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INTERVENTIONAL AND OTHER TECHNIQUES 261<br />
A full scan of the kidney is first performed to<br />
highlight potential problems, for example perirenal<br />
fluid collections, and to establish the safest<br />
and most effective route. The transplanted kidney<br />
lies in an extraperitoneal position and the<br />
chosen route should avoid puncturing the peritoneum,<br />
to minimize the risk of infection. Unlike<br />
the native kidney, the upper pole of the transplanted<br />
kidney is usually chosen to avoid major<br />
blood vessels and the ureter, which pass close to<br />
the lower pole.<br />
The biopsy aims to harvest glomeruli, and the<br />
chosen route should therefore target the renal cortex.<br />
An angle is chosen to include the maximum<br />
thickness of cortex and, where possible, avoid the<br />
renal hilum (Fig. 11.10).<br />
Upper<br />
pole<br />
A<br />
Proposed route<br />
Lower<br />
pole<br />
Complications of ultrasound-guided biopsy<br />
Postprocedure complications such as haematoma<br />
requiring blood transfusion and trauma to adjacent<br />
viscera occur very infrequently when ultrasound<br />
guidance is used. As expected, the risk of complications<br />
is less in fine-needle biopsy than with larger<br />
needles; 4 however, there is no significant difference<br />
in complication rate between a standard 18G Tru-<br />
Cut needle and a 22G Chiba needle. 5 The mortality<br />
and major complication rates vary but using a<br />
standard 18G needle these are approximately<br />
0.018–0.038% and 0.18–0.187% respectively, mortality<br />
being due to haemorrhage in 70%. As a working<br />
figure this means the mortality is approximately<br />
1 in 3300–5400 and morbidity 1 in 530 biopsies<br />
(Table 11.1). 4,6,7 The risk of haemorrhage is<br />
increased in patients with coexistent cirrhosis and is<br />
more likely to occur with malignant than benign<br />
lesions, 8,9 although large haemangiomas also can<br />
carry a significant risk of bleeding.<br />
As with any procedure of this nature, there is a<br />
very small risk of infection, which can be minimized<br />
by using an aseptic technique.<br />
Tumour seeding of the biopsy tract is an uncommon<br />
complication of biopsy and reports of tumour<br />
seeding are associated with repeated passes into the<br />
mass using large needles. Although much talked<br />
about, tumour track seeding is in fact rare, occurring<br />
in approximately 1 in 20 000 biopsies. 7,10 The bestknown<br />
tumours for this are mesothelioma and<br />
hepatoma.<br />
B<br />
Figure 11.10 (A) The transplanted kidney lies in the<br />
iliac fossa and is biopsied with the patient supine. (B)<br />
The needle is seen entering a transplanted kidney<br />
(arrowheads).<br />
Complications following abdominal biopsy are<br />
increased with multiple passes and are at least in<br />
part related to the skill and experience of the<br />
operator.<br />
If the biopsy result is negative or unexpected<br />
then a number of scenarios should be considered<br />
and include sampling error, poor histological specimen,<br />
sonographic or pathological misinterpretation<br />
or indeed a true negative finding. A repeat<br />
biopsy is sometimes justified.<br />
ULTRASOUND-GUIDED DRAINAGE<br />
Many fluid collections are the result of surgical<br />
intervention and often cannot be differentiated<br />
on ultrasound alone. Diagnostic aspiration of