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Pharmaceutical Manufacturing Handbook: Production and

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864 VAGINAL DRUG DELIVERY<br />

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17 beta - oestradiol - releasing vaginal ring in the treatment of postmenopausal complaints ,<br />

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Estradiol - progesterone interaction during the preparation of vaginal rings , J. Pharm.<br />

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129. Malcolm , K. , Woolfson , D. , Russell , J. , Tallon , P. , McAuley , L. , <strong>and</strong> Craig , D. ( 2003 ), Infl uence<br />

of silicone elastomer solubility <strong>and</strong> diffusivity on the in vitro release of drugs from<br />

intravaginal rings , J. Controlled Release , 90 , 217 – 225 .<br />

130. Lee , C. H. , Bhatt , P. P. , <strong>and</strong> Chien , Y. W. ( 1997 ), Effect of excipient on drug release <strong>and</strong><br />

permeation from silicone - based barrier devices , Int. J. Pharm. , 43 , 283 – 290 .<br />

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sulfonate (PSS), a novel contraceptive antimicrobial agent , Pharm. Res. , 22 ,<br />

584 – 595 .<br />

132. Yoo , J. W. , Dharmala , K. , <strong>and</strong> Lee , C. H. ( 2006 ), The physicodynamic properties of mucoadhesive<br />

polymeric fi lms developed as female controlled drug delivery system , Int. J.<br />

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phase I comparative study of contraceptive vaginal fi lms containing benzalkonium chloride<br />

<strong>and</strong> nonoxynol - 9. Postcoital testing <strong>and</strong> colposcopy , Contraception , 56 , 89 – 96 .<br />

134. Chien , Y. W. , Oppermann , J. , Nicolova , B. , <strong>and</strong> Lambert , H. J. ( 1982 ), Medicated tampons:<br />

Intravaginal sustained administration of metronidazole <strong>and</strong> in vitro – in vivo relationships<br />

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pH - buffering tampon in preserving the acidic vaginal pH during menstruation , Int. J.<br />

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136. Bernstein , G. S. ( 1974 ), Conventional methods of contraception: Condom, diaphragm,<br />

<strong>and</strong> vaginal foam , Clin. Obstet. Gynecol. , 17 , 21 – 33 .<br />

137. Youssef , H. , Crofton , V. A. , Smith , S. C. , <strong>and</strong> Siemens , A. J. ( 1987 ), A clinical trial of Neo<br />

Sampoon vaginal tablets <strong>and</strong> Emko foam in Alex<strong>and</strong>ria, Egypt , Contraception , 35 ,<br />

101 – 110 .<br />

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Methods , Prometheus Books , Buffalo, NY .<br />

139. Smith , C. B. , Noble , V. , Bensch , R. , Ahlin , P. A. , Jacobson , J. A. , <strong>and</strong> Latham , R. H. ( 1982 ),<br />

Bacterial fl ora of the vagina during the menstrual cycle: Findings in users of tampons,<br />

napkins, <strong>and</strong> sea sponges , Ann. Intern. Med. , 96 , 948 – 951 .<br />

140. Kafka , D. , <strong>and</strong> Gold , R. B. ( 1983 ), Food <strong>and</strong> Drug Administration approves vaginal<br />

sponge , Fam. Plann. Perspect. , 15 , 146 – 148 .

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