Hormones 2016

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Bio-equivalence Generic Brand Form Strength Dosing Frequency Esterified oestrogens Menest tablets 0.3mg, 0.625mg, 1.25mg, 2.5mg Estradiol Femtrace tablets 0.9mg, 1.8mg Estradiol Estrace tablets 0.5mg, 1mg, (micronized) Synthetic conjugated oestrogens 2mg Enjuvia tablets 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg Transdermal Oestrogen Estradiol Alora matrix patch Climara matrix patch 0.025mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.06mg/day, 0.075mg/day, 0.1mg/day Divigel topical gel 0.25mg/pkt, 0.5mg/pkt, 1mg/pkt [git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01) Twice weekly Once weekly Once daily Elestrin topical gel 0.87g/pump Once daily Estraderm reservoir patch 0.05mg/day, 0.1mg/day Twice weekly Estrasorb topical 1.74g/pouch 2 pouches emulsion once daily Estrogel topical gel 1.25g/pump 1 pump once daily Evamist topical 1.53mg/spray Initially spray 1 spray daily, may increase to 2 - 3 sprays if needed Menostar matrix patch 0.014mg/day Minivelle patch 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day Vivelle matrix patch 456 0.05mg/day, 0.1mg/day Version 2016.3576– – Document LATEXed – 1st May 2016 Once weekly Twice weekly
Bio-equivalence Generic Brand Form Strength Dosing Frequency Vivelle- Dot 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day Vaginal Oestrogen Conjugated oestrogen Premarin cream 0.625mg/g Daily Estradiol Estring ring 7.5mcg/24hrs Once every 90 days Femring ring 0.05mg/day, Once every 0.1mg/day 3 months Vagifem vaginal 10mcg Once daily tablets for 2 weeks, then twice weekly Oral Progestogen Medroxyprogesterone Provera tablets 2.5mg, 5mg, Once daily acetate 10mg Progesterone (micronized) Prometriumcapsules 100mg, 200mg, 300mg (unknown, 2015d) Table 17.3 – Hormone Replacement Therapies Oral Oestrogens •Plasma oestrogen peaks & troughs •First pass through GI tract & liver (requires higher dose) •Increased hepatic enzymes, inflammatory markers •Increased triglycerides •Increased blood pressure •Reduced IGF-1 •Decreased LDL cholesterol and increased HDL Transdermal Oestrogens •Serum E2 levels relatively constant •Does not pass through liver, therefore lower doses required •No change in inflammatory markers •No change or decrease in triglycerides •Decrease in blood pressure •No effect on GH/IGF-1 •Decreases LDL but no change in HDL Table 17.4 – Oral oestrogens vs transdermal oestrogens - 1 Active ingredient Brand Source of oestrogen Oral Equine Premarin Pregnant mares conjugated urine oestrogen 457 Dose equivalents 0.625mg Version 2016.3576– – Document LATEXed – 1st May 2016 [git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)
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Sharon Kimble (S.E.N.,R.G.N.) Hormo
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Contents Leuprorelin Acetate . . .
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Contents Sperm banking . . . . . .
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List of Tables 13.10Reference range
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List of Figures 3.1 Positive and ne
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This document understandable format
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About the author About the author M
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Chapter 2 README FIRST This chapter
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Cyproterone Acetate • nocturia,
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Dydrogesterone Common side-effects
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Estradiol Valerate Cardiovascular
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Goserelin Common side-effects Gastr
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Oestrogel Also known as Regaine, Ro
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Testosterone • oedema, (Abramovit
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Triptorelin Common side-effects Gas
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Chapter 3 Preamble What are hormone
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Side effects want to keep your weig
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What changes will I see? 9 You can
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What changes will I see? Changes to
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What changes will I see? Female-to-
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What changes will I see? Changes to
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What changes will I see? Effect Bod
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Common therapies Oestrogens, conjug
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Drugs used in Female to Male transi
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How oestrogen works DNA’s genetic
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Hormone effects in male→female
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Hormone effects in female→male
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Hormone effects in female→male Ga
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Hormone effects in female→male De
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An overview of the endocrine system
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The major endocrine glands Table 4.
