Hormones 2016

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Drugs used in Male to Female transitioning Micronized Progesterone (e.g.Prometrium) A pill you take daily Thought to be lower risk Not as widely available (Transhealth, 2015a) Name Safety Efficacy Source Progesterone excellent highly variable Yams or Soy Beans Dydrogesterone good variable synthetic Medroxyprogesterone Acetate Deprecated fair variable synthetic Table 3.19 – Popular progesteronic drugs GnRH Agonists Name Goserelin Leuprorelin Acetate Safety & Efficacy excellent fair Table 3.20 – Popular GnRH agonists Drugs used in Male to Female transitioning • Cyproterone Acetate - Androcur, Cyprostat. • Dydrogesterone - Duphaston, Duphaston HRT. • Estradiol Valerate - Climaval, Estraderm MX, Estradiol implant, Progynova, Progynova TS, Progynova TS forte, Zumenon. • Finasteride - Proscar. • Flutamide - Drogenil. • Goserelin - Zoladex, Zoladex LA. • Leuprorelin Acetate - Prostap SR, Prostap 3. • Minoxidil - Regaine. • Oestrogel - Oestrogel. • Progesterone - Cyclogest, Gestone. These are listed in alphabetical order. Some are hormones, some are antiandrogens, some are DHT-blockers, and some are progesterones, and so they are dealt with in separate chapters. Version 2016.3576– – Document LATEXed – 1st May 2016 46 [git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)
Drugs used in Female to Male transitioning Drugs used in Female to Male transitioning Testosterone - Sustanon 100, Sustanon 250. How oestrogen works Oestrogen drug products act by regulating the transcription 8 of a limited number of genes. Oestrogens diffuse through cell membranes, distribute themselves throughout the cell, and bind to and activate the nuclear oestrogen receptor, a deoxyribonucleic acid (DNA)-binding protein which is found in oestrogen-receptive tissues. The activated oestrogen receptor binds to specific DNA sequences, or hormone response elements, which enhances the transcription of adjacent genes and in turn lead to the observed effects. Oestrogen receptors have been identified in tissues of the reproductive tract, breast, pituitary, hypothalamus, liver, and bone of women (unknown, 2004a). Oestrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. With other hormones, such as pituitary hormones and progesterone, they cause enlargement of the breasts, through promotion of ductal growth, stromal development, and the accretion of fat. Oestrogens occur naturally in several forms. The primary source of oestrogen in normally cycling adult women is the ovarian follicle, which secretes 70–500 micrograms of estradiol daily, dependant on the phase of the menstrual cycle. This is converted primarily to estrone, which circulates in roughly equal proportion to estradiol, and to small amounts of estriol. After the menopause, most endogenous oestrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. Thus, estrone - especially in it’s sulphate ester form - is the most abundant circulating oestrogen on postmenopausal women. Although circulating oestrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principle intercellular human oestrogen and is substantially more potent than estrone or estriol at the receptor. Oestrogens used in therapy are well absorbed through the skin, mucous membranes, and gastrointestinal tract. When applied for a local action, absorption is usually sufficient to cause systemic effects. When conjugated with aryl and alkyl groups for parenteral administration, the rate of absorption of oily preparations is slowed with a prolonged duration of action, such that a singular injection of estradiol valerate or estradiol cypionate is absorbed over several weeks. Administered oestrogens and their esters are handled within the body essentially the same as the endogenous hormones. Metabolic conversion of oestrogens occurs primarily in the liver (first pass effect), but also at local target 8 The natural process by which a molecule of RNA is synthsized on the model of a DNA template carrying the necessary genetic information Version 2016.3576– – Document LATEXed – 1st May 2016 47 [git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)
Page 1 and 2: Sharon Kimble (S.E.N.,R.G.N.) Hormo
Page 3 and 4: Contents Leuprorelin Acetate . . .
Page 5 and 6: Contents Sperm banking . . . . . .
