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INTERVENTIONAL AND OTHER TECHNIQUES 271<br />

main uses is in staging pancreatic tumours, predicting<br />

their resectability, identifying small lymph<br />

node metastases and assessing vascular invasion. 37<br />

It is particularly accurate in identifying small pancreatic<br />

insulinomas, 38 often difficult or impossible<br />

to identify on conventional cross-sectional imaging<br />

despite a documented biochemical abnormality,<br />

and thus guiding subsequent surgical procedures.<br />

Endoscopic ultrasound is also used in the detection<br />

of biliary calculi, particularly in the normal-calibre<br />

common bile duct, with a much higher accuracy<br />

than other imaging techniques and without the<br />

potential additional risks of ERCP. 39<br />

Further, less-established uses of endoscopic<br />

ultrasound include gastrointestinal examinations,<br />

in which invasion of gastric lesions into and<br />

through the wall of the stomach can be assessed, 40<br />

anal ultrasound, which is used to visualize the<br />

sphincter muscles in cases of sphincter dysfunction,<br />

the staging of colorectal carcinomas and the<br />

demonstration of bowel wall changes in inflammatory<br />

bowel conditions. 41<br />

The miniprobe has a higher frequency (20–30<br />

MHz) and may be passed down a conventional<br />

endoscope. It therefore has the advantage of a onestage<br />

gastrointestinal tract endoscopy/ERCP,<br />

rather than requiring a separate procedure. It may<br />

be inserted into the common duct of the biliary<br />

tree to assess local tumour invasion and to clarify<br />

the extent and/or nature of small lesions already<br />

identified by other imaging methods. It shows<br />

remarkable accuracy in the detection of common<br />

bile duct tumours and other biliary tract disease<br />

when compared with other imaging modalities. 42<br />

It may be used in the staging of oesophageal and<br />

gastric cancer, and is especially useful when a tight<br />

oesophageal stricture prevents the passage of the<br />

endoscope. 41 The layers of the oesophageal or gastric<br />

wall and the extent of tumour invasion can be<br />

accurately assessed.<br />

The miniprobe is also used in patients with suspected<br />

pancreatic carcinoma, for example in patients<br />

with a negative CT but who have irregularity of the<br />

pancreatic duct on contrast examination. The probe<br />

can be passed into the pancreatic duct during ERCP<br />

to detect small lesions, assess the extent of the<br />

tumour and predict resectability. 43 It is superior to<br />

conventional endoscopic ultrasound in the detection<br />

of the smaller, branch tumour nodules, and can<br />

also detect local retroperitoneal or vascular invasion<br />

in areas adjacent to the probe.<br />

The use of endoscopic ultrasound is currently<br />

limited to a few specialist centres. A steep learning<br />

curve together with the expense of the equipment<br />

is likely to restrict its widespread use; however, as<br />

its applications expand and its value becomes<br />

proven, it is likely to become a more routine investigation<br />

at many centres. 41<br />

References<br />

1. Ishii C, Yamada T, Irie T et al. 1996 Clinical<br />

evaluation of renal biopsy using automated biopsy<br />

gun under ultrasonography. Journal of Clinical<br />

Radiology 41: 233–236.<br />

2. Reading CC, Charboneau JW, James EM, Hunt MR.<br />

1988 Sonographically guided percutaneous biopsy of<br />

small (3 cm or less) masses. American Journal of<br />

Roentgenology 151(1): 189–92.<br />

3. Wilczek HE. 1990 Percutaneous needle biopsy of the<br />

renal allograft. Transplant 50: 790–797.<br />

4. Fornari F, Civardi G, Cavanna L et al. 1989<br />

Complications of ultrasonically guided fine needle<br />

abdominal biopsy: results of a multicenter Italian<br />

study and review of the literature. Scandinavian<br />

Journal of Gastroenterology 24: 949–955.<br />

5. Martino CR, Haaga JR, Bryan PJ et al. 1984 CT<br />

guided liver biopsies: eight years’ experience. Work in<br />

progress. Radiology 152(3): 755–757.<br />

6. Nolsoe C, Nielsen L, Torp-Pedersen S et al. 1990<br />

Major complications and deaths due to interventional<br />

ultrasonography: a review of 8000 cases. Journal of<br />

Clinical Ultrasound 18: 179–184.<br />

7. Smith EH. 1991 Complications of percutaneous<br />

abdominal fine needle biopsy. Radiology 178: 253–258.<br />

8. Di Stasi M, Buscarini L, Bolondi L et al. 1995<br />

Ultrasound-guided fine-needle liver biopsy: a multicentre<br />

survey of pre-procedure evaluation practices<br />

and complication rates. Journal of Interventional<br />

Radiology 10: 43–48.<br />

9. Livraghi T, Lazzaroni S, Civelli L et al. 1997 Risk<br />

conditions and mortality rate of abdominal fine needle<br />

biopsy. Journal of Interventional Radiology 12: 57–64.<br />

10. Ryd W, Hagmar B, Eriksson O. 1983 Local tumour<br />

cell seeding by fine needle aspiration biopsy. Acta<br />

Pathologica Microbiologica Immunologica<br />

Scandinavica 91: 17–21.

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