Hormones 2016

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Oestrogens, conjugated factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, oestrogen is the primary determinant in the onset of menstruation. Oestrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated oestrogens are similar to those of endogenous oestrogens (drugbank, 2015a). Absorption - Well absorbed. Elimination - Estradiol, estrone, and estriol are excreted in the urine, along with glucuronide and sulfate conjugates. Exogenous oestrogens are metabolised in the same manner as endogenous oestrogens. Half-life - 7.4 hours (drugbank, 2015a). Indications Inoperable progressing prostate cancer, palliative treatment for metastatic breast cancer, hypogonadism 65 , castration, primary ovarian failure, vasomotor menopausal symptoms, moderate to severe menopausal vulvar and vaginal atrophy (Abramovitz, 2016). Pharmacokinetics Premarin is metabolised exclusively in the liver, utilises hepatic recirculation, and is excreted in the urine (Abramovitz, 2016). How it works Oestrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Oestrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of FSH and LH from the pituitary (drugbank, 2015a). Typical dosage Pre-op - 1.25–7.5 mgs/day (unknown, 2005), 5–10 mgs/day (Asscheman and LJG Gooren, 1992). Post-op - 0.625–3.75 mgs/day (unknown, 2005). Route Oral - tablets - Premarin. 65 a low testosterone level or sperm count, or both 226 Version 2016.3576– – Document LATEXed – 1st May 2016 [git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)
Oestrogens, conjugated Vaginal - cream - Premarin vaginal cream. Contraindications Oestrogen-dependent cancer, history of breast cancer, active thrombophlebitis, active or recent thromboembolic disease (e.g. angina or myocardial infarction), venous thromboembolism, or history of recurrent venous thromboembolism (unless already on anticoagulant treatment), liver disease (where liver function tests have failed to return to normal), breast feeding (BNF, 2016a). Adverse reactions Central Nervous System • headache, • dizziness, • chorea, • depression, • stroke, • seizures (Abramovitz, 2016). Cardiovascular • Thrombophlebitis, • thromboembolism, • hypertension, • oedema, • heart attack, • pulmonary embolism (Abramovitz, 2016). Eyes • Worsening myopia or astigmatism, • intolerance of contact lenses (Abramovitz, 2016). Gastrointestinal • nausea, • vomiting, • abdominal cramps, • bloating, • anorexia, • increased appetite, • pancreatitis, • increased risk of gallbladder disease (Abramovitz, 2016). Genitourinary 227 Version 2016.3576– – Document LATEXed – 1st May 2016 [git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)
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Sharon Kimble (S.E.N.,R.G.N.) Hormo
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Contents Leuprorelin Acetate . . .
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Contents Sperm banking . . . . . .
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List of Tables 13.10Reference range
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List of Figures 3.1 Positive and ne
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This document understandable format
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About the author About the author M
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Chapter 2 README FIRST This chapter
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Cyproterone Acetate • nocturia,
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Dydrogesterone Common side-effects
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Estradiol Valerate Cardiovascular
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Goserelin Common side-effects Gastr
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Oestrogel Also known as Regaine, Ro
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Testosterone • oedema, (Abramovit
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Triptorelin Common side-effects Gas
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Chapter 3 Preamble What are hormone
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Side effects want to keep your weig
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What changes will I see? 9 You can
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What changes will I see? Changes to
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What changes will I see? Female-to-
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What changes will I see? Changes to
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What changes will I see? Effect Bod
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Common therapies Oestrogens, conjug
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Drugs used in Female to Male transi
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How oestrogen works DNA’s genetic
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Hormone effects in male→female
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Hormone effects in female→male
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Hormone effects in female→male Ga
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Hormone effects in female→male De
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An overview of the endocrine system
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The major endocrine glands Table 4.
