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Nondestructive testing of defects in adhesive joints

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is shown <strong>in</strong> table 2. Curcum<strong>in</strong> addition substantially <strong>in</strong>creased the tensile strength and modulus <strong>of</strong> the<br />

resultant system. A considerable decrease <strong>in</strong> the fracture stra<strong>in</strong> is observed with curcum<strong>in</strong> load<strong>in</strong>g.<br />

Results <strong>in</strong>dicate that curcum<strong>in</strong> acts as a re<strong>in</strong>forc<strong>in</strong>g agent <strong>in</strong> EVA matrix. Effect <strong>of</strong> tensile strength on<br />

short term age<strong>in</strong>g <strong>of</strong> EVA and curcum<strong>in</strong> loaded EVA <strong>in</strong> PBS is shown <strong>in</strong> figure 3. The system tends<br />

to be stable dur<strong>in</strong>g age<strong>in</strong>g except for that conta<strong>in</strong><strong>in</strong>g 10wt% curcum<strong>in</strong>. Contact angle data obta<strong>in</strong>ed for<br />

EVA and curcum<strong>in</strong> loaded EVA shows no significant changes <strong>in</strong> contact angle data with curcum<strong>in</strong><br />

load<strong>in</strong>g (figure 4). Matrices exhibited <strong>in</strong>crease <strong>in</strong> water uptake with higher curcum<strong>in</strong> load<strong>in</strong>gs. Water<br />

uptake behavior is shown <strong>in</strong> figure 5 with respect to curcum<strong>in</strong> content <strong>in</strong> the EVA matrix. Increases <strong>in</strong><br />

curcum<strong>in</strong> content <strong>in</strong>creased water uptake by the polymer matrix.<br />

3.2. Elution pr<strong>of</strong>ile <strong>of</strong> curcum<strong>in</strong><br />

Cumulative release <strong>of</strong> curcum<strong>in</strong> from EVA40 is shown <strong>in</strong> figure 6. Different concentrations<br />

<strong>of</strong> curcum<strong>in</strong> were loaded <strong>in</strong> the matrix and release was monitored upto 15days. The quantity <strong>of</strong><br />

curcum<strong>in</strong> released is a function <strong>of</strong> curcum<strong>in</strong> loaded <strong>in</strong> the matrix.<br />

Conclusion<br />

EVA copolymer is found to be a suitable system for the susta<strong>in</strong>ed release <strong>of</strong> curcum<strong>in</strong>.<br />

Curcum<strong>in</strong> released from the matrix depended on the quantity <strong>of</strong> curcum<strong>in</strong> loaded <strong>in</strong> it.<br />

References<br />

1. International Cardiovascular Disease Statistics, American Heart Association, 2007.<br />

2. Express Healthcare Management, Indian Express Newspapers Ltd., India, 2001.<br />

3. Gupta R, Misra A, Pais P, Rastogi P, Gupta VP. International Journal <strong>of</strong> Cardiology 2006; 108 (3):<br />

291-300.<br />

4. Boehm M and Nabel EG. Progress <strong>in</strong> Cell Cycle Research; 2003; 5; 19-30.<br />

5. Pan CJ, Tang JJ, Shao ZY, Wang J and Huang N. Colloids and Surfaces B: Bio<strong>in</strong>terfaces 2007;<br />

59 (1):105-111.<br />

6. Pan CJ, Tang JJ, Weng YJ, Wang J, Huang N. Journal <strong>of</strong> Controlled Release 2006; 116(1): 42-49.<br />

7. Guo Q, Guo S, Wang Z. Journal <strong>of</strong> Controlled Release 2007:118(3):318-324.<br />

8. Tambe S, S<strong>in</strong>gh SK, Patri M, Kumar D. Progress <strong>in</strong> Organic Coat<strong>in</strong>gs 2008;62 (4):382-386.<br />

_________________________________________________________________________________<br />

Table 1. Mechanical Properties <strong>of</strong> EVA grades<br />

Polymer grade<br />

Tensile strength<br />

(MPa)<br />

Elongation at<br />

break (%)<br />

Modulus<br />

(MPa)<br />

EVA -12 11.97 ± 0.99 2790 ± 207 5.28 ± 0.61<br />

EVA -18 8.44 ± 0.54 1183 ± 92 19.97 ± 2.19<br />

EVA -28 13.50 ± 1.19 1723 ±129 5.00 ± 1.37<br />

EVA -40 8.81 ± 0.20 2610 ± 97 0.56 ± 0.05<br />

4

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