender Definitions 1 It can’
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Transgender Definitions Cross Dress
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Transgender Definitions Dyke This i
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Transphobia Transwoman A male-to-fe
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Transphobia When referring to trans
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Treatment aims • online abuse,
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Urinary Tract Infections 1 IU 45.5
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Vitality Children Vaginitis usually
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Vitamins Age Folate µg Niacin mg R
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Vitamins Deficiencies - Inadequate
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Vitamins Recommended Dietary Allowa
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Vitamins Food Sources - Avocado, ba
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What is a ’vitamin’? that contr
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Zoff Review the material again - Re
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Books Made In God’s Image: A Reso
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Email This site is strictly for MTF
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Some web sites Some web sites All l
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Chapter 19 Appendix 1 American vs B
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How to evaluate health information
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Glossary A | B | C | D | E | F | G
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Glossary cancerous malignant . . .
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Glossary G gastric lavage stomach w
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Glossary lipophilic the ability to
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Glossary spermatogenesis Spermatoge
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Acronyms A | B | C | D | E | F | G
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Acronyms HRT Hormone Replacement Th
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Bibliography [AB, 2011] CellaVision
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Bibliography [Beastall, Ferguson, O
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Bibliography [Burger, 2002] H. G. B
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Bibliography [Corona, Maseroli, Ras
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Bibliography [drugbank, 2014b] 2014
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Bibliography [Fogelman, 1991] L Fog
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Bibliography [Gossman, 2014] MV Gos
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Bibliography [helpguide, 2016b] 201
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Bibliography [L. Johnson, 2014] LE
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Bibliography [Kuper, Mantzoros, Lag
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Bibliography [Lippert, A. O. Mueck,
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Bibliography [mayoclinic, 2014c] 20
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Bibliography [MIMS, 2016a] MIMS 201
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Bibliography [NHS, 2014f] 2014f HIV
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Bibliography [O’Sullivan, 2013] M
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Bibliography [Rasgon, Geist, Kenna,
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Bibliography [Sabon, Cheng, Stommel
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Bibliography [takingcharge, 2010] t
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Bibliography [ucsfhealth, 2009b] 20
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Bibliography [unknown, 2015e] 2015e
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[wikipedia, 2016] 2016 Tanner scale
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Medroxyprogesterone Acetate 215 Oes
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interaction Carbamezapine . . . . .
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depressed mood . . . . . . . . . .
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liver failure . . . . . . . . . . .
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transient erythema . . . . . . . .
Page 735 and 736:
pancreatitis . . . . . . . . . . .
Page 737 and 738:
Vaniqa acne . . . . . . . . . . . .
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Aminophylline Cyproterone Acetate .
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Capromab Bicalutamide . . . . . . .
Page 743 and 744:
Nelfinavir . . . . . . . . . . . .
Page 745 and 746:
Edetic Acid Cyproterone Acetate . .
Page 747 and 748:
C1 Esterase Inhibitor (Human) 213 C
Page 749 and 750:
Leuprorelin Acetate . . . . . . . 1
Page 751 and 752:
Propofol . . . . . . . . . . . . .
Page 753 and 754:
Progesterone. . . . . . . . . . . .
Page 755 and 756:
Maprotiline . . . . . . . . . . . .
Page 757 and 758:
Glimepiride . . . . . . . . . . . .
Page 759 and 760:
Bicalutamide . . . . . . . . . . .
Page 761 and 762:
Goserelin . . . . . . . . . . . . .
Page 763 and 764:
Saxagliptin Cyproterone Acetate . .
Page 765 and 766:
Tasimelteon Cyproterone Acetate . .
Page 767 and 768:
Goserelin . . . . . . . . . . . . .
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Index of STI’s A Avoidance . . .
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Curettage . . . . . . . . . . . . .
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General Index A Accessing someone e
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What happens? . . . . . . . . . . .
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Importing hormones. . . . . . . . .
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S Safety of our regimes . . . . . .
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