Pharmaceutical Manufacturing Handbook: Production and

1080 TABLET PRODUCTION SYSTEMS
In[1/(1-D rel)]
ω
2,5
2
1,5
1
0,5
0
–0,5
–1
0
0.04
0.02
0.00 0
0,2
0,4
Time (normalized)
0.72 0.90
1
0,6
0.74
0.84 0.72
d
0.72
2
0,8
(a)
(b)
Pressure (MPa)
FIGURE 19 ( a ) 3D data plot with fi tted plane twisted at t = t max and ( b ) 3D parameter plot
of ( � ) DCPD: dicalcium phosphate dihydrate, ( � ) spray - dried lactose, ( � ) MCC: microcrystalline
cellulose, ( ) theophylline monohydrate, and ( � ) HPMC: hydroxypropyl methylcellulose
for data gained with an eccentric tableting machine [47] .
0.88
1 0
0.89
0.000
50
0.005
100
Increasing ρ rein, max
0.010
e (MPa –1)
150
0.015
and ω (twisting angle, which indicates fast elastic decompression) can be derived
(Table 8 ).
The parameters of the fi tted plane (time plasticity d , pressure plasticity e , and
twisting angle ω ) were also exhibited in a 3D plot and this plot is called the 3D
parameter plot. This plot exhibits the compression behavior of the powder. It gives
a simple yet characteristic description of the tableting properties. An example is
given in Figure 19 b .