WHO Guidelines on Hand Hygiene in Health Care - Safe Care ...

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<strong>WHO</strong> GUIDELINES ON HAND HYGIENE IN HEALTH CARE Table I.11.5 Virucidal activity of antiseptic agents Reference Test method Viruses Agent Results Enveloped viruses Spire et al., 1984 467 Suspension HIV 19% EA LR=2.0 in 5 min Martin, McDougal & Suspension HIV 50% EA Loskoski, 1985 468 35% IPA LR>3.5 LR>3.7 Resnick et al., 1986 469 Suspension HIV 70% EA LR=7.0 in 1 min van Bueren, Larkin & Suspension HIV 70% EA LR= 3.2–5.5 in 30 s Simpson, 1994 470 Montefiori et al., 1990 471 Suspension HIV 70% IPA + 0.5% CHG 4% CHG Wood & Payne 1998 472 Suspension HIV Chloroxylenol Benzalkonium chloride Harbison & Hammer, Suspension HIV Povidone-iodine 1989 473 CHG Lavelle et al., 1989 474 Suspension HIV Detergent + 0.5% chloroxylenol LR= 6.0 in 15 s LR= 6.0 in 15 s Inactivated in 1 min Inactivated in 1 min Inactivated Inactivated Inactivated in 30 s Bond et al., 1983 475 Kobayashi et al., 1984 476 Suspension/dried plasma Chimpanzee challenge Suspension/plasma Chimpanzee challenge HBV 70% IPA LR= 6.0 in 10 min HBV 80% EA LR= 7.0 in 2 min Kurtz, 1979 477 Suspension HSV 95% EA 75% EA 95% IPA 70% EA + 0.5% CHG Platt & Bucknall, 1985 297 Suspension RSV 35% IPA 4% CHG LR>5.0 in 1 min LR>5.0 LR>5.0 LR>5.0 LR>4.3 in 1 min LR>3.3 Schurmann & Eggers, Suspension Influenza 1983 309 Vaccinia Schurmann & Eggers, Hand test Influenza 1983 309 Vaccinia 95% EA 95% EA 95% EA 95% EA Undetectable in 30 s Undetectable in 30 s LR> 2.5 LR> 2.5 42
PART I. REVIEW OF SCIENTIFIC DATA RELATED TO HAND HYGIENE Table I.11.5 Virucidal activity of antiseptic agents (Cont.) Reference Test method Viruses Agent Results Non-enveloped viruses Sattar et al., 1983 478 Suspension Rotavirus 4% CHG 10% Povidone-iodine 70% IPA/0.1% HCP LR3.0 LR>3.0 Schurmann & Eggers, 1983 309 Hand test Adenovirus Poliovirus Coxsackie 95% EA 95% EA 95% EA LR>1.4 LR=0.2–1.0 LR=1.1–1.3 Finger test Adenovirus Poliovirus Coxsackie 95% EA 95% EA 95% EA LR>2.3 LR=0.7–2.5 LR=2.9 Kurtz, 1979 477 Suspension ECHO virus 95% EA 75% EA 95% IPA 70% IPA+0.5%CHG Mbithi, Springthorpe & Sattar, 2000 308 Fingerpad HAV 70% EA 62% EA foam Plain soap 4% CHG 0.3% Triclosan Bellamy et al., 1993 272 Fingertips Bovine rotavirus n-propanol+IPA 70% IPA 70% EA 2% Triclosan Water (control) 7.5% povidone-iodine Plain soap 4% CHG Ansari et al., 1991 257 Fingerpad Human rotavirus 70% IPA Plain soap Ansari et al., 1989 304 Fingerpad Human rotavirus 70% IPA Plain soap LR>3.0 in 1 min LR3.0 in 10 s LR>3.0 LR>3.0 Steinmann et al., Fingerpad Poliovirus 70% EA 1995 307 70% IPA Davies, Babb & Bradley, Fingertips Poliovirus Plain soap 1993 372 80% EA LR=1.6 in 10 s LR=0.8 LR=2.1 LR=0.4 HIV = human immunodeficiency virus; EA = ethanol; LR = Log 10 Reduction; IPA = isopropanol; CHG = chlorhexidine gluconate; HBV = hepatitis B virus; RSV = respiratory syncytial virus; HSV = herpes simplex virus; HAV = hepatitis A virus. 43
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PART II. CONSENSUS RECOMMENDATIONS
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PART III. PROCESS AND OUTCOME MEASU
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PART IV. TOWARDS A GENERAL MODEL OF
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PART V. PATIENT INVOLVEMENT IN HAND
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PART VI. COMPARISON OF NATIONAL AND
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REFERENCES 35. Jroundi I et al. Pre
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REFERENCES 109. Boyce JM et al. Out
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REFERENCES 177. McBryde ES, Pettitt
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REFERENCES 250. Squier C, Yu VL, St
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REFERENCES 327. Rotter ML, Koller W
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REFERENCES 400. McMurry LM, McDermo
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REFERENCES 468. Martin LS, McDougal
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REFERENCES 542. Wheelock SM, Lookin
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REFERENCES 615. Voss A, Widmer AF.
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REFERENCES 690. Saba R et al. Hand
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REFERENCES 765. Lee B, Newberg A. R
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REFERENCES 841. Gillet P. Construir
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REFERENCES 915. De Groot-Kosolcharo
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REFERENCES 986. Kinsella G, Thomas
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REFERENCES 1062. Runciman WB, Molle
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REFERENCES 1138. Chen YC, Chiang LC
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