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The Biochemistry of Sex Hormones Fi
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The Biochemistry of Sex Hormones Fi
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Female Genital Anatomy • Epididym
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Female Genital Anatomy of the breas
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Chapter 6 Hormones Estradiol Valera
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Estradiol Valerate If you are signi
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Estradiol Valerate Deferasirox - Th
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Estradiol Valerate Siltuximab - The
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Estradiol Valerate • Nausea, •
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Estradiol Valerate Metabolism - Est
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Oestrogel • Significant increase
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Oestrogel Interactions Drug interac
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Oestrogel • breast swelling, •
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Sandrena • A history of endometri
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Sandrena Breastfeeding Sandrena is
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Sandrena Psychiatric disorders •
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Testosterone Testosterone Administr
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Testosterone being. Examples includ
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Testosterone • Amenorrhoea, • o
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Testosterone Disopyramide - Testost
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Testosterone Effects on Lab Test Re
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Testosterone Schedule IV - Drugs th
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Dutasteride Contains Dutasteride 50
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Dutasteride Pharmacodynamics The on
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Finasteride Effects on Lab Test Res
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Finasteride Pharmacodynamics Finast
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Finasteride Patient Teaching Tell p
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Bicalutamide Pharmacology Bicalutam
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Bicalutamide Hepatic Hepatic side e
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Bicalutamide Cisapride - The serum
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Cyproterone Acetate Administration
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Cyproterone Acetate How it works Th
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Cyproterone Acetate Estradiol - The
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Cyproterone Acetate Repaglinide - T
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Flutamide Note Should be taken afte
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Flutamide Interactions Drug-drug Wa
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Flutamide Contraindications Sensiti
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Goserelin Shelf life Drogenil = 60
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Goserelin Typical dosage Pre-op 3.6
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Goserelin • Sexual dysfunction,
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Goserelin Ciprofloxacin - Goserelin
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Goserelin Itraconazole - Itraconazo
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Goserelin Sorafenib - Sorafenib may
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Leuprorelin Acetate Self-care tips
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Leuprorelin Acetate which leads to
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Leuprorelin Acetate Anagrelide - Le
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Leuprorelin Acetate Flupentixol - L
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Leuprorelin Acetate Mifepristone -
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Leuprorelin Acetate Tacrolimus - Ta
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Triptorelin Triptorelin Alternative
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Triptorelin Insulin Regular - The t
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Triptorelin • anorexia, • gout,
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Triptorelin Distribution The volume
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Triptorelin The suspension vehicle
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Triptorelin • Triptorelin may rai
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Chapter 9 Progestogens Dydrogestero
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Dydrogesterone Pharmacodynamics Dyd
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Dydrogesterone Danaparoid - The the
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Progesterone Contains Cylcogest - P
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Progesterone • Fatigue, • heada
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Progesterone Bosentan - The serum c
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Progesterone Repaglinide - The ther
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Chapter 10 Other useful drugs This
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Emla Cream Slight erythema is frequ
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Emla Cream Typical dosage Electroly
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Minoxidil Warning Do not use near y
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Vaniqa Eflornithine is a prescripti
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Vaniqa Patients may need to continu
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Ethinylestradiol Contains Ethinyles
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Ethinylestradiol • Headache, •
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Ethinylestradiol Bortezomib - The m
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Ethinylestradiol Secobarbital - The
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Medroxyprogesterone Acetate Warning
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Medroxyprogesterone Acetate Route T
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Medroxyprogesterone Acetate Atazana
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Medroxyprogesterone Acetate Insulin
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Medroxyprogesterone Acetate Topiram
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Oestrogens, conjugated Action Mimic
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Oestrogens, conjugated Vaginal - cr
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Oestrogens, conjugated Cyclosporine
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Spironolactone Spironolactone - liq
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Spironolactone Contraindications Hy
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Spironolactone Chlorphenamine - The
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Spironolactone Racepinephrine - Spi
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Spironolactone Warning You should b
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Breast Self Examination can be succ
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Deep Vein Thrombosis - You should a
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Deep Vein Thrombosis Epidemiology
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Osteoporosis Treating a DVT Treatme
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Osteoporosis Your sex - Women are m
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Prostate cancer Height loss and ost
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Testicular Self Examination Figure
