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INTERVENTIONAL AND OTHER TECHNIQUES 271<br />
main uses is in staging pancreatic tumours, predicting<br />
their resectability, identifying small lymph<br />
node metastases and assessing vascular invasion. 37<br />
It is particularly accurate in identifying small pancreatic<br />
insulinomas, 38 often difficult or impossible<br />
to identify on conventional cross-sectional imaging<br />
despite a documented biochemical abnormality,<br />
and thus guiding subsequent surgical procedures.<br />
Endoscopic ultrasound is also used in the detection<br />
of biliary calculi, particularly in the normal-calibre<br />
common bile duct, with a much higher accuracy<br />
than other imaging techniques and without the<br />
potential additional risks of ERCP. 39<br />
Further, less-established uses of endoscopic<br />
ultrasound include gastrointestinal examinations,<br />
in which invasion of gastric lesions into and<br />
through the wall of the stomach can be assessed, 40<br />
anal ultrasound, which is used to visualize the<br />
sphincter muscles in cases of sphincter dysfunction,<br />
the staging of colorectal carcinomas and the<br />
demonstration of bowel wall changes in inflammatory<br />
bowel conditions. 41<br />
The miniprobe has a higher frequency (20–30<br />
MHz) and may be passed down a conventional<br />
endoscope. It therefore has the advantage of a onestage<br />
gastrointestinal tract endoscopy/ERCP,<br />
rather than requiring a separate procedure. It may<br />
be inserted into the common duct of the biliary<br />
tree to assess local tumour invasion and to clarify<br />
the extent and/or nature of small lesions already<br />
identified by other imaging methods. It shows<br />
remarkable accuracy in the detection of common<br />
bile duct tumours and other biliary tract disease<br />
when compared with other imaging modalities. 42<br />
It may be used in the staging of oesophageal and<br />
gastric cancer, and is especially useful when a tight<br />
oesophageal stricture prevents the passage of the<br />
endoscope. 41 The layers of the oesophageal or gastric<br />
wall and the extent of tumour invasion can be<br />
accurately assessed.<br />
The miniprobe is also used in patients with suspected<br />
pancreatic carcinoma, for example in patients<br />
with a negative CT but who have irregularity of the<br />
pancreatic duct on contrast examination. The probe<br />
can be passed into the pancreatic duct during ERCP<br />
to detect small lesions, assess the extent of the<br />
tumour and predict resectability. 43 It is superior to<br />
conventional endoscopic ultrasound in the detection<br />
of the smaller, branch tumour nodules, and can<br />
also detect local retroperitoneal or vascular invasion<br />
in areas adjacent to the probe.<br />
The use of endoscopic ultrasound is currently<br />
limited to a few specialist centres. A steep learning<br />
curve together with the expense of the equipment<br />
is likely to restrict its widespread use; however, as<br />
its applications expand and its value becomes<br />
proven, it is likely to become a more routine investigation<br />
at many centres. 41<br />
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