Page 7 and 8: List of Tables 13.10Reference range
Page 9 and 10: List of Figures 3.1 Positive and ne
Page 11 and 12: This document understandable format
Page 13 and 14: About the author About the author M
Page 15 and 16: Chapter 2 README FIRST This chapter
Page 17 and 18: Cyproterone Acetate • nocturia,
Page 19 and 20: Dydrogesterone Common side-effects
Page 21 and 22: Estradiol Valerate Cardiovascular
Page 23 and 24: Goserelin Common side-effects Gastr
Page 25 and 26: Oestrogel Also known as Regaine, Ro
Page 27 and 28: Testosterone • oedema, (Abramovit
Page 29 and 30: Triptorelin Common side-effects Gas
Page 31 and 32: Chapter 3 Preamble What are hormone
Page 33 and 34: Side effects want to keep your weig
Page 35 and 36: What changes will I see? 9 You can
Page 37 and 38: What changes will I see? Changes to
Page 39 and 40: What changes will I see? Female-to-
Page 41 and 42: What changes will I see? Changes to
Page 43 and 44: What changes will I see? Effect Bod
Page 45: Common therapies Oestrogens, conjug
Page 49 and 50: How oestrogen works DNA’s genetic
Page 51 and 52: Hormone effects in male→female
Page 57 and 58: Hormone effects in female→male
Page 63 and 64: Hormone effects in female→male Ga
Page 65 and 66: Hormone effects in female→male De
Page 67 and 68: An overview of the endocrine system
Page 69 and 70: The major endocrine glands Table 4.
Page 71 and 72: The Biochemistry of Sex Hormones Fi
Page 73 and 74: The Biochemistry of Sex Hormones Fi
Page 75 and 76: Female Genital Anatomy • Epididym
Page 77 and 78: Female Genital Anatomy of the breas
Page 79 and 80: Chapter 6 Hormones Estradiol Valera
Page 81 and 82: Estradiol Valerate If you are signi
Page 83 and 84: Estradiol Valerate Deferasirox - Th
Page 85 and 86: Estradiol Valerate Siltuximab - The
Page 87 and 88: Estradiol Valerate • Nausea, •
Page 89 and 90: Estradiol Valerate Metabolism - Est
Page 91 and 92: Oestrogel • Significant increase
Page 93 and 94: Oestrogel Interactions Drug interac
Page 95 and 96: Oestrogel • breast swelling, •
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Sandrena • A history of endometri
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Sandrena Breastfeeding Sandrena is
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Sandrena Psychiatric disorders •
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Testosterone Testosterone Administr
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Testosterone being. Examples includ
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Testosterone • Amenorrhoea, • o
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Testosterone Disopyramide - Testost
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Testosterone Effects on Lab Test Re
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Testosterone Schedule IV - Drugs th
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Dutasteride Contains Dutasteride 50
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Dutasteride Pharmacodynamics The on
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Finasteride Effects on Lab Test Res
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Finasteride Pharmacodynamics Finast
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Finasteride Patient Teaching Tell p
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Bicalutamide Pharmacology Bicalutam
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Bicalutamide Hepatic Hepatic side e
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Bicalutamide Cisapride - The serum
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Cyproterone Acetate Administration
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Cyproterone Acetate How it works Th
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Cyproterone Acetate Estradiol - The
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Cyproterone Acetate Repaglinide - T
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Flutamide Note Should be taken afte
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Flutamide Interactions Drug-drug Wa
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Flutamide Contraindications Sensiti
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Goserelin Shelf life Drogenil = 60
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Goserelin Typical dosage Pre-op 3.6
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Goserelin • Sexual dysfunction,
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Goserelin Ciprofloxacin - Goserelin
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Goserelin Itraconazole - Itraconazo
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Goserelin Sorafenib - Sorafenib may
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Leuprorelin Acetate Self-care tips
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Leuprorelin Acetate which leads to
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Leuprorelin Acetate Anagrelide - Le
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Leuprorelin Acetate Flupentixol - L
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Leuprorelin Acetate Mifepristone -
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Leuprorelin Acetate Tacrolimus - Ta
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Triptorelin Triptorelin Alternative
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Triptorelin Insulin Regular - The t
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Triptorelin • anorexia, • gout,
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Triptorelin Distribution The volume
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Triptorelin The suspension vehicle
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Triptorelin • Triptorelin may rai
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Chapter 9 Progestogens Dydrogestero
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Dydrogesterone Pharmacodynamics Dyd
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Dydrogesterone Danaparoid - The the
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Progesterone Contains Cylcogest - P
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Progesterone • Fatigue, • heada
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Progesterone Bosentan - The serum c
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Progesterone Repaglinide - The ther
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Chapter 10 Other useful drugs This
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Emla Cream Slight erythema is frequ
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Emla Cream Typical dosage Electroly
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Minoxidil Warning Do not use near y
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Vaniqa Eflornithine is a prescripti
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Vaniqa Patients may need to continu
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Ethinylestradiol Contains Ethinyles
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Ethinylestradiol • Headache, •
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Ethinylestradiol Bortezomib - The m
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Ethinylestradiol Secobarbital - The
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Medroxyprogesterone Acetate Warning
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Medroxyprogesterone Acetate Route T
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Medroxyprogesterone Acetate Atazana
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Medroxyprogesterone Acetate Insulin
