Pharmaceutical Manufacturing Handbook: Production and

722 AEROSOL DRUG DELIVERY
189. Sham , J. O. , Zhang , Y. , Finlay , W. H. , Roa , W. H. , and Lobenberg , R. ( 2004 ), Formulation
and characterization of spray - dried powders containing nanoparticles for aerosol delivery
to the lung , Int. J. Pharm. , 269 , 457 – 467 .
190. Begat , P. , Morton , D. A. , Staniforth , J. N. , and Price , R. ( 2004 ), The cohesive - adhesive
balances in dry powder inhaler formulations I: Direct quantifi cation by atomic force
microscopy , Pharm. Res. , 21 , 1591 – 1597 .
191. Davies , M. , Brindley , A. , Chen , X. , et al. ( 2005 ), Characterization of drug particle surface
energetics and Young ’ s modulus by atomic force microscopy and inverse gas chromatography
, Pharm. Res. , 22 , 1158 – 1166 .
192. Larhrib , H. , Zeng , X. M. , Martin , G. P. , Marriott , C. , and Pritchard , J. ( 1999 ), The use of
different grades of lactose as a carrier for aerosolised salbutamol sulphate , Int. J. Pharm. ,
191 , 1 – 14 .
193. Zeng , X. M. , Pandhal , K. H. , and Martin , G. P. ( 2000 ), The infl uence of lactose carrier on
the content homogeneity and dispersibility of beclomethasone dipropionate from dry
powder aerosols , Int. J. Pharm. , 197 , 41 – 52 .
194. Lucas , P. , Anderson , K. , and Staniforth , J. N. ( 1998 ), Protein deposition from dry powder
inhalers: Fine particle multiplets as performance modifi ers , Pharm. Res. , 15 , 562 – 569 .
195. Begat , P. , Morton , D. A. , Staniforth , J. N. , and Price , R. ( 2004 ), The cohesive - adhesive
balances in dry powder inhaler formulations II: Infl uence on fi ne particle delivery characteristics
, Pharm. Res. , 21 , 1826 – 1833 .
196. Jones , M. , and Price , R. ( 2006 ), The infl uence of fi ne excipient particles on the performance
of carrier - based dry powder inhalation formulations , Pharm. Res. , 23 ,
1665 – 1674 .
197. Ming Zeng , X. , Martin , G. P. , Marriott , C. , and Pritchard , J. ( 2001 ), The use of lactose
recrystallised from carbopol gels as a carrier for aerosolised salbutamol sulphate , Eur.
J. Pharm. Biopharm. , 51 , 55 – 62 .
198. Flament , M. P. , Leterme , P. , and Gayot , A. ( 2004 ), The infl uence of carrier roughness on
adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from
dry powder inhalers , Int. J. Pharm. , 275 , 201 – 209 .
199. Zeng , X. M. , Martin , G. P. , Marriott , C. , and Pritchard , J. ( 2001 ), Lactose as a carrier in
dry powder formulations: The infl uence of surface characteristics on drug delivery ,
J. Pharm. Sci. , 90 , 1424 – 1434 .
200. El - Sabawi , D. , Price , R. , Edge , S. , and Young , P. M. ( 2006 ), Novel temperature controlled
surface dissolution of excipient particles for carrier based dry powder inhaler formulations
, Drug Dev. Ind. Pharm. , 32 , 243 – 251 .
201. Steckel , H. , and Bolzen , N. ( 2004 ), Alternative sugars as potential carriers for dry powder
inhalations , Int. J. Pharm. , 270 , 297 – 306 .
202. Lucas , P. , Anderson , K. , Potter , U. J. , and Staniforth , J. N. ( 1999 ), Enhancement of small
particle size dry powder aerosol formulations using an ultra low density additive , Pharm.
Res. , 16 , 1643 – 1647 .
203. Hindle , M. , Jashnani , R. N. , and Byron , P. R. ( 1994 ), Dose emissions from marketed dry
powder inhalers: Infl uence of fl ow, volume and environment , in: Byron , P. R. , Dalby , R.
N. , and Farr , S. J. , Eds., Respiratory Drug Delivery IV , Interpharm , Buffalo Grove, IL ,
pp. 137 – 142 .
204. Borgstrom , L. , Asking , L. , and Lipniunas , P. ( 2005 ), An in vivo and in vitro comparison
of two powder inhalers following storage at hot/humid conditions , J. Aerosol Med. , 18 ,
304 – 310 .
205. Price , R. , Young , P. M. , Edge , S. , and Staniforth , J. N. ( 2002 ), The infl uence of relative
humidity on particulate interactions in carrier - based dry powder inhaler formulations ,
Int. J. Pharm. , 246 , 47 – 59 .