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1.2 Amino Acids 27

Table 1.6. Mutagenic compounds from pyrolysates of amino acids and proteins

Mutagenic compound Short form Pyrolized Structure

compound

3-Amino-1,4-dimethyl-

5H-pyrido[4,3-b]indole

Trp-P-1

Tryptophan

3-Amino-1-methyl-

5H-pyrido[4,3-b]indole

Trp-P-2

Tryptophan

2-Amino-6-methyldipyrido

[1,2-a:3’,2’-d]imidazole

Glu-P-1

Glutamic acid

2-Aminodipyrido[1,2-a:3’,2’-d]

imidazole

Glu-P-2

Glutamic acid

3,4-Cyclopentenopyrido[3,2-a]

carbazole

Lys-P-1

Lysine

4-Amino-6-methyl-1H-2,5,10,

10b-tetraazafluoranthene

Orn-P-1

Ornithine

2-Amino-5-phenylpyridine Phe-P-1 Phenylalanine

2-Amino-9H-pyrido[2,3-b]

indole

AαC

Soya globulin

2-Amino-3-methyl-9Hpyrido[2,3-b]

indole

MeAαC

Soya globulin

of tobacco smoke. They are formed by a reaction

of tryptophan and formaldehyde or acetaldehyde:

(1.57)

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