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Medroxyprogesterone Acetate Topiram
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Oestrogens, conjugated Action Mimic
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Oestrogens, conjugated Vaginal - cr
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Oestrogens, conjugated Cyclosporine
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Spironolactone Spironolactone - liq
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Spironolactone Contraindications Hy
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Spironolactone Chlorphenamine - The
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Spironolactone Racepinephrine - Spi
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Spironolactone Warning You should b
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Breast Self Examination can be succ
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Deep Vein Thrombosis - You should a
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Deep Vein Thrombosis Epidemiology
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Osteoporosis Treating a DVT Treatme
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Osteoporosis Your sex - Women are m
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Prostate cancer Height loss and ost
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Testicular Self Examination Figure
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Testicular Self Examination Signs o
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Urinary Tract Infections - UTI’s
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Urinary Tract Infections - UTI’s
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Blood testing What To Expect After
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Blood testing Production of red blo
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Blood testing Proper handling of th
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Blood groups Antigens and antibodie
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Alkaline phosphate - ALP Male Femal
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Blood Glucose High bilirubin levels
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Cholesterol HDL (Good) Cholesterol
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Cholesterol • Stroke, • Serious
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Dehydroepiandrosterone sulphate - D
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Dihydrotestosterone - DHT elevation
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Follicle stimulating hormone - FSH
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High-density lipoprotein - HDL In m
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Low-density lipoprotein - LDL relat
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Liver function tests Indications Th
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Luteinizing hormone - LH Other test
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Oestrogen Test Conventional SI Unit
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Prolactin - PRL Low oestrogen level
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Sex hormone binding globulin - SHBG
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Testosterone Test Conventional SI U
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Thyroxine, free - T4 Raised testost
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Blood, urea and nitrogen - BUN •
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Full Blood Count - FBC Mean corpusc
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Full Blood Count - FBC Lymphocytes
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Full Blood Count - FBC More commonl
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Full Blood Count - FBC High platele
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International Normalised Ratio - IN
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Prostate specific antigen - PSA •
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Prostate specific antigen - PSA Dig
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Thyroid function test - TFT Once ag
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Urine and electrolytes • collect
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Urine and electrolytes Normal Value
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Urine and electrolytes What abnorma
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Urine and electrolytes • Low magn
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Albumin What abnormal results mean
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Chapter 15 Sexually transmitted inf
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Chlamydia It’s passed on from one
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Chlamydia the eyes - if they come i
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Genital herpes Genital herpes Genit
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Genital herpes ⋆ vaginal discharg
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Genital herpes • If urinating is
Page 341 and 342:
Genital warts • Use condoms (male
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Genital warts How will I know if I
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Genital warts Because HPV is spread
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Gonorrhoea Signs and symptoms You m
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Gonorrhoea Sometimes you may be ask
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Hepatitis You can always go back to
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Hepatitis • rimming • fingering
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Hepatitis • as a result of blood-
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Hepatitis • have close contact wi
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Hepatitis • jaundice, • mental
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HIV Why should I get treated? Hepat
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HIV A woman with HIV can transmit t
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HIV • people who have caught anot
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HIV An HIV test should only be done
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HIV • PEP is an emergency measure
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HIV Treatment is usually recommende
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Molluscum contagiosum Molluscum con
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Molluscum contagiosum When to seek
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Molluscum contagiosum The treatment
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Molluscum contagiosum Pulsed-dye la
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Pubic lice What are the signs and s
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Scabies Finding empty eggshells (de
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Scabies Scabies mites can survive o
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Shigella What should I do if I thin
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Syphilis Statistics for 2014 showed
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Syphilis The latent stage can conti
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Syphilis You will be prescribed ano
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Trichomoniasis How is it passed on?
