Hormones 2016

Grapefruit Juice
Antihelminthic 116
praziquantel Biltricide
Generic Brand Clinical Implications of Co-administration
with Grapefruit or Grapefruit Juice
colchicine Colcrys Increases the risk of colchicine-induced toxic
effects, significant increase in colchicine
plasma concentration is anticipated. Grapefruit
and grapefruit juice should not be
consumed during colchicine treatment.
Antiarrhythmics 115
amiodarone Cordarone Inhibits CYP3A4-mediated metabolism
of oral amiodarone resulting in increase
plasma levels of amiodarone. Avoid coadministration.
dofetilide Tikosyn Inhibitor of the CYP3A4 isoenzyme, thus
could increase systemic dofetilide exposure.
If co-administration is necessary, use with
caution.
dronedarone Multaq Moderate inhibitor of CYP3A, results in a 3-
fold increase in dronedarone exposure and
a 2.5-fold increase in Cmax. Avoid coadministration.
1.6-fold increase in the Cmax and a 1.9-fold
increase in the AUC of praziquantel.
antipsychotic 117
pimozide Orap Inhibits CYP3A4-mediated metabolism of
pimozide. Avoid co-administration.
Calcium channel blockers 118
felodipine Plendil 2-fold increase in felodipine AUC and Cmax.
Avoid co-administration prior to and during
treatment.
nifedipine Procardia 2-fold increase in nifedipine AUC and Cmax
with no change in half-life. Avoid coadministration.
nisoldipine Sular 3-fold increase in nisoldipine Cmax and 2-
fold increase in nisoldipine AUC. Avoid coadministration
before and after dosing.
115 used to control cardiac arrhythmia, including membrane-stabilizing drugs (e.g.
quinidine, lidocaine, flecainide), beta-blockers, amiodarone and sotalol and calcium
channel blockers (e.g. verapamil)
116 used to destroy or cause the expulsion of parasitic intestinal worms
117 effective in the treatment of psychotic disorders; also, an agent that so acts.
Antipsychotics are a chemically diverse but pharmacologically similar class of drugs;
besides psychotic disorders, some are also used to treat movement disorders, intractable
hiccups, or severe nausea and vomiting
118 medication that slows the movement of calcium into the cells of the heart and blood
vessels. This, in turn, relaxes blood vessels, increases the supply of oxygen-rich blood to
the heart, and reduces the heart’s workload
516
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