Hormones 2016

Triptorelin
After 60 days of subcutaneous treatment followed by a minimum of
four estrus cycles prior to mating, triptorelin, at doses of 2, 20, and 200
mcg/kg/day in saline (approximately 0.2, 2, and 16 times the estimated
human daily dose based on body surface area) or 2 monthly injections as
slow release microspheres ( 20 mcg/kg/day), had no effect on the fertility
or general reproductive function of female rats.
No studies were conducted to assess the effect of triptorelin on male fertility
(rxisk, 2014).
Warnings
Important safety information -
• Triptorelin may cause dizziness or vision changes. These effects
may be worse if you take it with alcohol or certain medicines. Use
triptorelin with caution. Do not drive or perform other possibly unsafe
tasks until you know how you react to it.
• Certain hormone levels may increase during the first few weeks
of treatment with triptorelin. This may cause you to experience
worsening symptoms or onset of new symptoms (eg, bone pain; blood
in the urine; difficulty urinating; burning, numbness, or tingling)
during the first few weeks of treatment.
• Triptorelin lowers the amount of certain hormones in your body. This
may cause certain expected side effects to occur, such as -
⋆ breast enlargement, soreness, or tenderness;
⋆ testicular changes, pain, or soreness;
⋆ decreased sexual ability;
⋆ hot flashes;
⋆ night sweats. Contact your doctor if you have questions or
concerns or if you experience any of these side effects.
• Lowering the amount of male hormones in the body may increase the
risk of a certain type of irregular heartbeat (prolonged QT interval).
Discuss any questions or concerns with your doctor.
• A slight increase in the risk of stroke or serious and sometimes fatal
heart problems has been reported with the use of GnRH agonists in
men. Although the risk appears to be low, seek immediate medical
attention if you experience -
⋆ chest, jaw, or left arm pain;
⋆ confusion;
⋆ fainting;
⋆ numbness of an arm or leg;
⋆ one-sided weakness;
⋆ slurred speech;
⋆ sudden, severe headache or vomiting; or
⋆ vision changes. Discuss any questions or concerns with your
doctor (drugbank, 2016).
178
Version 2016.3576– – Document LATEXed – 1st May 2016
[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)