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How to avoid sexually transmitted i
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Condoms Avoid other types of contac
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Condoms • If you are having anal
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Condoms Some men and women are sens
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Condoms Are there different types o
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Condoms Disadvantages • Some coup
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Condoms If you buy condoms online,
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Condoms • Now put your index or m
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Condoms Risks There are no serious
Page 415 and 416:
Condoms Don’t use lotion or oils
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Bacterial vaginosis - BV Women with
Page 419 and 420:
Bacterial vaginosis - BV The level
Page 421 and 422:
Bacterial vaginosis - BV Things to
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Proctitis Proctitis Proctitis is so
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Thrush Symptoms • Irritation, bur
Page 427 and 428:
Thrush It is very important to take
Page 429 and 430:
Thrush Avoid Men should also try to
Page 431 and 432:
Urethritis Urethritis Urethritis is
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Urethritis Other infections A numbe
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Urethritis You will be asked not to
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Urethritis NGU and sexually transmi
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Urethritis • epididymitis is infl
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Vaginal Thrush What to do if you ha
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Vaginal Thrush Emollients and antif
Page 445 and 446:
Vaginitis • Pain when you wee,
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Accessing your health records • A
Page 449 and 450:
Accessing your health records An at
Page 451 and 452:
Adrenal Fatigue Symptoms said to be
Page 453 and 454:
Adrenal Insufficiency Adrenal Insuf
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Bio-equivalence Product Presentatio
Page 457 and 458:
Bio-equivalence Generic Brand Form
Page 459 and 460:
Blood levels Active ingredient Bran
Page 461 and 462:
Blood levels Hormone Female Male Bl
Page 463 and 464:
Blood tests • SHBG, • testoster
Page 465 and 466:
Blood tests Analyte Specimen Conven
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Blood tests Analyte Folliclestimula
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Blood tests Analyte •Content leve
Page 471 and 472:
Body fat Analyte Specimen Conventio
Page 473 and 474:
Breast Development Figure 17.2 - Th
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Breast disorders • As time passes
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Breast disorders Symptom Causes Com
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Breast disorders The breast is palp
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Breast disorders CBE is usually par
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Breast disorders Red flags Certain
Page 485 and 486:
Breast disorders Nipple discharge c
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Breast disorders Cause Suggestive f
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Breast disorders the area around th
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Breast disorders Diffuse bilateral
Page 493 and 494:
Breast Implants Saline implant rupt
Page 495 and 496:
Breast Screening What is the NHS Br
Page 497 and 498:
Breast Screening • some cancers a
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Coming out A personal experience. W
Page 501 and 502:
Consent and Informed Consent Consen
Page 503 and 504:
Cycling Hormones? thanks to its ant
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E-numbers Drug names Medicines norm
Page 507 and 508:
Expiry dates What to do? There are
Page 509 and 510:
Further discussion of Vitamin D Fac
Page 511 and 512:
Gender expression) related to that
Page 513 and 514:
Getting a urine sample or otherwise
Page 515 and 516:
Grapefruit Juice • avoid cocaine,
Page 517 and 518:
Grapefruit Juice Generic Brand Clin
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Heamatological Reference Values Ana
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How to Take Your Tablets. This last
Page 523 and 524:
Implants, Testosterone and Estradio
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Infection? Labial redness variable
Page 527 and 528:
Injections Syringe size Your syring
Page 529 and 530:
