Research Group Heussler (Malaria I) - Bernhard-Nocht-Institut für ...

More documents

Recommendations

Info

General Information Board of Directors / Kuratorium Staatsrat Gregor Kempkens Chairman from 11/2001-03/2004 Behörde für Umwelt und Gesundheit Freie und Hansestadt Hamburg Thomas Delissen Finanzbehörde Freie und Hansestadt Hamburg Hanna Fangohr Behörde für Wissenschaft und Forschung Freie und Hansestadt Hamburg PD Dr. Michael Kramer Bundesministerium für Gesundheit und Soziale Sicherung Scientific Advisory Board / Wissenschaftlicher Beirat Prof. Dr. Jürgen Heesemann Chairman Max-von-Pettenkofer-Institut für Hygiene und Mikrobiologie, Universität München Prof. Dr. Philippe Sansonetti, Vice Chairman Unité de Pathogénie Microbienne Moléculaire Institut nationale de la santé et de la recherche médicale (INSERM) Institut Pasteur, Paris, France Prof. Dr. Roy Anderson Department of Infectious Diseases Epidemiology Imperial College School of Medicine London, United Kingdom Prof. Dr. Bruno Gryseels Prins Leopold Instituut voor tropische Geneeskunde Antwerp, Belgium 6 Prof. Dr. Angelika Vallbracht Institut für Virologie Universität Bremen PD Dr. Peter Lange Bundesministerium für Bildung und Forschung Senatsdirektor Norbert Lettau Behörde für Umwelt und Gesundheit Freie und Hansestadt Hamburg Ministerialdirigent Arnold Schreiber Bundesministerium für Gesundheit und Soziale Sicherung Prof. Dr. Thomas Hünig Institut für Virologie und Immunbiologie der Universität Würzburg Prof. Dr. Rainer Laufs Institut für Medizinische Mikrobiologie und Immunologie Universitätsklinikum Hamburg-Eppendorf Prof. Eric Ottesen, MD Robert W. Woodruff Health Sciences Center Emory University, Atlanta, USA Prof. Dr. Dietmar Richter Institut für Zellbiochemie und Klinische Neurobiologie Universitätsklinikum Hamburg-Eppendorf
Introduction The appearance of SARS during this reporting period has again demonstrated how suddenly infectious diseases can emerge and how fast a new infection can spread from one continent to the next. The Bernhard Nocht Institute (BNI) played an important role in the worldwide network against SARS culminating in the identification of the SARS Coronavirus by BNI members. Other highlights of these two years were the successful evaluation of the BNI by the Leibniz Association and the construction of the buildings for the Kumasi Centre for Collaborative Research (KCCR) in Ghana. The Bernhard Nocht Institute Founded on 1st October 1900 as Institute for Maritime and Tropical Diseases the BNI is still Germany’s largest research institute for tropical medicine and still connects laboratory research with clinical studies and patient care under one roof. The BNI is a government institution affiliated to the Federal Ministry of Health and the Ministry of Health of the State of Hamburg and is financed jointly by the Federal Government and the States of the Federal Republic of Germany. It is a member of the Leibniz Association that comprises institutes of national scientific impact. The BNI has approx. 350 members (including the staff of the Clinical Department, the diploma students and guests working for short time periods), it has 30 staff scientist positions and employs altogether 87 scientists including PhD students. Mission of the BNI As the German centre for research in tropical medicine the Bernhard Nocht Institute is dedicated to research, training and medical care in the area of human infectious diseases which are of particular relevance in the tropics. It is the primary mission of the BNI to develop means for the control of these diseases. Secondary missions are to provide expertise for regional and national authorities and to (directly and indirectly) improve health care for national and regional citizens in regard to diseases of the tropics. A clinical department with 62 beds and an out-patient clinic where patients with tropical infections are treated is an integral part of the BNI. The hospital and its staff are entirely