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The Biochemistry of Sex Hormones Fi
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The Biochemistry of Sex Hormones Fi
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Female Genital Anatomy • Epididym
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Female Genital Anatomy of the breas
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Chapter 6 Hormones Estradiol Valera
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Estradiol Valerate If you are signi
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Estradiol Valerate Deferasirox - Th
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Estradiol Valerate Siltuximab - The
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Estradiol Valerate • Nausea, •
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Estradiol Valerate Metabolism - Est
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Oestrogel • Significant increase
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Oestrogel Interactions Drug interac
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Oestrogel • breast swelling, •
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Sandrena • A history of endometri
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Sandrena Breastfeeding Sandrena is
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Sandrena Psychiatric disorders •
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Testosterone Testosterone Administr
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Testosterone being. Examples includ
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Testosterone • Amenorrhoea, • o
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Testosterone Disopyramide - Testost
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Testosterone Effects on Lab Test Re
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Testosterone Schedule IV - Drugs th
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Dutasteride Contains Dutasteride 50
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Dutasteride Pharmacodynamics The on
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Finasteride Effects on Lab Test Res
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Finasteride Pharmacodynamics Finast
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Finasteride Patient Teaching Tell p
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Bicalutamide Pharmacology Bicalutam
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Bicalutamide Hepatic Hepatic side e
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Bicalutamide Cisapride - The serum
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Cyproterone Acetate Administration
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Cyproterone Acetate How it works Th
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Cyproterone Acetate Estradiol - The
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Cyproterone Acetate Repaglinide - T
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Flutamide Note Should be taken afte
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Flutamide Interactions Drug-drug Wa
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Flutamide Contraindications Sensiti
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Goserelin Shelf life Drogenil = 60
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Goserelin Typical dosage Pre-op 3.6
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Goserelin • Sexual dysfunction,
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Goserelin Ciprofloxacin - Goserelin
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Goserelin Itraconazole - Itraconazo
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Goserelin Sorafenib - Sorafenib may
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Leuprorelin Acetate Self-care tips
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Leuprorelin Acetate which leads to
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Leuprorelin Acetate Anagrelide - Le
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Leuprorelin Acetate Flupentixol - L
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Leuprorelin Acetate Mifepristone -
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Leuprorelin Acetate Tacrolimus - Ta
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Triptorelin Triptorelin Alternative
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Triptorelin Insulin Regular - The t
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Triptorelin • anorexia, • gout,
Page 175 and 176: Triptorelin Distribution The volume
Page 177 and 178: Triptorelin The suspension vehicle
Page 179 and 180: Triptorelin • Triptorelin may rai
Page 181 and 182: Chapter 9 Progestogens Dydrogestero
Page 183 and 184: Dydrogesterone Pharmacodynamics Dyd
Page 185 and 186: Dydrogesterone Danaparoid - The the
Page 187 and 188: Progesterone Contains Cylcogest - P
Page 189 and 190: Progesterone • Fatigue, • heada
Page 191 and 192: Progesterone Bosentan - The serum c
Page 193 and 194: Progesterone Repaglinide - The ther
Page 195 and 196: Chapter 10 Other useful drugs This
Page 197 and 198: Emla Cream Slight erythema is frequ
Page 199 and 200: Emla Cream Typical dosage Electroly
Page 201 and 202: Minoxidil Warning Do not use near y
Page 203 and 204: Vaniqa Eflornithine is a prescripti
Page 205 and 206: Vaniqa Patients may need to continu
Page 207 and 208: Ethinylestradiol Contains Ethinyles
Page 209 and 210: Ethinylestradiol • Headache, •
Page 211 and 212: Ethinylestradiol Bortezomib - The m
Page 213 and 214: Ethinylestradiol Secobarbital - The
Page 215 and 216: Medroxyprogesterone Acetate Warning
Page 217 and 218: Medroxyprogesterone Acetate Route T
Page 219 and 220: Medroxyprogesterone Acetate Atazana
Page 221 and 222: Medroxyprogesterone Acetate Insulin
Page 223 and 224: Medroxyprogesterone Acetate Topiram
Page 225: Oestrogens, conjugated Action Mimic
Page 229 and 230: Oestrogens, conjugated Cyclosporine
Page 231 and 232: Spironolactone Spironolactone - liq
Page 233 and 234: Spironolactone Contraindications Hy
Page 235 and 236: Spironolactone Chlorphenamine - The
Page 237 and 238: Spironolactone Racepinephrine - Spi
Page 239 and 240: Spironolactone Warning You should b