Injections 4 Using your "Ampoule Op
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Injections 10 Where appropriate a
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Injections Figure 17.9 - This shows
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Kegel exercises Kegel exercises Fig
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Lactation the muscle for a count of
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Liver damage All products absorbed
Page 541 and 542:
Male pregnancy root), preventing th
Page 543 and 544:
Measuring Your Transition • Measu
Page 545 and 546:
Menopause suggest a specific influe
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Menopause Male menopause Male menop
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Menopause Men normally experience a
Page 551 and 552:
Menopausal symptoms Menopausal symp
Page 553 and 554:
Mood swings and depression See also
Page 555 and 556:
Oestrogen and Alzheimer’s Disease
Page 557 and 558:
Pelvic examination • manual, •
Page 559 and 560:
Pharmacodynamics Pharmacodynamics T
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Premarin Premarin This drug is, sup
Page 563 and 564:
Prescriptions Medical exemptions Pe
Page 565 and 566:
Prostate cancer Prostate cancer The
Page 567 and 568:
Regimes Hormone regimes for transge
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Regimes Name Dosage When taken OR 5
Page 571 and 572:
Regimes Parenterally (i.m. or subcu
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Safety of HRT • Getting older,
Page 575 and 576:
Sexual Health Dementia Evorel [estr
Page 577 and 578:
Sexual Health Mammography Women sho
Page 579 and 580:
Skin care Skin care One of the unfo
Page 581 and 582:
Skin care Sensitive Skin Please not
Page 583 and 584:
Skin care Sanitise your tools Wash
Page 585 and 586:
Skin care • Lemon juice works wel
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Sleep more often reported a variety
Page 589 and 590:
Sleep The stages of NREM sleep and
Page 591 and 592:
Sleep Sleep fragmentation results f
Page 593 and 594:
Smoking and taking hormones Many st
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Stopping hormones prior to surgery
Page 597 and 598:
Stress management Stress management
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Stress management A single episode
Page 601 and 602:
Stress management Reach out - Make
Page 603 and 604:
Stress management Why you react to
Page 605 and 606:
Stress management Reframe your thou
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Stress management • Stressing abo
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Stress management Try aromatherapy
Page 611 and 612:
Stress management your mind as well
Page 613 and 614:
Stretch marks Maintain healthy rela
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Supplies Supplies In the UK Nu-Care
Page 617 and 618:
Testosterone replacement therapy, m
Page 619 and 620:
The real side effects of testostero
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The real side effects of testostero
Page 623 and 624:
The risks of breast cancer One stud
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Thrush "The FDA has reviewed the av
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Transgender Definitions 1 It can’
Page 629 and 630:
Transgender Definitions Cross Dress
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Transgender Definitions Dyke This i
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Transphobia Transwoman A male-to-fe
Page 635 and 636:
Transphobia When referring to trans
Page 637 and 638:
Treatment aims • online abuse,
Page 639 and 640:
Urinary Tract Infections 1 IU 45.5
Page 641 and 642:
Vitality Children Vaginitis usually
Page 643 and 644:
Vitamins Age Folate µg Niacin mg R
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Vitamins Deficiencies - Inadequate
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Vitamins Recommended Dietary Allowa
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Vitamins Food Sources - Avocado, ba
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What is a ’vitamin’? that contr
Page 653 and 654:
Zoff Review the material again - Re
Page 655 and 656:
Books Made In God’s Image: A Reso
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Email This site is strictly for MTF
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Some web sites Some web sites All l
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Chapter 19 Appendix 1 American vs B
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How to evaluate health information
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Glossary A | B | C | D | E | F | G
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Glossary cancerous malignant . . .