financed by health insurances. There is a travel medicine centre associated with the hospital to advise travellers on prophylaxis. The Central Diagnostic Unit of the BNI performs specialized diagnostic tests for the detection of tropical viruses and pathogens causing parasitic diseases. The unit serves as the National Reference Centre for Tropical Infections for Germany. For work with haemorrhagic fever viruses there is a biosafety level 4 laboratory available in the BNI. The BNI has multiple educational activities. It is engaged in postgraduate training in the area of tropical 7 Introduction medicine. In the reporting, period 24 diploma theses and 34 doctoral theses were completed, a record in the history of the BNI. Seventeen members of the BNI are teaching at the University of Hamburg at the Faculties of Medicine, Biology and Chemistry. Three members of the institute hold full professorships (for Molecular Parasitology, Immunology and Molecular Tropical Medicine) at the University of Hamburg. A three-month's course on tropical medicine is held each year that is approved as an officially accredited diploma course by the German Medical Board and the American Society of Tropical Medicine and Hygiene. Research The Institute conducts disease-oriented basic research and applies contemporary techniques of cell biology, molecular genetics and immunology to the characterization of host-pathogen-interactions in tropical infectious diseases. The research activities of the BNI concentrate on three areas: (1) cellular and molecular biology of infectious agents that cause tropical diseases, (2) the host response to those agents and its role in protection and pathology, and (3) a disease oriented approach to pathogenesis and pathology. Accordingly, the studies focus on infectious diseases caused by parasites and tropical viruses. Main topics of work are pathogenicity factors and cell biology of parasites, the analysis of the host-parasite-interaction including immunological defence mechanisms, and the definition of genes causing susceptibility to certain tropical infections. In all these ventures, special emphasis is put on two issues: relevance for disease, prevention and control, and use of tropical infections as models for general issues in medicine and biology. Organization To fulfil these aims the BNI has a specific organizational structure. Three scientific sections (Parasitology, Medical Microbiology, Tropical Medicine) contain departments established for longer periods of time and temporary research groups and closely associated is a Clinical Department. Research groups are usually installed for a limited period of time only and will be replaced by new groups according to scientific necessity. The Parasitology Section contains the Departments of Molecular Parasitology and of Biochemistry and several research groups working on pathogenicity factors, biology of pathogens including biochemical pathways and mechanisms of adaptation and evasion. The Medical Microbiology Section contains the Departments of Immunology working on host-responses to parasites, the Department of Virology, concentrating mostly on tropical viruses, the Department of Helminthology (until 2003), a Central Diagnostic Unit acting as National Reference Centre for Tropical Infections and the animal experimentation facilities. The Tropical Medicine Sec-
Page 1 and 2: BERNHARD NOCHT INSTITUTE FOR TROPIC
Page 3 and 4: Human genetic variants influencing
Page 5: Research Funding / Haushaltsmittel
Page 9 and 10: tive project with the Faculty of Me
Page 11 and 12: since this group headed by Dr. Chri
Page 13 and 14: Vorwort Das Erscheinen der schweren
Page 15 and 16: AIDS-Forschung hat eine lange zurü
Page 17 and 18: europäisches Konsortium mit 8 Part
Page 19 and 20: Parasitology Section Selected Scien
Page 21 and 22: Zusammenfassung des Sprechers Die S
Page 23 and 24: Research Group Clos (Leishmaniasis
Page 25 and 26: Figure 2: Incidence of ALA in Hué
