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A<br />

C<br />

DISTANCE = 3.43 CM<br />

5%. 13 Over 70% of patients die from hepatic metastases<br />

within 3 years postoperatively. 14<br />

Differential diagnoses of pancreatic masses must<br />

always be considered (Table 5.2); focal lesions in<br />

the pancreas may represent inflammatory rather<br />

than malignant masses. An ultrasound-guided<br />

biopsy is sometimes useful in establishing the presence<br />

of adenocarcinoma if the biopsy is positive,<br />

but the sensitivity of this procedure is relatively<br />

low. 15 The value of a negative biopsy is dubious<br />

because of the inflammatory element surrounding<br />

many carcinomas.<br />

2<br />

4<br />

6<br />

8<br />

10<br />

12<br />

THE PANCREAS 129<br />

B<br />

D<br />

Endosonography-guided biopsy, however, has<br />

high sensitivity and specificity for diagnosing pancreatic<br />

cancer, and is also useful in patients with a<br />

previous negative biopsy in whom malignancy is<br />

suspected. 16 ERCP may also be used to insert a<br />

palliative stent in the common bile duct, to relieve<br />

biliary obstruction.<br />

The detection of a pancreatic carcinoma by<br />

ultrasound is usually followed by a CT scan for<br />

staging purposes as this will demonstrate invasion<br />

of peripancreatic fat, vascular involvement and<br />

lymphadenopathy. 16<br />

Figure 5.4 (A) Chronic pancreatitis in a patient with alcoholic cirrhosis; the pancreas is hyperechoic compared with<br />

the liver and has a heterogeneous texture with a lobulated outline. (B) Calcification of the pancreas in hereditary<br />

pancreatitis. (C) A cycle of acute on chronic pancreatitis, with pseudocysts and considerable calcification. (D) A stone<br />

(arrow) is obstructing the main pancreatic duct.

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