AstraZeneca Annual Report and Form 20-F Information 2011

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Therapy Area ReviewThis section contains further information aboutthe Therapy Areas in which our efforts arefocused: Cardiovascular, Gastrointestinal,Infection, Neuroscience, Oncology, andRespiratory & Inflammation.We describe the business environment, trends and other factors thathave influenced our decision to focus on diseases in these six areas,our strategic objectives for each and our progress towards achievingthese objectives. We include information about our marketedmedicines and how they are designed to make a meaningfuldifference for patients, together with an overview of performanceSales by Therapy Areaduring the year. We also report in detail on the potential new productsand product life-cycle developments in our pipeline that reflect ourcommitment to maintaining a flow of innovation that adds value forour shareholders and to society.For a list of all our potential new products and product life-cycledevelopments see the Pipeline by Therapy Area at 31 December 2011table on page 57 and the Development Pipeline table from page 199.For details of patent expiries of our key marketed products, see thePatent expiries section on page 35.Many of our products are subject to litigation. Information aboutmaterial legal proceedings can be found in Note 25 to the FinancialStatements from page 184. Details of relevant risks are set out in thePrincipal risks and uncertainties section from page 130.References to months in this section refer to months in 2011, unlessotherwise stated.Sales$m2011 2010 2009Reportedgrowth%CERgrowth%Sales$mReportedgrowth%Cardiovascular 10,212 9 5 9,403 12 11 8,376Gastrointestinal 5,536 (9) (11) 6,088 1 – 6,011Infection and other* 1,856 (15) (15) 2,176 (17) (18) 2,631Neuroscience 7,204 7 5 6,704 7 7 6,237Oncology 3,705 (8) (12) 4,045 (10) (12) 4,518Respiratory & Inflammation 4,468 9 6 4,099 (1) (1) 4,132Other businesses** 610 (19) (22) 754 (16) (15) 899Total 33,591 1 (2) 33,269 1 – 32,804* Represents all other pharmaceutical product sales that are not in our six Therapy Areas.** Represents sales by Astra Tech of $386m (2010: $535m) and Aptium Oncology of $224m (2010: $219m). Astra Tech was sold to DENTSPLY International Inc. on 31 August 2011. Further details onthese two businesses are included on page 22.CERgrowth%Sales$m56 Therapy Area ReviewAstraZeneca Annual Report and Form 20-F Information 2011
Pipeline by Therapy Area at 31 December 2011Phase IPhase IIPhase III/RegistrationLineExtensionsCardiovascular> AZD2820 # > AZD2927> AZD4017> Brilinta/Brilique > Axanum> dapagliflozin # > Brilinta/BriliquePEGASUS-TIMI> Crestor #(elevated CRP)> dapagliflozin/metformin FDC #> dapagliflozin #(diabetes – add onto DPP-IV)> dapagliflozin #(diabetes – add on to insulinand add on to metforminLT data)> dapagliflozin #(diabetes – in patients withhigh CV risk – Study 18 and19 data)> Kombiglyze XR TM /Komboglyze TM FDC # *> Onglyza TMSAVOR-TIMI #GastrointestinalInfection> tralokinumab(CAT-354)> AZD5099> AZD5847> MEDI-534> MEDI-550> MEDI-557> MEDI-559> AZD9773 #> CXL #(CEF104)> CAZ AVI #(CAZ104)> Q-LAIV Flu Vac(MEDI-3250)> Zinforo #(ceftaroline)> Entocort> Nexium(peptic ulcer bleeding)> Nexium(GERD)> FluMist/FluenzBusiness ReviewNeuroscience > AZD1446 #> AZD3241> AZD3839 #> AZD5213> MEDI-578> AZD2423> AZD3480 #> AZD6765> TC-5214 #(monotherapy)> NKTR-118 #> TC-5214 #(adjunct)> Diprivan #> EMLA #Oncology> AZD1480 > MEDI-3617 #> AZD2014 > moxetumomab> AZD3514 pasudotox #> AZD5363 # (CAT-8015)> AZD8330 # > olaparib(ARRY-424704) > selumetinib #> MEDI-551 # (AZD6244)> MEDI-565 # (ARRY-142886)/MK2206> MEDI-573 #> AZD4547> Caprelsa> AZD8931(vandetanib)> fostamatinib # ** > Ranmark TM #> MEDI-575 #(denosumab)> selumetinib #(AZD6244)(ARRY-142886)> tremelimumab #> Faslodex(high dose (500mg)2nd line advancedbreast cancer)> Faslodex(1st line advancedbreast cancer)> Iressa(1st line EGFRmut+ NSCLC)> Iressa(treatment beyondprogression)Respiratory &Inflammation> AZD2115> AZD1981> MEDI-546 #> AZD2423> MEDI-551 #> AZD5069> MEDI-570 # > AZD5423> AZD8683> benralizumab #(MEDI-563)> mavrilimumab #(CAM-3001)> MEDI-8968 #> sifalimumab #(MEDI-545)> tralokinumab(CAT-354)> fostamatinib # > Oxis> Symbicort(asthma/COPD)> Symbicort(COPD)> Symbicort(SMART)Key – showing movements since 27 January 2011AdditionNo changeProgressionNew filingLaunchedReclassified# Partnered product.* Kombiglyze XR TM in the US; Komboglyze TM FDC in the EU.** Added to pipeline table after starting Phase II in January 2012.AstraZeneca Annual Report and Form 20-F Information 2011Therapy Area Review 57
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healthAstraZeneca Annual Reportand
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Financial summary$33.6bnSales down
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China: We announcedour decision to
Page 7 and 8: OverviewOperational overview7979 pr
Page 9 and 10: Chairman’s StatementI would like
Page 11 and 12: Chief Executive Officer’s ReviewA
Page 13 and 14: The process of getting a drug to ma
Page 15 and 16: OverviewnovationInnovation drives p
Page 17 and 18: Our Strategy and PerformanceMore pe
Page 19 and 20: Using the full range of innovative
Page 21 and 22: Our strategyMissionto make the most
Page 23 and 24: Our strategic priorities to 2014Our
Page 25 and 26: Our performance in 2011Our performa
Page 27 and 28: Business shapePeopleResponsible bus
Page 29 and 30: Strategy and PerformanceaborationIm
Page 31 and 32: Delivering our strategyOur strategy
Page 33 and 34: Development projects20112010 129342
Page 35 and 36: Investing in capabilitiesA core com
Page 37 and 38: Patent expiries for our key markete
Page 39 and 40: our Established Markets footprint i
Page 41 and 42: Product qualityWe are committed to
Page 43 and 44: We have a global approach, supporte
Page 45 and 46: ComplianceWe ensure a culture of et
Page 47 and 48: tegrityBusiness ReviewWe are dedica
Page 49 and 50: Delivering our strategyResponsible
