Hormones 2016

Leuprorelin Acetate
which leads to a transient increase in gonadal steroid levels in both
men and women. Continued administration of leuprorelin acetate results
in a decrease of gonadotrophin and sex steroid levels. In men serum
testosterone levels, initially raised in response to early luteinising hormone
(LH) release, fall to castrate levels in about 2–4 weeks (emc, 2016).
Used in the palliative treatment of advanced prostate cancer. Leuprolide
is a luteinizing hormone agonist that results in suppression of testicular or
follicular steroidogenesis (drugbank, 2013f).
How it works
Leuprolide binds to the gonadotropin releasing hormone receptor and acts
as a potent inhibitor of gonadotropin secretion (drugbank, 2013f).
Typical dosage
Pre-op - 3.75–7.5mg/month.
Post-op - Should not be needed.
Route
Subcutaneous or intramuscular injection Prostap SR, Prostap 3
Contraindications
Hypersensitivity to GnRH or analogues, thromboembolic disorders
(drugs.com, 2014c).
Side-effects
Central Nervous system
• Headache, • rarely migraine (Macmillan,
2014).
Cardiovascular
• Heart disease (Macmillan, 2014).
Gastrointestinal
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Version 2016.3576– – Document LATEXed – 1st May 2016
[git] • Branch: 1.5 @ 26b5e6d • Release: 1.5 (2016-05-01)