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Pharmaceutical Manufacturing Handbook: Production and

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428 BIODEGRADABLE POLYMER-BASED MICROSPHERES<br />

17. Kostanski , J. W. , Thanoo , B. C. , <strong>and</strong> Deluca , P. P. ( 2000 ), Preparation, characterization<br />

<strong>and</strong> in vitro evaluation of 1 - <strong>and</strong> 4 - month controlled release ornitide PLA <strong>and</strong> PLGA<br />

microspheres , Pharm. Dev. Technol ., 5 , 585 – 596 .<br />

18. King , T. W. , <strong>and</strong> Patrick , Jr ., C. W. ( 2000 ), Development <strong>and</strong> in vitro characterization of<br />

vascular endothelial growth factor (VEGF) loaded poly( dl - lactic - co - glycolicacid)/<br />

poly(ethylene glycol) microspheres using a solid encapsulation/single emulsion/solvent<br />

extraction technique , J. Biomed. Mater. Res ., 51 , 383 – 390 .<br />

19. Zhu , K. J. , Jiang , H. L. , Du , X. Y. , Wang , J. , Xu , W. X. , <strong>and</strong> Liu , S. F. ( 2001 ), Preparation<br />

<strong>and</strong> characterization of hCG - loaded polylactide or poly(lactide -co - glycolide) microspheres<br />

using a modifi ed water - in - oil - in - water (w/o/w) emulsion solvent evaporation<br />

technique , J. Microencapsul ., 18 , 247 – 260 .<br />

20. Prabhu , S. , Sullivan , J. L. , <strong>and</strong> Betageri , G. V. ( 2002 ), Comparative assessment of in vitro<br />

release kinetics of calcitonin polypeptide from biodegradable microspheres , Drug Deliv .,<br />

9 , 195 – 198 .<br />

21. Oldham , J. B. , Lu , L. , Zhu , X. , Porter , B. D. , Hefferan , T. E. , Larson . D. R. , Currier , B. L. ,<br />

Mikos , A. G. , <strong>and</strong> Yaszemski , M. J. ( 2000 ), Biological activity of rhBMP - 2 released from<br />

PLGA microspheres , J. Biomech. Eng ., 122 , 289 – 292 .<br />

22. Woo , B. H. , Fink , B. F. , Page , R. , Schrier , J. A. , Jo , Y. W. , Jiang , G. , DeLuca , M. Vasconez ,<br />

H. C. , <strong>and</strong> DeLuca , P. P. ( 2001 ), Enhancement of bone growth by sustained delivery of<br />

recombinant human bone morphogenetic protein - 2 in a polymeric matrix , Pharm. Res .,<br />

18 , 1747 – 1753 .<br />

23. Weber , F. E. , Eyrich , G. , Gratz , K. W. , Maly , F. E. , <strong>and</strong> Sailer , H. F. ( 2002 ), Slow <strong>and</strong> continuous<br />

application of human recombinant bone morphogenetic protein via biodegradable<br />

poly(lactide -co - glycolide) foamspheres , Int. J. of Oral Maxillofacial Surg ., 31 ,<br />

60 – 65 .<br />

24. Bordem , M. D. , Khan , Y. , Attawia , M. , <strong>and</strong> Laurencin , C. T. ( 2001 ), Tissue engineered<br />

microsphere - based matrices for bone repair: Design, evaluation <strong>and</strong> optimisation , Biomaterials<br />

, 23 , 551 – 559 .<br />

25. Lu , L. , Stamatas , G. N. , <strong>and</strong> Mikos , A. G. ( 2000 ), Controlled release of transforming<br />

growth factor beta 1 from biodegradable polymer microparticles , J. Biomed. Mater. Res .,<br />

50 , 440 – 451 .<br />

26. Fu , K. , Griebenow , K. , Hsieh , L. , Klibanov , A. M. , <strong>and</strong> Langer , R. ( 1999 ), FTIR characterization<br />

of the secondary structure of proteins encapsulated within PLGA microspheres<br />

, J. Controlled Release , 58 , 357 – 366 .<br />

27. Bezemer , J. M. , Radersma , R. , Grijpma , D. W. , Dijkstra , P. J. , van Blitterswijk , C. A. , <strong>and</strong><br />

Feijen , J. ( 2000 ), Microspheres for protein delivery prepared from amphiphilic multiblock<br />

copolymers. I. Infl uence of preparation techniques on particle characteristics <strong>and</strong><br />

protein delivery , J. Controlled Release , 67 , 233 – 248 .<br />

28. Rosas , J. E. , Pedraz , J. L. , Hern<strong>and</strong>ez , R. M. , Gascon , A. R. , Igartua , M. , Guzman , F. ,<br />

Rodrignuez , R. , Cortes , J. , <strong>and</strong> Patarroyo , M. E. ( 2002 ), Remarkably high antibody levels<br />

<strong>and</strong> protection against P. falciparum malaria in Aotus monkey after a single immunization<br />

of SPf66 encapsulated in PLGA microspheres , Vaccine , 20 , 1707 – 1710 .<br />

29. Boehm , G. , Peyre , M. , Sesardie , D. , Huskisson , R. J. , Mawas , F. , Douglas , A. , Xing , D. ,<br />

Merkle , H. P. , G<strong>and</strong>er , B. , <strong>and</strong> Johansen , P. ( 2002 ), On technological <strong>and</strong> immunological<br />

benefi ts of multivalent single - injection microspheres vaccines . Pharm. Res ., 19 ,<br />

1330 – 1336 .<br />

30. Sturesson , C. , Artursson , P. , Ghaderi , R. , Johansen , K. , Mirazimi , A. , Uhnoo , I. , Svensson ,<br />

L. , Alberstsson , A. C. , <strong>and</strong> Carlfors , J. ( 1999 ), Encapsulation of rotavirus into poly(lactide -<br />

co - glycolide) microspheres , J. Controlled Release , 59 , 377 – 389 .

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