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Pharmaceutical Manufacturing Handbook: Production and

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650 NASAL DELIVERY OF PEPTIDE AND NONPEPTIDE DRUGS<br />

228. Aguilar , J. C. , Lobaina , Y. , Muzio , V. , Garcia , D. , Penton , E. , Iglesias , E. , Pichardo , D. ,<br />

Urquiza , D. , Rodeiguez , D. , Silva , D. , Petrovsky , N. , <strong>and</strong> Guillen , G. ( 2004 ), Development<br />

of a nasal vaccine for chronic hepatitis B infection that uses the ability of hepatitis B<br />

core antigen to stimulate a strong Th1 response against hepatitis B surface antigen ,<br />

Immnol. Cell. Biol. , 82 , 539 – 546 .<br />

229. Hordness , K. , Tynning , T. , Brown , T. A. , Haneberg , B. , <strong>and</strong> Jonsson , R. ( 1997 ), Nasal<br />

immunization with group B streptococci can induce high levels of specifi c IgA antibodies<br />

in cervicovaginal secretions of mice , Vaccine , 15 , 1244 – 1251 .<br />

230. Kurono , Y. , Yamamoto , M. , Fujihashi , K. , Kodama , S. , Suzuki , M. , Mogi , G. , McGhee ,<br />

J. R. , <strong>and</strong> Kiyono , H. ( 1991 ), Nasal immunization induces Haemophilis infl uenzae -<br />

specifi c Th1 <strong>and</strong> Th2 responses with mucosal IgA <strong>and</strong> systemic IgG antibodies for protective<br />

immunity , J. Infect. Dis. , 180 , 122 – 132 .<br />

231. Hagiwara , Y. , Komase , K. , Chen , Z. , Matsuo , K. , Suzuki , Y. , Aizawa , C. , Kurata , T. , <strong>and</strong><br />

Tamura , S. ( 1999 ), Mutants of cholera toxin as an effective <strong>and</strong> safe adjuvant for nasal<br />

infl uenza vaccine , Vaccine , 17 , 2918 – 2926 .<br />

232. Bastein , N. , Trudel , M. , <strong>and</strong> Simard , C. ( 1999 ), Complete protection of mice from respiratory<br />

syncytial virus infection following mucosal delivery of synthetic peptide vaccines ,<br />

Vaccine , 17 , 832 – 836 .

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