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Testicular Self Examination Signs o
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Urinary Tract Infections - UTI’s
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Urinary Tract Infections - UTI’s
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Blood testing What To Expect After
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Blood testing Production of red blo
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Blood testing Proper handling of th
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Blood groups Antigens and antibodie
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Alkaline phosphate - ALP Male Femal
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Blood Glucose High bilirubin levels
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Cholesterol HDL (Good) Cholesterol
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Cholesterol • Stroke, • Serious
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Dehydroepiandrosterone sulphate - D
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Dihydrotestosterone - DHT elevation
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Follicle stimulating hormone - FSH
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High-density lipoprotein - HDL In m
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Low-density lipoprotein - LDL relat
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Liver function tests Indications Th
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Luteinizing hormone - LH Other test
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Oestrogen Test Conventional SI Unit
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Prolactin - PRL Low oestrogen level
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Sex hormone binding globulin - SHBG
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Testosterone Test Conventional SI U
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Thyroxine, free - T4 Raised testost
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Blood, urea and nitrogen - BUN •
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Full Blood Count - FBC Mean corpusc
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Full Blood Count - FBC Lymphocytes
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Full Blood Count - FBC More commonl
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Full Blood Count - FBC High platele
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International Normalised Ratio - IN
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Prostate specific antigen - PSA •
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Prostate specific antigen - PSA Dig
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Thyroid function test - TFT Once ag
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Urine and electrolytes • collect
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Urine and electrolytes Normal Value
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Urine and electrolytes What abnorma
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Urine and electrolytes • Low magn
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Albumin What abnormal results mean
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Chapter 15 Sexually transmitted inf
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Chlamydia It’s passed on from one
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Chlamydia the eyes - if they come i
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Genital herpes Genital herpes Genit
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Genital herpes ⋆ vaginal discharg
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Genital herpes • If urinating is
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Genital warts • Use condoms (male
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Genital warts How will I know if I
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Genital warts Because HPV is spread
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Gonorrhoea Signs and symptoms You m
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Gonorrhoea Sometimes you may be ask
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Hepatitis You can always go back to
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Hepatitis • rimming • fingering
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Hepatitis • as a result of blood-
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Hepatitis • have close contact wi
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Hepatitis • jaundice, • mental
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HIV Why should I get treated? Hepat
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HIV A woman with HIV can transmit t
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HIV • people who have caught anot
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HIV An HIV test should only be done
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HIV • PEP is an emergency measure
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HIV Treatment is usually recommende
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Molluscum contagiosum Molluscum con
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Molluscum contagiosum When to seek
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Molluscum contagiosum The treatment
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Molluscum contagiosum Pulsed-dye la
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Pubic lice What are the signs and s
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Scabies Finding empty eggshells (de
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Scabies Scabies mites can survive o
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Shigella What should I do if I thin
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Syphilis Statistics for 2014 showed
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Syphilis The latent stage can conti
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Syphilis You will be prescribed ano
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Trichomoniasis How is it passed on?
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How to avoid sexually transmitted i
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Condoms Avoid other types of contac
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Condoms • If you are having anal
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Condoms Some men and women are sens
Page 405 and 406: Condoms Are there different types o
Page 407 and 408: Condoms Disadvantages • Some coup
Page 409 and 410: Condoms If you buy condoms online,
Page 411 and 412: Condoms • Now put your index or m
Page 413 and 414: Condoms Risks There are no serious
Page 415 and 416: Condoms Don’t use lotion or oils
Page 417 and 418: Bacterial vaginosis - BV Women with
Page 419 and 420: Bacterial vaginosis - BV The level
Page 421 and 422: Bacterial vaginosis - BV Things to
Page 423 and 424: Proctitis Proctitis Proctitis is so
Page 425 and 426: Thrush Symptoms • Irritation, bur
Page 427 and 428: Thrush It is very important to take
Page 429 and 430: Thrush Avoid Men should also try to
Page 431 and 432: Urethritis Urethritis Urethritis is
Page 433 and 434: Urethritis Other infections A numbe
Page 435 and 436: Urethritis You will be asked not to
Page 437 and 438: Urethritis NGU and sexually transmi
Page 439 and 440: Urethritis • epididymitis is infl
Page 441 and 442: Vaginal Thrush What to do if you ha
Page 443 and 444: Vaginal Thrush Emollients and antif
Page 445 and 446: Vaginitis • Pain when you wee,
Page 447 and 448: Accessing your health records • A
Page 449 and 450: Accessing your health records An at
Page 451 and 452: Adrenal Fatigue Symptoms said to be
Page 453 and 454: Adrenal Insufficiency Adrenal Insuf
Page 455: Bio-equivalence Product Presentatio
Page 459 and 460: Blood levels Active ingredient Bran
Page 461 and 462: Blood levels Hormone Female Male Bl
Page 463 and 464: Blood tests • SHBG, • testoster
Page 465 and 466: Blood tests Analyte Specimen Conven