Page 241 and 242: Breast Self Examination can be succ
Page 243 and 244: Deep Vein Thrombosis - You should a
Page 245 and 246: Deep Vein Thrombosis Epidemiology
Page 247 and 248: Osteoporosis Treating a DVT Treatme
Page 249 and 250: Osteoporosis Your sex - Women are m
Page 251 and 252: Prostate cancer Height loss and ost
Page 253 and 254: Testicular Self Examination Figure
Page 255 and 256: Testicular Self Examination Signs o
Page 257 and 258: Urinary Tract Infections - UTI’s
Page 259 and 260: Urinary Tract Infections - UTI’s
Page 261 and 262: Blood testing What To Expect After
Page 263 and 264: Blood testing Production of red blo
Page 265 and 266: Blood testing Proper handling of th
Page 267 and 268: Blood groups Antigens and antibodie
Page 269 and 270: Alkaline phosphate - ALP Male Femal
Page 271 and 272: Blood Glucose High bilirubin levels
Page 273 and 274: Cholesterol HDL (Good) Cholesterol
Page 275 and 276: Cholesterol • Stroke, • Serious
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Dehydroepiandrosterone sulphate - D
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Dihydrotestosterone - DHT elevation
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Follicle stimulating hormone - FSH
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High-density lipoprotein - HDL In m
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Low-density lipoprotein - LDL relat
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Liver function tests Indications Th
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Luteinizing hormone - LH Other test
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Oestrogen Test Conventional SI Unit
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Prolactin - PRL Low oestrogen level
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Sex hormone binding globulin - SHBG
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Testosterone Test Conventional SI U
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Thyroxine, free - T4 Raised testost
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Blood, urea and nitrogen - BUN •
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Full Blood Count - FBC Mean corpusc
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Full Blood Count - FBC Lymphocytes
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Full Blood Count - FBC More commonl
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Full Blood Count - FBC High platele
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International Normalised Ratio - IN
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Prostate specific antigen - PSA •
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Prostate specific antigen - PSA Dig
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Thyroid function test - TFT Once ag
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Urine and electrolytes • collect
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Urine and electrolytes Normal Value
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Urine and electrolytes What abnorma
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Urine and electrolytes • Low magn
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Albumin What abnormal results mean
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Chapter 15 Sexually transmitted inf
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Chlamydia It’s passed on from one
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Chlamydia the eyes - if they come i
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Genital herpes Genital herpes Genit
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Genital herpes ⋆ vaginal discharg
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Genital herpes • If urinating is
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Genital warts • Use condoms (male
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Genital warts How will I know if I
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Genital warts Because HPV is spread
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Gonorrhoea Signs and symptoms You m
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Gonorrhoea Sometimes you may be ask
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Hepatitis You can always go back to
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Hepatitis • rimming • fingering
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Hepatitis • as a result of blood-
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Hepatitis • have close contact wi
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Hepatitis • jaundice, • mental
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HIV Why should I get treated? Hepat
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HIV A woman with HIV can transmit t
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HIV • people who have caught anot
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HIV An HIV test should only be done
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HIV • PEP is an emergency measure
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HIV Treatment is usually recommende
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Molluscum contagiosum Molluscum con
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Molluscum contagiosum When to seek
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Molluscum contagiosum The treatment
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Molluscum contagiosum Pulsed-dye la
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Pubic lice What are the signs and s
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Scabies Finding empty eggshells (de
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Scabies Scabies mites can survive o
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Shigella What should I do if I thin
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Syphilis Statistics for 2014 showed
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Syphilis The latent stage can conti
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Syphilis You will be prescribed ano
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Trichomoniasis How is it passed on?
