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Hormones 2016

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Male pattern baldness<br />

available), or by intramuscular injection. All of those methods allow the<br />

hormone to enter the bloodstream first which means there is better efficiency<br />

and only waste product hormones will go through the liver in much smaller<br />

amounts.<br />

I have had great difficulty in determining exactly how damaging elevated<br />

estradiol levels may be to one’s liver. A recent study published in<br />

"Oncology: International Journal of Cancer Research and Treatment", in a<br />

hospital-based case-controlled study of male liver cancer patients in Greece<br />

which looked specifically at the phenomena of elevated estradiol levels in<br />

such patients. It looked at 98 cancer patients and 111 control cases. It had<br />

been claimed that the elevated estradiol levels may have been responsible<br />

for the liver damage, however that claim was not supported by this study.<br />

When the researchers compensated for the fact that the cancer patients’<br />

livers were compromised, and therefore incapable of dealing with steroid<br />

hormones efficiently, the conclusion was that the elevated estradiol levels<br />

were a consequence of the liver damage, not the cause of it (Kuper et al.,<br />

2001).<br />

Part of the difficulty in determining what the actual liver damage risk is<br />

posed by estradiol is that there are too many variables to simply say you<br />

have X% chance of harming your liver if you take oral estradiol. If your<br />

liver is already compromised by pre-existing liver disease, or you have<br />

a predisposition to liver-related complications, or if you mega-dose (as<br />

mentioned above) thus consuming "toxic" levels, you’re obviously going<br />

to have a far greater risk than someone without such factors (hemingways,<br />

2004c).<br />

See the section on Progesterone below for liver toxicity information<br />

regarding that hormone.<br />

Male pattern baldness<br />

Male pattern baldness, or androgenic alopecia, typically affects the front and<br />

top of the scalp first where the most genetically-susceptible hair follicles<br />

reside. DHT is the primary contributing factor in male pattern baldness.<br />

Female hair loss can be very complicated and DHT could be just one of the<br />

possible causes. In women DHT is influenced by a decrease in oestrogen<br />

and hair loss tends to result in thinning, rather than complete balding.<br />

DHT inhibits and reduces the proper growth of hair in the follicles in<br />

a process called ’miniaturisation’. "Miniaturisation" affects geneticallysusceptible<br />

hair follicles resulting in lighter, finer hairs. DHT attaches itself<br />

to receptor cells of the part of these follicles called dermal papillas (the<br />

540<br />

Version <strong>2016</strong>.3576– – Document LATEXed – 1st May <strong>2016</strong><br />

[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (<strong>2016</strong>-05-01)

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