BUKU ABSTRAK - Universiti Putra Malaysia

Imaging in Nasopharyngeal Carcinoma: The Value of 18-Florine Fluorodeoxyglucose
PET/CT in comparison to Conventional Imaging Modalities CT and MRI
Assoc. Prof. Dr. Abdul Jalil Nordin
Simona Secondino, Noraini Abdul Rahim, Paolo Pedrazzoli, Salvatore Siena, Claudio Rossetti and Tahir Aris
Faculty of Medicine and Health Sciences, University Putra Malaysia,
43400 UPM Serdang, Selangor, Malaysia.
+603-8947 2607; drimaging@yahoo.com
The aim of the study was to evaluate the clinical usefulness of 18F fluorodeoxyglucose (FDG) positron
emission tomography/computed tomography (PET/CT) in the management of nasopharyngeal carcinoma (NPC)
in comparison to conventional imaging modalities. This retrospective study was done at Ospedale Niguarda,
Milan, Italy. Data were acquired from 24 NPC patients between May 2003 and December 2006. They had FDG
PET/CT and CT or MRI during the initial diagnosis and at follow-up. Each finding was tabulated and compared
with tissue biopsy at diagnosis and clinical status during the follow up after the therapy. A statistical calculation
was done to derive the value of each modality. The sensitivity and accuracy of PET/CT and CT/MRI were equally
high at diagnosis. At the follow up, a negative PET/CT finding suggested a complete remission with sensitivity
and negative predictive value of 100%. 18F FDG PET/CT is a potential modality to be utilised in following up
NPC patients for evaluating a response to therapy.
Keywords: Positron emission tomography, computed tomography, magnetic resonance imaging, na- sopharyngeal
carcinoma, follow-up
Potential False Positive Active Extra Pulmonary Tuberculosis Lesions on FDG
PET/CT Imaging in Malignancy
Assoc. Prof. Dr. Abdul Jalil Nordin
Hairil Rashmizal, Noraini Abdul Rahim and Claudio Rossetti
Faculty of Medicine and Health Sciences, University Putra Malaysia,
43400 UPM Serdang, Selangor, Malaysia.
+603-8947 2607; drimaging@yahoo.com
Integrated fusion imaging modality Positron Emission Tomography Computed Tomography (PET/CT) using
18Fluorine-Fluoro Deoxy Glucose (18F-FDG) is commonly utilised in imaging oncology. We expand the role of
this imaging modality in our study to demonstrate the appearance of active extra pulmonary tuberculosis (TB)
lesions. This study involved prospective evaluation of eight patients using 18F-FDG PET/CT with confirmed
diagnosis of extra pulmonary TB infection. Visually high intensity lesions in abnormal areas were studied where
the mean and maximum standardised uptake value (SUVmean and SUVmax) were tabulated. The diagnosis of
TB infection was confirmed by isolation of TB bacillus from these lesions or evidence of responding to anti TB
treatment during post treatment evaluation using FDG PET/CT at follow up. The genders are equally affected.
Majority of the group falls within young age below 50 years. Number of PET/CT studies demonstrating lesions
either singly or multiple were equal in distribution. Nodal involvement is the most common in our study including
mediastinum, paraaortic and inguinal groups. Other sites of infection include spine and bowel. The average
SUVmax and SUVmean for all lesions were 7.7 and 5.2 respectively. Active TB lesions are FDG avid. Thus, FDG
avid lesions should be interpreted with extra careful when FDG PET/CT are utilised in managing malignancy.
Keywords: Extra pulmonary tuberculosis, 18F-FDG PET/ CT, SUVmax, false positive, malignancy
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