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How to avoid sexually transmitted i
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Condoms Avoid other types of contac
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Condoms • If you are having anal
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Condoms Some men and women are sens
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Condoms Are there different types o
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Condoms Disadvantages • Some coup
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Condoms If you buy condoms online,
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Condoms • Now put your index or m
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Condoms Risks There are no serious
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Condoms Don’t use lotion or oils
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Bacterial vaginosis - BV Women with
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Bacterial vaginosis - BV The level
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Bacterial vaginosis - BV Things to
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Proctitis Proctitis Proctitis is so
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Thrush Symptoms • Irritation, bur
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Thrush It is very important to take
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Thrush Avoid Men should also try to
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Urethritis Urethritis Urethritis is
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Urethritis Other infections A numbe
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Urethritis You will be asked not to
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Urethritis NGU and sexually transmi
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Urethritis • epididymitis is infl
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Vaginal Thrush What to do if you ha
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Vaginal Thrush Emollients and antif
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Vaginitis • Pain when you wee,
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Accessing your health records • A
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Accessing your health records An at
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Adrenal Fatigue Symptoms said to be
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Adrenal Insufficiency Adrenal Insuf
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Bio-equivalence Product Presentatio
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Bio-equivalence Generic Brand Form
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Blood levels Active ingredient Bran
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Blood levels Hormone Female Male Bl
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Blood tests • SHBG, • testoster
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Blood tests Analyte Specimen Conven
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Blood tests Analyte Folliclestimula
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Blood tests Analyte •Content leve
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Body fat Analyte Specimen Conventio
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Breast Development Figure 17.2 - Th
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Breast disorders • As time passes
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Breast disorders Symptom Causes Com
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Breast disorders The breast is palp
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Breast disorders CBE is usually par
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Breast disorders Red flags Certain
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Breast disorders Nipple discharge c
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Breast disorders Cause Suggestive f
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Breast disorders the area around th
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Breast disorders Diffuse bilateral
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Breast Implants Saline implant rupt
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Breast Screening What is the NHS Br
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Breast Screening • some cancers a
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Coming out A personal experience. W
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Consent and Informed Consent Consen
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Cycling Hormones? thanks to its ant
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E-numbers Drug names Medicines norm
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Expiry dates What to do? There are
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Further discussion of Vitamin D Fac
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Gender expression) related to that
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Getting a urine sample or otherwise
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Grapefruit Juice • avoid cocaine,
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Grapefruit Juice Generic Brand Clin
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Heamatological Reference Values Ana
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How to Take Your Tablets. This last
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Implants, Testosterone and Estradio
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Infection? Labial redness variable
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Injections Syringe size Your syring
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Injections 4 Using your "Ampoule Op
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Injections 10 Where appropriate a
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Injections Figure 17.9 - This shows
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Kegel exercises Kegel exercises Fig
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Lactation the muscle for a count of
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Liver damage All products absorbed
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Male pregnancy root), preventing th
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Measuring Your Transition • Measu
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Menopause suggest a specific influe
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Menopause Male menopause Male menop
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Menopause Men normally experience a
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Menopausal symptoms Menopausal symp
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Mood swings and depression See also
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Oestrogen and Alzheimer’s Disease
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Pelvic examination • manual, •
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Pharmacodynamics Pharmacodynamics T
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Premarin Premarin This drug is, sup
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Prescriptions Medical exemptions Pe
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Prostate cancer Prostate cancer The
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Regimes Hormone regimes for transge
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Regimes Name Dosage When taken OR 5
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Regimes Parenterally (i.m. or subcu
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Safety of HRT • Getting older,
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Sexual Health Dementia Evorel [estr
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Sexual Health Mammography Women sho
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Skin care Skin care One of the unfo
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Skin care Sensitive Skin Please not
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Skin care Sanitise your tools Wash
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Skin care • Lemon juice works wel
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Sleep more often reported a variety
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Sleep The stages of NREM sleep and
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Sleep Sleep fragmentation results f
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Smoking and taking hormones Many st
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Stopping hormones prior to surgery
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Stress management Stress management
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Stress management A single episode
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Stress management Reach out - Make
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Stress management Why you react to
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Stress management Reframe your thou
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Stress management • Stressing abo
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Stress management Try aromatherapy
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Stress management your mind as well
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Stretch marks Maintain healthy rela
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Supplies Supplies In the UK Nu-Care
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Testosterone replacement therapy, m
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The real side effects of testostero
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The real side effects of testostero
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The risks of breast cancer One stud
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Thrush "The FDA has reviewed the av
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Transgender Definitions 1 It can’
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Transgender Definitions Cross Dress
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Transgender Definitions Dyke This i
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Transphobia Transwoman A male-to-fe
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Transphobia When referring to trans
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Treatment aims • online abuse,
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Urinary Tract Infections 1 IU 45.5
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Vitality Children Vaginitis usually
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Vitamins Age Folate µg Niacin mg R
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Vitamins Deficiencies - Inadequate
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Vitamins Recommended Dietary Allowa
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Vitamins Food Sources - Avocado, ba
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What is a ’vitamin’? that contr
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Zoff Review the material again - Re
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Books Made In God’s Image: A Reso
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Email This site is strictly for MTF
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Some web sites Some web sites All l
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Chapter 19 Appendix 1 American vs B
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How to evaluate health information
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Glossary A | B | C | D | E | F | G
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Glossary cancerous malignant . . .