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Glossary G gastric lavage stomach w
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Glossary lipophilic the ability to
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Glossary spermatogenesis Spermatoge
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Acronyms A | B | C | D | E | F | G
Page 681 and 682:
Acronyms HRT Hormone Replacement Th
Page 683 and 684:
Bibliography [AB, 2011] CellaVision
Page 685 and 686:
Bibliography [Beastall, Ferguson, O
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Bibliography [Burger, 2002] H. G. B
Page 689 and 690:
Bibliography [Corona, Maseroli, Ras
Page 691 and 692:
Bibliography [drugbank, 2014b] 2014
Page 693 and 694:
Bibliography [Fogelman, 1991] L Fog
Page 695 and 696:
Bibliography [Gossman, 2014] MV Gos
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Bibliography [helpguide, 2016b] 201
Page 699 and 700:
Bibliography [L. Johnson, 2014] LE
Page 701 and 702:
Bibliography [Kuper, Mantzoros, Lag
Page 703 and 704:
Bibliography [Lippert, A. O. Mueck,
Page 705 and 706:
Bibliography [mayoclinic, 2014c] 20
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Bibliography [MIMS, 2016a] MIMS 201
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Bibliography [NHS, 2014f] 2014f HIV
Page 711 and 712:
Bibliography [O’Sullivan, 2013] M
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Bibliography [Rasgon, Geist, Kenna,
Page 715 and 716:
Bibliography [Sabon, Cheng, Stommel
Page 717 and 718:
Bibliography [takingcharge, 2010] t
Page 719 and 720:
Bibliography [ucsfhealth, 2009b] 20
Page 721 and 722:
Bibliography [unknown, 2015e] 2015e
Page 723 and 724:
[wikipedia, 2016] 2016 Tanner scale
Page 725 and 726:
Medroxyprogesterone Acetate 215 Oes
Page 727 and 728:
interaction Carbamezapine . . . . .
Page 729 and 730:
depressed mood . . . . . . . . . .
Page 731 and 732:
liver failure . . . . . . . . . . .
Page 733 and 734:
transient erythema . . . . . . . .
Page 735 and 736:
pancreatitis . . . . . . . . . . .
Page 737 and 738:
Vaniqa acne . . . . . . . . . . . .
Page 739 and 740:
Aminophylline Cyproterone Acetate .
Page 741 and 742:
Capromab Bicalutamide . . . . . . .
Page 743 and 744:
Nelfinavir . . . . . . . . . . . .
Page 745 and 746:
Edetic Acid Cyproterone Acetate . .
Page 747 and 748:
C1 Esterase Inhibitor (Human) 213 C
Page 749 and 750:
Leuprorelin Acetate . . . . . . . 1
Page 751 and 752:
Propofol . . . . . . . . . . . . .
Page 753 and 754:
Progesterone. . . . . . . . . . . .
Page 755 and 756:
Maprotiline . . . . . . . . . . . .
Page 757 and 758:
Glimepiride . . . . . . . . . . . .
Page 759 and 760:
Bicalutamide . . . . . . . . . . .
Page 761 and 762:
Goserelin . . . . . . . . . . . . .
Page 763 and 764:
Saxagliptin Cyproterone Acetate . .
Page 765 and 766:
Tasimelteon Cyproterone Acetate . .
Page 767 and 768:
Goserelin . . . . . . . . . . . . .
Page 769 and 770:
Index of STI’s A Avoidance . . .
Page 771 and 772:
Curettage . . . . . . . . . . . . .
Page 773 and 774:
General Index A Accessing someone e
Page 775 and 776:
What happens? . . . . . . . . . . .
Page 777 and 778:
Importing hormones. . . . . . . . .
Page 779 and 780:
S Safety of our regimes . . . . . .
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