Page 467 and 468: Blood tests Analyte Folliclestimula
Page 469 and 470: Blood tests Analyte •Content leve
Page 471 and 472: Body fat Analyte Specimen Conventio
Page 473 and 474: Breast Development Figure 17.2 - Th
Page 475 and 476: Breast disorders • As time passes
Page 477 and 478: Breast disorders Symptom Causes Com
Page 479 and 480: Breast disorders The breast is palp
Page 481 and 482: Breast disorders CBE is usually par
Page 483 and 484: Breast disorders Red flags Certain
Page 485 and 486: Breast disorders Nipple discharge c
Page 487 and 488: Breast disorders Cause Suggestive f
Page 489 and 490: Breast disorders the area around th
Page 491 and 492: Breast disorders Diffuse bilateral
Page 493 and 494: Breast Implants Saline implant rupt
Page 495 and 496: Breast Screening What is the NHS Br
Page 497 and 498: Breast Screening • some cancers a
Page 499 and 500: Coming out A personal experience. W
Page 501 and 502: Consent and Informed Consent Consen
Page 503 and 504: Cycling Hormones? thanks to its ant
Page 505 and 506: E-numbers Drug names Medicines norm
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Expiry dates What to do? There are
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Further discussion of Vitamin D Fac
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Gender expression) related to that
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Getting a urine sample or otherwise
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Grapefruit Juice • avoid cocaine,
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Grapefruit Juice Generic Brand Clin
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Heamatological Reference Values Ana
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How to Take Your Tablets. This last
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Implants, Testosterone and Estradio
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Infection? Labial redness variable
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Injections Syringe size Your syring
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Injections 4 Using your "Ampoule Op
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Injections 10 Where appropriate a
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Injections Figure 17.9 - This shows
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Kegel exercises Kegel exercises Fig
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Lactation the muscle for a count of
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Liver damage All products absorbed
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Male pregnancy root), preventing th
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Measuring Your Transition • Measu
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Menopause suggest a specific influe
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Menopause Male menopause Male menop
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Menopause Men normally experience a
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Menopausal symptoms Menopausal symp
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Mood swings and depression See also
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Oestrogen and Alzheimer’s Disease
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Pelvic examination • manual, •
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Pharmacodynamics Pharmacodynamics T
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Premarin Premarin This drug is, sup
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Prescriptions Medical exemptions Pe
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Prostate cancer Prostate cancer The
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Regimes Hormone regimes for transge
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Regimes Name Dosage When taken OR 5
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Regimes Parenterally (i.m. or subcu
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Safety of HRT • Getting older,
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Sexual Health Dementia Evorel [estr
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Sexual Health Mammography Women sho
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Skin care Skin care One of the unfo
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Skin care Sensitive Skin Please not
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Skin care Sanitise your tools Wash
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Skin care • Lemon juice works wel
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Sleep more often reported a variety
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Sleep The stages of NREM sleep and
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Sleep Sleep fragmentation results f
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Smoking and taking hormones Many st
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Stopping hormones prior to surgery
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Stress management Stress management
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Stress management A single episode
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Stress management Reach out - Make
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Stress management Why you react to
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Stress management Reframe your thou
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Stress management • Stressing abo
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Stress management Try aromatherapy
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Stress management your mind as well
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Stretch marks Maintain healthy rela
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Supplies Supplies In the UK Nu-Care
Page 617 and 618:
Testosterone replacement therapy, m
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The real side effects of testostero
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The real side effects of testostero
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The risks of breast cancer One stud
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Thrush "The FDA has reviewed the av
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Transgender Definitions 1 It can’
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Transgender Definitions Cross Dress
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Transgender Definitions Dyke This i
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Transphobia Transwoman A male-to-fe
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Transphobia When referring to trans
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Treatment aims • online abuse,
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Urinary Tract Infections 1 IU 45.5
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Vitality Children Vaginitis usually
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Vitamins Age Folate µg Niacin mg R
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Vitamins Deficiencies - Inadequate
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Vitamins Recommended Dietary Allowa
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Vitamins Food Sources - Avocado, ba
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What is a ’vitamin’? that contr
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Zoff Review the material again - Re
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Books Made In God’s Image: A Reso
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Email This site is strictly for MTF
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Some web sites Some web sites All l
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Chapter 19 Appendix 1 American vs B
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How to evaluate health information
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Glossary A | B | C | D | E | F | G
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Glossary cancerous malignant . . .