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Glossary G gastric lavage stomach w
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Glossary lipophilic the ability to
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Glossary spermatogenesis Spermatoge
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Acronyms A | B | C | D | E | F | G
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Acronyms HRT Hormone Replacement Th
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Bibliography [AB, 2011] CellaVision
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Bibliography [Beastall, Ferguson, O
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Bibliography [Burger, 2002] H. G. B
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Bibliography [Corona, Maseroli, Ras
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Bibliography [drugbank, 2014b] 2014
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Bibliography [Fogelman, 1991] L Fog
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Bibliography [Gossman, 2014] MV Gos
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Bibliography [helpguide, 2016b] 201
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Bibliography [L. Johnson, 2014] LE
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Bibliography [Kuper, Mantzoros, Lag
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Bibliography [Lippert, A. O. Mueck,
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Bibliography [mayoclinic, 2014c] 20
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Bibliography [MIMS, 2016a] MIMS 201
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Bibliography [NHS, 2014f] 2014f HIV
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Bibliography [O’Sullivan, 2013] M
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Bibliography [Rasgon, Geist, Kenna,
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Bibliography [Sabon, Cheng, Stommel
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Bibliography [takingcharge, 2010] t
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Bibliography [ucsfhealth, 2009b] 20
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Bibliography [unknown, 2015e] 2015e
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[wikipedia, 2016] 2016 Tanner scale
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Medroxyprogesterone Acetate 215 Oes
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interaction Carbamezapine . . . . .
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depressed mood . . . . . . . . . .
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liver failure . . . . . . . . . . .
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transient erythema . . . . . . . .
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pancreatitis . . . . . . . . . . .
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Vaniqa acne . . . . . . . . . . . .
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Aminophylline Cyproterone Acetate .
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Capromab Bicalutamide . . . . . . .
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Nelfinavir . . . . . . . . . . . .
Page 745 and 746:
Edetic Acid Cyproterone Acetate . .
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C1 Esterase Inhibitor (Human) 213 C
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Leuprorelin Acetate . . . . . . . 1
Page 751 and 752:
Propofol . . . . . . . . . . . . .
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Progesterone. . . . . . . . . . . .
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Maprotiline . . . . . . . . . . . .
Page 757 and 758:
Glimepiride . . . . . . . . . . . .
Page 759 and 760:
Bicalutamide . . . . . . . . . . .
Page 761 and 762:
Goserelin . . . . . . . . . . . . .
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Saxagliptin Cyproterone Acetate . .
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Tasimelteon Cyproterone Acetate . .
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Goserelin . . . . . . . . . . . . .
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Index of STI’s A Avoidance . . .
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Curettage . . . . . . . . . . . . .
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General Index A Accessing someone e
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What happens? . . . . . . . . . . .
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Importing hormones. . . . . . . . .
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S Safety of our regimes . . . . . .
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