Page 51 and 52: India has the fastest growing numbe
Page 53 and 54: ProtestsAstraZeneca acknowledges th
Page 55 and 56: Also in 2011, the DIHR in collabora
Page 57: healthcollaborationRaising breast c
Page 62 and 63: Therapy Area ReviewIn September, we
Page 64 and 65: Therapy Area ReviewGastrointestinal
Page 66 and 67: Therapy Area ReviewInfectionTherapy
Page 68 and 69: Therapy Area ReviewIn the pipelineI
Page 70 and 71: Therapy Area ReviewOur financial pe
Page 72 and 73: Therapy Area ReviewOncologyTherapy
Page 74 and 75: Therapy Area Reviewendpoints of pro
Page 76 and 77: Therapy Area ReviewOur financial pe
Page 78 and 79: healthinnovationReducing the number
Page 80 and 81: Geographical ReviewUSAstraZeneca is
Page 82 and 83: Geographical ReviewEmerging Markets
Page 84 and 85: Disciplined execution of our strate
Page 86 and 87: Financial ReviewMeasuring performan
Page 88 and 89: Financial ReviewResults of operatio
Page 90 and 91: Financial ReviewFinancial position
Page 92 and 93: Financial ReviewCapitalisation and
Page 94 and 95: Financial ReviewResults of operatio
Page 96 and 97: Financial ReviewSensitivity analysi
Page 98 and 99: Financial Reviewover the performanc
Page 100 and 101: healthcollaborationFighting the ris
Page 102 and 103: Board of Directors and Senior Execu
Page 104 and 105: Board of Directors and Senior Execu
Page 106 and 107: Corporate Governance ReportOperatio
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Corporate Governance ReportThe Boar
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Corporate Governance ReportDuring 2
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Corporate Governance ReportBusiness
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Corporate Governance ReportPolitica
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Directors’ Remuneration ReportDav
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Directors’ Remuneration ReportVar
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Directors’ Remuneration ReportAdd
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Directors’ Remuneration ReportSum
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Directors’ Remuneration ReportSum
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Directors’ Remuneration ReportIn
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Directors’ Remuneration ReportPer
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Directors’ Remuneration ReportGai
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RiskManagement reporting and assura
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RiskCommercialisation and business
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RiskCommercialisation and business
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RiskSupply chain and delivery risks
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RiskEconomic and financial risks co
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Financial StatementsPreparation of
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Financial StatementsConsolidated St
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Financial StatementsConsolidated St
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Financial StatementsGroup Accountin
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Financial StatementsProperty, plant
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Financial StatementsNotes to the Gr
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Financial Statements3 Finance incom
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Financial Statements4 Taxation cont
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Financial Statements6 Segment infor
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Financial Statements9 Intangible as
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Financial Statements10 Other invest
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Financial Statements15 Financial in
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Financial Statements15 Financial in
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Financial Statements18 Post-retirem
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Financial Statements18 Post-retirem
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Financial Statements20 Share capita
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Financial Statements23 Financial ri
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Financial Statements23 Financial ri
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Financial Statements24 Employee cos
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Financial Statements25 Commitments
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Financial Statements26 LeasesTotal
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Financial StatementsIndependent Aud
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Financial StatementsCompany Account
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Financial Statements4 ReservesShare
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Financial StatementsGroup Financial
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Development PipelineNCEsPhase III/R
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Development PipelineNCEsPhases I an
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Shareholder Information> For shares
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Shareholder InformationDocuments on
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Corporate InformationHistory and de
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GlossaryThe following abbreviations
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Index2011 performance summary 23Acc
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Contact informationRegistered offic
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AstraZeneca Annual Report and Form 20-F Information 2011

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