Pharmaceutical Manufacturing Handbook: Production and

718 AEROSOL DRUG DELIVERY
119. Lewis , D. A. , Ganderton , D. , Meakin , B. J. , and Brambilla , G. ( 2004 ), Theory and practice
with solution systems , in: Dalby , R. N. , Byron , P. R. , Peart , J. , Suman , J.D. , and Farr , S. J. ,
eds., Respiratory Drug Delivery IX , Davis Healthcare International , River Grove, IL ,
pp. 109 – 115 .
120. Polli , G. P. , Grim , W. M. , Bacher , F. A. , and Yunker , M. H. ( 1969 ), Infl uence of formulation
on aerosol particle size , J. Pharm. Sci. , 58 , 484 – 486 .
121. Stein , S. W. , and Myrdal , P. B. ( 2004 ), A theoretical and experimental analysis of formulation
and device parameters affecting solution MDI size distributions , J. Pharm. Sci. ,
93 , 2158 – 2175 .
122. Purewal , T. S. , and Grant , D. J. W. , Eds. ( 1998 ), Metered Dose Inhaler Technology , CRC
Press , Boca Raton .
123. Rogers , D. F. , and Ganderton , D. ( 1995 ), Determining equivalence of inhaled medications,
consensus statement from a workshop of the British association for lung research,
held at Royal Brompton National Heart & Lung Institute, London 24 June 1994 , Respir.
Med. , 89 , 253 – 261 .
124. Meakin , B. J. , Lewis , D. A. , Ganderton , D. , and Brambilla , G. ( 2000 ), Countering challenges
posed by mimicry of CFC performance using HFA systems , in: Dalby , R. N. ,
Byron , P. R. , Peart , J. , and Farr , S. J. , Eds., Respiratory Drug Delivery VII , Serentec ,
Raleigh, NC , pp. 99 – 107 .
125. Smyth , H. D. , and Leach , C. L. ( 2005 ), Alternative propellant aerosol delivery systems ,
Crit. Rev. Ther. Drug Carrier Syst. , 22 , 493 – 534 .
126. Pritchard , J. N. , and Genova , P. ( 2006 ), Adapting the pMDI to deliver novel drugs: Insulin
and beyond , in: Dalby , R. N. , Byron , P. R. , Peart , J. , Suman , J. D. , and Farr , S. J. , Eds.,
Respiratory Drug Delivery , 2006, Davis Healthcare International , River Grove, IL ,
pp. 133 – 141 .
127. Jannick , P. ( 2006 ), CFC phase - out scenarios of pressurized metered dose inhalers:
Current status , in: Dalby , R. N. , Byron , P. R. , Peart , J. , Suman , J. D. , and Farr , S. J. , Eds.,
Respiratory Drug Delivery , 2006, Davis Healthcare International , River Grove, IL ,
pp. 789 – 792 .
128. Anonymous ( 2006 ), A levalbuterol metered - dose inhaler (xopenex HFA) for asthma ,
Med. Lett. Drugs Ther. , 48, 21 – 22 , 24 .
129. Byron , P. R. ( 1994 ), Dosing reproducibility from experimental albuterol suspension
metered - dose inhalers , Pharm. Res. , 11 , 580 – 584 .
130. Tansey , I. ( 1997 ), The technical transition to CFC - free inhalers , Br. J. Clin. Pract. Suppl. ,
89 , 22 – 27 .
131. Stefely , J. D. , Duan , D. C. , Myrdal , P. B. , Ross , D. L. , Schultz , D. W. , and Leach , C. L.
( 2000 ), Design and utility of a novel class of biocompatible excipients for HFA - based
MDIs , in: Dalby , R. N. , Byron , P. R. , Peart , J. , and Farr , S. J. , Eds., Respiratory Drug
Delivery VII , Serentec Press , Raleigh, NC , pp. 83 – 90 .
132. Stein , S. W. , and Myrdal , P. B. ( 2006 ), The relative infl uence of atomization and evaporation
on metered dose inhaler drug delivery effi ciency , Aerosol Sci. Tech. , 40 , 335 – 347 .
133. Leach , C. L. , Davidson , P. J. , and Boudreau , R. J. ( 1998 ), Improved airway targeting
with the CFC - free HFA - beclomethasone metered - dose inhaler compared with CFC -
beclomethasone , Eur. Respir. J. , 12 , 1346 – 1353 .
134. Seale , J. P. , and Harrison , L. I. ( 1998 ), Effect of changing the fi ne particle mass of inhaled
beclomethasone dipropionate on intrapulmonary deposition and pharmacokinetics ,
Respir. Med. , 92 ( Suppl. A ), 9 – 15 .
135. Berry , J. , Kline , L. C. , Hart , J. L. , and Sequeira , J. ( 2003 ), Infl uence of the storage orientation
on the aerodynamic particle size of a suspension metered dose inhaler containing
propellant HFA - 227 , Drug Dev. Ind. Pharm. , 29 , 631 – 639 .