Hormones 2016

Bicalutamide
Respiratory
Dyspnoea. Uncommon cases of interstitial lung disease, including
interstitial pneumonitis and pulmonary fibrosis have been reported with
the use of bicalutamide. One case of pneumonitis has also been reported
(Abramovitz, 2016)
Dermatological
• sweating (Abramovitz, 2016)
• unusual bleeding or bruising
(medlineplus, 2015b)
Other
In one phase II clinical trial with bicalutamide used as a single agent -
• breast tenderness - 63.4%,
• breast swelling - 52.5%, and
• hot flashes - 23.6% were reported
respectively (unknown,
2014a),
Another phase II clinical trial with bicalutamide used as a single agent
reported -
• breast pain - 76%, and
• gynaecomastia - 60% of treated
patients, respectively. This
study also showed
• generalized pain - 30% of
treated patients,
• hot flashes - 28%,
• pelvic pain - 26%, and
• libido decrease - 25% and
• impotence - 25% (unknown,
2014a).
Interactions
Although the usage of warfarin is not contra-indicated, you should be
monitored closely.
Acenocoumarol - The serum concentration of Acenocoumarol can be ↑
when it is combined with Bicalutamide.
Aripiprazole - The serum concentration of Aripiprazole can be ↑ when it is
combined with Bicalutamide.
Astemizole - The serum concentration of Astemizole can be ↑ when it is
combined with Bicalutamide.
Capromab - Bicalutamide may ↓ effectiveness of Capromab as a diagnostic
agent.
Choline C 11 - The therapeutic efficacy of Choline C 11 can be ↓ when used
in combination with Bicalutamide.
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Version 2016.3576– – Document LATEXed – 1st May 2016
[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)