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Hormones 2016

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Oestrogens, conjugated<br />

Cyclosporine - May ↑ risk of toxicity. Use together with caution, and<br />

monitor cyclosporine level frequently.<br />

Dantrolene, hepatotoxic drugs - May ↑ risk of hepatotoxicity. Monitor<br />

liver function closely.<br />

Oral anticoagulants - May ↓ anticoagulant effects. Adjust dosage if needed.<br />

Monitor PT and INR.<br />

Tamoxifen - May interfere with tamoxifen effectiveness. Avoid using<br />

together (Abramovitz, <strong>2016</strong>).<br />

Drug-herb<br />

St. John’s wort - May ↓ effects of drug.<br />

(Abramovitz, <strong>2016</strong>).<br />

Discourage use together<br />

Drug-food<br />

Caffeine - May ↑ caffeine level. Urge caution.<br />

Grapefruit, grapefruit juice - May ↑ risk of adverse effects. Discourage use<br />

together (Abramovitz, <strong>2016</strong>).<br />

Drug-lifestyle<br />

Smoking - May ↑ risk of cardiovascular effects. If smoking continues, may<br />

need another form of therapy (Abramovitz, <strong>2016</strong>).<br />

Effects on Lab Test Results<br />

May ↑ calcium, thyroid-binding globulin, serum triglyceride, serum<br />

phospholipid, and clotting factor VII, VIII, IX, and X levels.<br />

May ↑ norepinephrine-induced platelet aggregation and PT.<br />

May ↓ metyrapone test results and cause impaired glucose tolerance<br />

(Abramovitz, <strong>2016</strong>).<br />

Shelf Life<br />

Both drugs have a shelf life of 36 months (emc, <strong>2016</strong>).<br />

Notes<br />

Take oral dose with food or milk to decrease/minimise gastrointestinal<br />

symptoms (Abramovitz, <strong>2016</strong>).<br />

229<br />

Version <strong>2016</strong>.3576– – Document LATEXed – 1st May <strong>2016</strong><br />

[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (<strong>2016</strong>-05-01)

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