Pharmaceutical Manufacturing Handbook: Production and

1000
TABLE 6 Formulations by Wet Granulation
F15 F16 F17 F18 F19 F20 F21 F22 F23 F24 F25 F26 F27 F28 F29 F30
Extract
a 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50
a Lactose — — 20 16 a 16 a 22 a 27 a 29 a 32 a 42 a
32 a + 10 35
a 35 a 35 a 35 a 30 a
CMM 20
a 20 a
NaCl 20 a
15 a + 5 10 a 5 a 5 a 5 5 5 5 — — — 5
PEG6000 — — — — — — — — — — — — — 5 5 5
PEG400 a — — — — — — — — — — — — — 4
a Na 2 CO 3 — — — 5 + 5 10 a 5 5 5 5 — — 5 — — — 5
CMCNa — — 5
PVP a 5 5 5 4 4 4 4 4 4 4 4 4 4 4 4
SDS 2 a
1 a + 1 1 a + 1 1 1 2 2 2 2 2 2 2 2 2
Talc 1 1 — 1 1 2 2 2 2 4 4 4 4 4 4 4
MgEs 1 1 1 1 1
Aerosil 1 1 5 a + 2 5 a + 2 5 a a
+ 2 5
Acdisol — — — 5 5 5
a 5 3
% 62% 65% 71.5% 89% 85% 88% 100% 100% 100% 46% nF 80% 70% 71% 72% 100%
Release
IN 31 IN 34 IN 23
In 30 Min
MIN MIN MIN
Abbreviations: CMM, cellulose microcrystalline; PEG, polyethylene glycal; CMCNa, sodium carboxymethyl cellulose; PVP, Kollidon K30; SDS, sodium docecyl
sulfate; MgEs, magnesium stearate; NF, no fl ow ability.
Internal phase.
a