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92<br />

ABDOMINAL ULTRASOUND<br />

E<br />

F<br />

G<br />

H<br />

Figure 4.16 cont’d (E) Large necrotic metastasis. (F) Miliary metastases affecting the entire liver. Some larger, focal<br />

lesions are also visible. Note the hepatic enlargement and the lobulated outline of the liver. (G) Following<br />

administration of microbubble contrast agent, numerous metastases are discovered. These appear hypoechoic in the<br />

late portal venous phase, with no contrast uptake. (H) Calcified metastases from breast carcinoma.<br />

possible primary carcinoma and to identify other<br />

sites of carcinomatous spread. Lymphadenopathy<br />

(particularly in the para-aortic, paracaval and portal<br />

regions) may be demonstrated on ultrasound,<br />

as well as invasion of adjacent blood vessels and<br />

disease in other extrahepatic sites including spleen,<br />

kidneys, omentum and peritoneum.<br />

Doppler is unhelpful in diagnosing liver metastases,<br />

most of which appear poorly vascular or avascular.<br />

With the larger deposits, small vessels may be<br />

identified most often at the periphery of the mass.<br />

The use of microbubble contrast agents has<br />

been shown to improve both the characterization<br />

and detection of metastatic deposits on ultrasound.<br />

8 The injection of a bolus of contrast agent<br />

when viewed using pulse-inversion demonstrates<br />

variable vascular phase enhancement with no contrast<br />

uptake in the late phase (Fig. 4.16G).<br />

Clinical features and management of liver<br />

metastases<br />

Many patients present with symptoms from their<br />

liver deposits rather than the primary carcinoma.<br />

The demonstration of liver metastases on ultrasound<br />

may often prompt further radiological inves-

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