Hormones 2016

Grapefruit Juice
• avoid cocaine, crack cocaine, crystal meth, ecstasy, ketamine and GHB,
Bone disorders
Your bones are living and growing. The strength of your bones, or bone
density, is determined by the amount of calcium, phosphorous and other
minerals they contain.
Age is also a risk factor for bone problems, as is gender. Women, for instance,
have a higher risk than men of osteoporosis, a bone disease that causes
bones to become thin and fragile and to break easily, particularly at the hip,
spine and wrist. This is partly because women have 30% less bone mass
than men. But women are also particularly vulnerable to osteoporosis after
menopause, when the hormone oestrogen — a key factor in maintaining
bone strength in women — is no longer produced by the ovaries.
Also see Osteoporosis.
Prescriptions
I’m hearing anecdotal reports about folk in the USA who are being refused
transdermal patches by their insurance provider because after the age of 64,
you are ’at risk’ when using them!
Grapefruit Juice
Grapefruit or grapefruit juice has been shown to affect the metabolism
of many medications, increasing the risk of toxicity and adverse events.
Characteristics of oral medications that may interact with grapefruit
include extensive metabolism through the intestinal cytochrome P450 3A4
(CYP3A4) system, low bioavailability, and a narrow therapeutic index.
Grapefruit juice interacts through the intestinal CYP3A4 system and can
inhibit the concentration for 24–72hrs. This is not an exclusive list of
medications that may interact with grapefruit. Caution should be taken
by both patient and doctor and monitor adverse reactions when taking
medications that may interact with grapefruit or its juice.
Generic Brand Clinical Implications of Co-administration
with Grapefruit or Grapefruit Juice
alkaloid 114
114 any of a group of organic basic substances found in plants, many of which are
pharmacologically active, e.g., atropine, caffeine, morphine, nicotine, quinine, and
strychnine
515
Version 2016.3576– – Document LATEXed – 1st May 2016
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