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Animal Research
XII. Summary and Conclusions
I ) The ligature of the cystic duct and cystic artery were not susceptible
to producing acute cholecystitis in rabbits.
2) The ligature of the cystic duct associated to the galbladder introduction
of lysophosphatidilcoline unchained serious lesions of acute
cholecystitis in 91.6% of the rabbits - C2 and in 82.3% of the pigs
respectively.
3) The simultaneous administration of Diclofenac in the P2 group of pigs
- did not cause, in relation to group PI, a decrease of acute vesicular
lesions (82.3% P1 and 82.6% P2 respectively) (p=0.649).
4) It was possible to demonstrate bacteriobilia in 57.1% of group PI and
68.7% of group P2, associated with serious lesions of acute
cholecystitis.
5) The simultaneous administration of Diclofecnac in group P2 animals
did not have any influence in the bacteriobilia in relation to group
PI (57.1% PI and 68.7% P2 respectively) (p=0.781).
6) Our investigations permit us to conclude the inefficacy of non-steroid
antiinflammatories in the regression of acute cholecystitis lesions and
associated bacteriobilia.
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