BUKU ABSTRAK - Universiti Putra Malaysia

Science, Technology & Engineering
New Coumarins from Micromelum minutum (Rutaceae) as Potential Lead
Compounds for Anticancer Agents
Prof. Dr. Mawardi Rahmani
Ratna Asmah Susidarti, M. Aspollah Sukari, Taufiq-Yap Yun Hin, Gwendoline Ee Cheng Lian and Abdul Manaf
Ali
Faculty of Science, University Putra Malaysia,
43400 UPM Serdang, Selangor, Malaysia.
+603-8946 6794; mawardi@science.upm.edu.my
Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties
and their cytotoxic properties have been extensively examined. Micromelum minutum (G. Frost.) Wright and Arn
(Rutaceae) is one of the good sources of this class of compounds and petroleum ether and chloroform extracts of the
plant exhibited strong cytotoxic activity when tested against T-lymphoblastic leukemia cell line. Further isolation
of the extracts results in the isolation of five coumarins 3?,4?-dihydrocapnolactone, 2’,3’-epoxyisocapnolactone,
8-hydroxyisocapnolactone-2?,3?-diol, 8-hydroxy-3?,4?-dihydrocapnolactone-2?,3?-diol and 8,4?-dihydroxy-
3?,4?-dihydrocapnolactone-2?,3?-diol and two triterpenes. Some of these compounds were strongly active
against T-lymphoblastic leukemia (CEM-SS), promyeolocytic leukemia (HL60), cervical cancer (HeLa) and
liver cancer (HepG2) cell lines. 8-Hydroxyisocapnolactone-2?,3?-diol was found to be the most active with
IC50 values of 2.9, 2.5, 6.9 and 5.9 ?g/ml, respectively. This was followed by 2’,3’-epoxyisocapnolactone. When
evaluated against the normal mouse fibroblast (3T3) cell line, 8-hydroxyisocapnolactone-2?,3?-diol was found to
be inactive, hence could serve as valuable leads for further design and synthesis of more active analogues.
Keywords: Micromelum minutum, coumarins, cytotoxicity, cell lines
A New Algorithm for Divisible Load Schedulling with Different Processor Available
Times
Prof. Dr. Mohamed Othman
Amin Shokripour and Hamidah Ibrahim
Faculty of Computer Science and Information Technology, University Putra Malaysia,
43400 UPM Serdang, Selangor, Malaysia.
+603-8946 6535; shokripour@gmail.com
During the last decade, the use of parallel and distributed systems has become more common. In these
systems, a huge chunk of data or computation is distributed among many systems in order to obtain better
performance. Dividing data is one of the challenges in this type of systems. Divisible Load Theory (DLT) is a
proposed method for schedulling data distribution in parallel or distributed systems. In many researches carried
out in this field, it was assumed that all processors are dedicated for grid system but that is not always true in real
systems. The limited number of studies which attended to this reality assumed that systems are homogeneous
and presented some algorithms or closed-formulas for schedulling jobs in a System with Different Processors
Availability Time (SDPAT). In this article, we propose a new algorithm for schedulling jobs in a heterogeneous
SDPAT.
Keywords: Algorithm, schedulling, heterogeneous, different processors availability time, parallel computing
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