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Estradiol Valerate<br />

Siltuximab - The serum concentration of Estradiol can be ↓ when it is<br />

combined with Siltuximab.<br />

Somatropin recombinant - The therapeutic efficacy of Somatropin recombinant<br />

can be ↓ when used in combination with Estradiol.<br />

St. John’s Wort - The serum concentration of Estradiol can be ↓ when it is<br />

combined with St. John’s Wort.<br />

Sulodexide - Estradiol may ↓ the anticoagulant activities of Sulodexide.<br />

Teriflunomide - The serum concentration of Estradiol can be ↓ when it is<br />

combined with Teriflunomide.<br />

Tesmilifene - The serum concentration of Estradiol can be ↓ when it is<br />

combined with Tesmilifene.<br />

Thalidomide - Estradiol may ↑ the thrombogenic activities of Thalidomide.<br />

Theophylline - The serum concentration of Theophylline can be ↑ when it<br />

is combined with Estradiol.<br />

Tipranavir - Estradiol may ↑ the dermatologic adverse activities of<br />

Tipranavir.<br />

Tizanidine - The serum concentration of Tizanidine can be ↑ when it is<br />

combined with Estradiol.<br />

Tocilizumab - The serum concentration of Estradiol can be ↓ when it is<br />

combined with Tocilizumab.<br />

Tolbutamide - The therapeutic efficacy of Tolbutamide can be ↓ when used<br />

in combination with Estradiol.<br />

Treprostinil - Estradiol may ↓ the anticoagulant activities of Treprostinil.<br />

Triamterene - Estradiol may ↑ the hyperkalemic activities of Triamterene.<br />

Ursodeoxycholic acid - The therapeutic efficacy of Ursodeoxycholic acid<br />

can be ↓ when used in combination with Estradiol.<br />

Valsartan - Valsartan may ↑ the hyperkalemic activities of Estradiol.<br />

Verapamil - The serum concentration of Estradiol can be ↑ when it is<br />

combined with Verapamil.<br />

Vildagliptin - The therapeutic efficacy of Vildagliptin can be ↓ when used<br />

in combination with Estradiol.<br />

Vitamin C - The serum concentration of Estradiol can be ↑ when it is<br />

combined with Vitamin C.<br />

Warfarin - Estradiol may ↓ the anticoagulant activities of Warfarin<br />

(drugbank, 2015c).<br />

Drug-herb<br />

• Blue cohosh - May ↑ drug’s adverse effects. Discourage use together.<br />

• Saw palmetto - May negate drug’s effects. Discourage use together.<br />

• St. John’s wort - May ↓ effects of drug. Discourage use together<br />

(Abramovitz, <strong>2016</strong>).<br />

Drug-food<br />

• Caffeine - May ↑ caffeine level. Advise patient to avoid or minimize<br />

use of caffeine.<br />

Version <strong>2016</strong>.3576– – Document LATEXed – 1st May <strong>2016</strong><br />

85<br />

[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (<strong>2016</strong>-05-01)

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