Hormones 2016

Bio-equivalence
Active ingredient Brand Source of oestrogen
Synthetic Enjuvia Plant derived:
conjugated
Soy/Yams
oestrogen
Esterified oestrogens
Menest Plant derived:
Soy/Yams
17-β-estradiol Estrace Plant derived:
(micronized)
Soy/Yams
17-β-estradiol Femtrace Plant derived:
Soy/Yams
Transdermal
17-β-estradiol Estraderm Plant derived:
(reservoir) 90
patch
Soy/Yams
17-β-estradiol
Plant derived:
patch (matrix) 91 mara or Viv-
Soy/Yams
elle or Vivelle-
Dot or Menostar
17-β-estradiol gel Divigel Plant derived:
Soy/Yams,
Sunflower seeds,
Rapeseed, Poppy
seeds, Pine trees
17-β-estradiol gel Elestrin Plant derived:
Soy, Rapeseed,
Pine tree wood
17-β-estradiol gel Estrogel Plant derived: Oil
seed, Soy, Pine
tree wood
Dose equivalents
0.625mg
0.625mg
1mg
No equivalence
data, only studied
with placebo
0.05mg
0.05mg
1g Divigel
= 34pg/mL
estradiol
1 pump (0.87g/d)
= 0.0125mg
estradiol, 2
pumps (1.7g/d)
= 0.0375mg
estradiol
No comparison
studies done
in U.S., Rate
of delivery is
35µg/day which
is therapeutically
equivalent
to Climara
50µg/day
90 Estradiol is contained in a drug reservoir and its release is controlled by a copolymer
membrane, it contains more layers than a matrix patch
91 Estradiol is embedded in the adhesive layer that is applied directly to the skin
458
Version 2016.3576– – Document LATEXed – 1st May 2016
[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)