Hormones 2016

Flutamide
• hepatic encephalopathy, • liver failure (Abramovitz,
2016).
Skin
• Rash,
• photosensitivity 51 (Abramovitz,
2016).
Other
• loss of libido, • gynaecomastia (Abramovitz,
2016).
Effects on Lab Test Results
• May ↑ BUN, creatinine, haemoglobin, and liver enzyme levels.
• May ↓ platelet and WBC counts.
• May alter pituitary-gonadal system tests during therapy and for 12
weeks after (Abramovitz, 2016).
Overdose
In animal studies with flutamide alone, signs of overdose included -
• hypoactivity,
• piloerection 52 ,
• slow respiration,
• ataxia and/or
• lacrimation,
(drug-
• anorexia,
• tranquilization,
• emesis and
• methemoglobinaemia,
bank, 2014c).
The single dose of flutamide ordinarily associated with symptoms of
overdose or considered to be life-threatening has not been established. One
patient survived after taking more than 5g as a single dose - no adverse
effects were observed.
Since flutamide is highly protein bound, dialysis may not be of any use as
treatment for overdose (emc, 2016).
51 an abnormal degree of sensitivity of the skin to sunlight
52 hair standing erect and on end
144
Version 2016.3576– – Document LATEXed – 1st May 2016
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