Hormones 2016

Emla Cream
Slight erythema is frequently seen at the site of application and is due to the
pharmacological action of amethocaine in dilating capillary vessels. This
may help in delineating the anaesthetised area.
Slight oedema or itching are less frequently seen at the site of application.
This may be due to the local release of histamine and 5-HT.
More severe erythema, oedema and/or itching confined to the site of
application have rarely been reported (skyscape, 2014).
Usage
Apply the contents of the tube to the centre of the area to be anaesthetised
and cover with an occlusive dressing (cling film can also be used). After the
appropriate time the gel should be removed prior to treatment (skyscape,
2014).
The contents expellable from 1 tube (approximately 1 gram) are sufficient
to cover and anaesthetise an area of up to 30 square centimetres (skyscape,
2014).
Do not apply to broken skin. Not to be taken internally (skyscape, 2014).
Interactions
Hyaluronidase - The risk or severity of adverse effects can be increased
when Hyaluronidase is combined with Tetracaine.
Technetium Tc-99m tilmanocept - Tetracaine may decrease effectiveness
of Technetium Tc-99m tilmanocept as a diagnostic agent (drugbank,
2015e).
Warning
Repeated exposure to Ametop gel may increase the risk of sensitisation
reactions to Amethocaine (skyscape, 2014).
Ametop gel, like other local anaesthetics may be ototoxic and should not
be instilled into the middle ear or used for procedures which might involve
penetration into the middle ear (skyscape, 2014).
Emla Cream
EMLA stands for ’eutectic mixture of local anaesthetic’.
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Version 2016.3576– – Document LATEXed – 1st May 2016
[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)