Page 27 and 28: jects were assigned to receive dilo
Page 29 and 30: is increased in the first 24 h of h
Page 31 and 32: the populations from the endemic ar
Page 33 and 34: CQR Dd2. In order to determine whet
Page 35 and 36: Project Description and Results A g
Page 37 and 38: Project Description and Results Ado
Page 39 and 40: 39 Parasitology Section Figure 2: S
Page 41 and 42: The paraflagellar rod, a crosshatch
Page 43: Figure 1: Suggested in vivo develop
Page 46 and 47: Medical Microbiology Section Chairm
Page 48 and 49: Medical Microbiology Section Zusamm
Page 50 and 51: Medical Microbiology Section Medica
Page 52 and 53: Medical Microbiology Section Zusamm
Page 54 and 55: Medical Microbiology Section Murine
Page 56 and 57:
Medical Microbiology Section The ro
Page 58 and 59:
Medical Microbiology Section Zusamm
Page 60 and 61:
Medical Microbiology Section Immunp
Page 62 and 63:
Medical Microbiology Section Role o
Page 64 and 65:
Medical Microbiology Section Elimin
Page 66 and 67:
Medical Microbiology Section Charac
Page 68 and 69:
Medical Microbiology Section Identi
Page 70 and 71:
Medical Microbiology Section A dry-
Page 73 and 74:
Tropical Medicine Section Selected
Page 75 and 76:
Zusammenfassung des Sektionsspreche
Page 77 and 78:
Kumasi Centre for Collaborative Res
Page 79 and 80:
Data of twin studies and evidence f
Page 81 and 82:
Figure 1: Changing patterns of mala
Page 83 and 84:
Zusammenfassung In einer Studie an
Page 85 and 86:
low level chronic replication of th
Page 87 and 88:
The KCCR Team and the main laborato
Page 89 and 90:
Kooperierende Institutionen • Kwa
Page 91:
Figure 2: Study sites in and around
Page 94 and 95:
Clinical Department Department Head
Page 96 and 97:
Clinical Department Bericht des Abt
Page 98 and 99:
Clinical Department Staff Clinical
Page 100 and 101:
Clinical Department Cardiac impairm
Page 102 and 103:
Clinical Department Persistence and
Page 104 and 105:
106
Page 106 and 107:
Administration and Public Relations
Page 108 and 109:
Administration and Public Relations
Page 110 and 111:
112
Page 112 and 113:
Education and Teaching Diploma Thes
Page 114 and 115:
Education and Teaching Parasitology
Page 116 and 117:
Education and Teaching Lars Volkman
Page 118 and 119:
Education and Teaching The objectiv
Page 120 and 121:
Education and Teaching Ziel des Kur
Page 122 and 123:
Education and Teaching Institute Fa
Page 124 and 125:
Education and Teaching Lectures and
Page 126 and 127:
Education and Teaching Training for
Page 128 and 129:
Seminar Programme 2002 Prof. Aileen
Page 130 and 131:
Seminar Programme Dr. Stefan Martin
Page 132 and 133:
Symposia and Meetings 2002 Symposia
Page 134 and 135:
Symposia and Meetings 2003 May 13 t
Page 136 and 137:
138
Page 138 and 139:
Staff Activities Staff Activities A
Page 140 and 141:
Staff Activities PD Dr. Joachim Clo
Page 142 and 143:
Staff Activities Editorial Activiti
Page 144 and 145:
Staff Activities Prof. Dr. Rolf Hor
Page 146 and 147:
Staff Activities Prof. Dr. Christia
Page 148 and 149:
Staff Activities Prof. Dr. Egbert T
Page 150 and 151:
152
Page 152 and 153:
Publications Book chapters and Mono
Page 154 and 155:
Publications Herbst R, Ott C, Jacob
Page 156 and 157:
Publications Supali T, Wibowo H, Ru
Page 158 and 159:
Publications Scholze H and Tannich
Page 160 and 161:
Publications Graefe SE, Meyer BS, M
Page 162 and 163:
Publications Schulz A, Mellenthin K
Page 164 and 165:
166
Page 166 and 167:
Appendix 01. Januar 2002 Das BNI wi
Page 168 and 169:
Appendix 01. Oktober 2002 Gemeinsam
Page 170 and 171:
Appendix 01. April 2003 Ergebnis de
Page 172 and 173:
Appendix 01. Juni 2003 Fernsehrepor
Page 174 and 175:
Appendix November 2003 Inauguration
Page 176 and 177:
Appendix red by solar energy could
Page 178 and 179:
Appendix Ansprache von Dr. Thomas F
Page 180 and 181:
Diary 2004/2005 12.-14. November 20
show all

Research Group Heussler (Malaria I) - Bernhard-Nocht-Institut für ...

Create successful ePaper yourself

Delete template?

Save as template?