Hormones 2016

Oestrogens, conjugated
• Vaginal candidiasis,
• testicular atrophy,
• impotence (Abramovitz, 2016).
Hepatic
• Cholestatic jaundice,
• hepatic adenoma 66 (Abramovitz,
2016).
Metabolic
• Hypercalcemia,
• weight changes,
• hypertriglyceridemia 67 (Abramovitz,
2016).
Skin
• melasma 68 ,
• rash,
• hirsutism or hair loss,
• erythema nodosum 69 ,
• erythema multiforme,
• dermatitis (Abramovitz, 2016).
Other
• breast tenderness,
• breast enlargement,
• gynaecomastia,
• increased risk of breast cancer
(Abramovitz, 2016).
Interactions
Carbamazepine, fosphenytoin, phenobarbital, phenytoin, rifampin -
May ↓ effectiveness of oestrogen therapy. Monitor patient closely.
Clarithromycin, erythromycin, itraconazole, ketoconazole, ritonavir -
May ↑ oestrogen plasma levels and side effects. Monitor patient.
Corticosteroids - May ↑ corticosteroid effects. Monitor patient closely.
66 a benign tumour of the liver, usually occurring in women in association with lengthy
oral contraceptive use
67 elevated triglyceride concentration in the blood
68 a tan or dark skin discolouration
69 An inflammation of subcutaneous tissue marked by the sudden formation of painful
nodes on the extensor surfaces of the lower extremities, with lesions that are self limiting
but tend to recur(unknown, 2013d)
228
Version 2016.3576– – Document LATEXed – 1st May 2016
[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)