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6 Biologicals Cytokines, growth factors and chemokines from PAN-Biotech Cytokines are becoming increasingly important in cell biology. Sugar-containing proteins have regulating functions for the growth and differentiation of body cells. Many cytokines also play an important role in immunological reactions, and they are then generally referred to as mediators. Cytokines, which primarily trigger resp. regulate the proliferation and differentiation of target cells are known as growth factors. These proteins that are transferred as signals from one cell to another, and therefore relay information, play a role mainly in the development of multicellular organisms. Growth factors are either secreted i.e. released by the cells into the environment or they are membrane-bound. They function when recognised by a receptor on the surface of the target cell. Only cells that carry the specific receptor for the respective growth factor (= ligand) can respond to the signal. When bound to its ligand through a change in conformation, this receptor generates a signal inside the cell, and this signal causes genes to be activated or deactivated by other signal transfers. PAN-Biotech can offer you a high-quality range of cytokines, growth factors as well as chemokines, chemotactical cytokines („chemoattractant cytokines“), which can be secreted from many cell types e.g. from phagocytes and dendritic cells but also from tissue cells. Chemokines can attract and activate leukocytes. They therefore play an important role as mediators in regulating targeted leukocyte migration and the inflammation processes triggered as a result. 6.1 Biologika Introduction/Einführung Cytokine, Wachstumsfaktoren und Chemokine von PAN-Biotech In der Zellbiologie nimmt die Bedeutung der Cytokine ständig zu. Die zuckerhaltigen Proteine besitzen regulierende Funktionen für das Wachstum und die Differenzierung von Körperzellen. Viele Cytokine spielen außerdem eine wichtige Rolle für immunologische Reaktionen, die dann allgemein als Mediatoren bezeichnet werden. Cytokine, die vor allem die Proliferation und Differenzierung von Zielzellen einleiten bzw. regulieren, werden als Wachstumsfaktoren bezeichnet. Diese Proteine, die als Signale von einer Zelle auf eine zweite übertragen werden und damit Informationen weiterleiten, spielen insbesondere eine Rolle bei der Entwicklung von mehrzelligen Organismen. Wachstumsfaktoren werden entweder sezerniert, also von Zellen in die Umgebung abgegeben, oder sie sind membranständig. Sie wirken, indem sie von einem Rezeptor auf der Oberfläche der Zielzelle erkannt werden. Nur Zellen, die den spezifischen Rezeptor für den jeweiligen Wachstumsfaktor (= Ligand) tragen, können auf das Signal reagieren. Dieser Rezeptor erzeugt bei Bindung an seinen Liganden durch Konformationsänderung im Inneren der Zelle ein Signal, das über weitere Signalübertragungen zu Aktivierung oder Abschaltung von Genen führt. PAN-Biotech bietet Ihnen eine hochwertige Auswahl an Cytokinen, Wachstumsfaktoren und darüber hinaus an Chemokinen, den chemotaktisch wirkenden Cytokinen („chemoattractant cytokines“), die von vielen Zelltypen, u. a. von Phagozyten und dendritischen Zellen, aber auch von Gewebezellen sezerniert werden können. Chemokine können Leukozyten anlocken und aktivieren. Sie spielen daher eine wichtige Rolle als Mediatoren bei der Regulation einer gerichteten Leukozytenwanderung und den dadurch ausgelösten Entzündungsprozessen. BIOTECH GmbH
Biologicals BIOTECH GmbH 6.2 Biologika Growth Factors/Wachstumsfaktoren Human (Hu) Cytokines and Growth Factors/Humane (Hu) Cytokine und Wachstumsfaktoren SHORT TERM DESCRIPTION CAT# SIZE 4-1BBr Hu 4-1BB Receptor rec. CB-1010100 5 μg CB-1010101 20 μg CB-1010102 1 mg Acrp30 Glob Hu Adiponectin Globular rec. CB-2800004 2 μg CB-2800005 10 μg CB-2800006 1 mg Acrp30 HEK Hu Adiponectin glycosilated, HEK rec. CB-2800007 2 μg CB-2800008 10 μg CB-2800009 1 mg Acrp30 Hu Adiponectin rec. CB-2800001 5 μg CB-2800002 25 μg CB-2800003 1 mg Acrp30 Tri Hu Adiponectin Trimeric Form rec. CB-2800010 2 μg CB-2800011 10 μg CB-2800012 1 mg Acrp30 His Hu Adiponectin, His tag rec. CB-2800013 10 μg CB-2800014 50 μg CB-2800015 1 mg AITRL Hu AITRL rec. CB-1001000 5 μg CB-1001001 20 μg CB-1001002 1 mg ANG-1 Hu Angiopoietin-1 rec. CB-1001003 2 μg CB-1001004 10 μg CB-1001005 1 mg ANG-2 Hu Angiopoietin-2 rec. CB-1001006 2 μg CB-1001007 10 μg CB-1001008 1 mg ANGPTL-3 Hu Angiopoietin-like Protein 3 rec. CB-1001009 2 μg CB-1001010 10 μg CB-1001011 1 mg ANGPTL-4 Hu Angiopoietin-like Protein 4 rec. CB-1001012 2 μg CB-1001013 10 μg CB-1001014 1 mg APO-J Hu Apoliprotein-J rec. CB-1001100 2 μg CB-1001101 10 μg CB-1001102 0.1 mg Artemin Hu Artemin rec. CB-1105002 5 μg CB-1105007 20 μg CB-1105008 1 mg BAFF Hu BAFF (BLyS) rec. CB-1010000 5 μg CB-1010001 20 μg CB-1010002 1 mg BAFF-R Hu BAFF (BlyS) Receptor rec. CB-1010003 5 μg CB-1010004 20 μg CB-1010005 1 mg BD-3 Hu Beta Defensin -3 rec. CB-1010006 5 μg CB-1010007 20 μg CB-1010008 1 mg BTC Hu Betacellulin rec. CB-1117100 5 μg CB-1117101 20 μg CB-1117102 1 mg BMPR1A Hu Bone Morphogenetic protein Receptor-1A rec. CB-1113000 2 μg CB-1113006 10 μg CB-1113007 1 mg 6
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