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Glossary G gastric lavage stomach w
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Glossary lipophilic the ability to
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Glossary spermatogenesis Spermatoge
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Acronyms A | B | C | D | E | F | G
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Acronyms HRT Hormone Replacement Th
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Bibliography [AB, 2011] CellaVision
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Bibliography [Beastall, Ferguson, O
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Bibliography [Burger, 2002] H. G. B
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Bibliography [Corona, Maseroli, Ras
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Bibliography [drugbank, 2014b] 2014
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Bibliography [Fogelman, 1991] L Fog
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Bibliography [Gossman, 2014] MV Gos
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Bibliography [helpguide, 2016b] 201
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Bibliography [L. Johnson, 2014] LE
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Bibliography [Kuper, Mantzoros, Lag
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Bibliography [Lippert, A. O. Mueck,
Page 705 and 706:
Bibliography [mayoclinic, 2014c] 20
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Bibliography [MIMS, 2016a] MIMS 201
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Bibliography [NHS, 2014f] 2014f HIV
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Bibliography [O’Sullivan, 2013] M
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Bibliography [Rasgon, Geist, Kenna,
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Bibliography [Sabon, Cheng, Stommel
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Bibliography [takingcharge, 2010] t
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Bibliography [ucsfhealth, 2009b] 20
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Bibliography [unknown, 2015e] 2015e
Page 723 and 724:
[wikipedia, 2016] 2016 Tanner scale
Page 725 and 726:
Medroxyprogesterone Acetate 215 Oes
Page 727 and 728:
interaction Carbamezapine . . . . .
Page 729 and 730:
depressed mood . . . . . . . . . .
Page 731 and 732:
liver failure . . . . . . . . . . .
Page 733 and 734:
transient erythema . . . . . . . .
Page 735 and 736:
pancreatitis . . . . . . . . . . .
Page 737 and 738:
Vaniqa acne . . . . . . . . . . . .
Page 739 and 740:
Aminophylline Cyproterone Acetate .
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Capromab Bicalutamide . . . . . . .
Page 743 and 744:
Nelfinavir . . . . . . . . . . . .
Page 745 and 746:
Edetic Acid Cyproterone Acetate . .
Page 747 and 748:
C1 Esterase Inhibitor (Human) 213 C
Page 749 and 750:
Leuprorelin Acetate . . . . . . . 1
Page 751 and 752:
Propofol . . . . . . . . . . . . .
Page 753 and 754:
Progesterone. . . . . . . . . . . .
Page 755 and 756:
Maprotiline . . . . . . . . . . . .
Page 757 and 758:
Glimepiride . . . . . . . . . . . .
Page 759 and 760:
Bicalutamide . . . . . . . . . . .
Page 761 and 762:
Goserelin . . . . . . . . . . . . .
Page 763 and 764:
Saxagliptin Cyproterone Acetate . .
Page 765 and 766:
Tasimelteon Cyproterone Acetate . .
Page 767 and 768:
Goserelin . . . . . . . . . . . . .
Page 769 and 770:
Index of STI’s A Avoidance . . .
Page 771 and 772:
Curettage . . . . . . . . . . . . .
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General Index A Accessing someone e
Page 775 and 776:
What happens? . . . . . . . . . . .
Page 777 and 778:
Importing hormones. . . . . . . . .
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S Safety of our regimes . . . . . .
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