Research Group Heussler (Malaria I) - Bernhard-Nocht-Institut für ...

Symposia and Meetings
2002
Symposia
August 29 th -31 st , 2002 Expert meeting
„Proteins of the redox metabolism as targets for the development of new drugs
against malaria and other protozoan infections“
European Commission COST Action B9
Meeting organizers: Rolf D. Walter, Luise Krauth-Siegel, Eva Liebau, Sylke Müller
Chairman of the COST B9 Action: Fred Opperdoes
Session 1: Redox metabolism and validation of potential drug targets
C.H. Williams (Ann Arbor, USA): “Catalytic mechanism of the high molecular weight thioredoxin
reductase”
Heiner Schirmer (Heidelberg, Germany): “Glutathione reductase: structure and inhibition”
Katja Becker-Brandenburg (Gießen, Germany): “Thioredoxin and glutaredoxin in
Plasmodium falciparum”
Sylke Müller (Dundee, UK): “Validation of thioredoxin reductase as a drug target in
Plasmodium falciparum”
Sandra Oza (Dundee, UK): “The synthesis of trypanothione as a potential drug target”
Leopold Flohe (Braunschweig, Germany): “Tryparedoxin and tryparedoxin peroxidase”
Daniel Dive (Lille, France): “Superoxide dismutase in Plasmodium”
Fred Opperdoes (Brussels, Belgium): “Identification of a potential glycosomal ascorbate
peroxidase gene in Trypanosoma brucei”
Session 2: Detoxification and drug resistance
Paul J. Thornalley (Colchester, UK): “The glyoxalase system. Glyoxalase I inhibitors as
antitumor (and antimalarial) agents”
Luise Krauth-Siegel (Heidelberg, Germany): “The glyoxalase system in trypanosomatids”
Eva Liebau (Hamburg, Germany): “Glutathione dependent detoxification processes in
Plasmodium”
Marc Ouellette (Quebec, Canada). “Drug resistance related to thiol metabolism”
Iris Bruchhaus (Hamburg, Germany): “Metronidazole resistance in Entamoeba
(including aspects of the redox metabolism in anaerobic protozoa)”
Graham Coombs (Glasgow, UK): “The thioredoxin system of Trichomonas vaginalis”
Session 3: Target structures, drug design and screening
Koen Augustyns (Antwerps, Belgium): “Trypanothione as target in the design of antitrypanosoma
and antileishmanial agents”
Ken T. Douglas (Manchester, UK): “Design of trypanothione reductase inhibitors”
Elisabeth Davioud-Charvet (Lille, France): “Naphthoquinones as inhibitors of trypanothione
reductase”
Christof Werner (Marburg, Germany): “Structure of the P. falciparum glutamate dehydrogenase”
Narimantas Cenas (Vilnius, Littauen): “Antiplasmodial activity of nitroaromatic and quinoidal
compounds”
C.W. Jefford (Geneva, Switzerland): “Artemisinin and derivatives”
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