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434 8 Food Additives

Fig. 8.4. Model of a sweetness receptor according to Nofre and Tinti (1996). a) Possible interactions of a sweet

substance with the receptor. Interactions of the receptor with b) glucose, c) sucrose and d) lugduname

is 0–2.5mg/kg of body weight. The synthesis

of saccharin usually starts with toluene (Remsen/Fahlberg

process, Formula 8.4) or sometimes

with the methyl ester of anthranilic acid (Maumee

process, Formula 8.5).

8.8.3 Cyclamate

Cyclamate is a widespread sweetener and is marketed

as the Na- or Ca-salt of cyclohexane sulfamic

acid. The sweetening strength is substan-

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