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Pharmaceutical Manufacturing Handbook: Production and
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SECTION 7<br />
ROLE OF NANOTECHNOLOGY
1222 ORAL EXTENDED-RELEASE FORMULATIONS 142. Takka , S. , Rajbh<strong>and</strong>ari , S. , <strong>and</strong> Sakr , A. ( 2001 ), Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets , Eur. J. Pharm. Biopharm. , 52 , 75 – 82 . 143. Nie , S. , Pan , W. , Li , X. , <strong>and</strong> Wu , X. ( 2004 ), The effect of citric acid added to hydroxypropyl methylcellulose (HPMC) matrix tablets on the release profi le of vinpocetine , Drug Dev. Ind. Pharm. , 30 , 627 – 635 . 144. Varma , M. V. S. , Kaushal , A. M. , <strong>and</strong> Garg , S. ( 2005 ), Infl uence of micro - environmental pH on the gel layer behavior <strong>and</strong> release of a basic drug from various hydrophilic matrices , J. Controlled Release , 103 , 499 – 510 . 145. Qiu , Y. , <strong>and</strong> Park , K. ( 2001 ), Environment - sensitive hydrogels for drug delivery , Adv. Drug Deliv. Rev. , 53 , 321 – 339 . 146. Bromberg , L. ( 2005 ), Intelligent hydrogels for the oral delivery of chemotherapeutics , Exp. Opin. Drug Deliv. , 2 , 1003 – 1013 . 147. Rowe , C. W. , Wang , C - C. , <strong>and</strong> Monkhouse , D. C. ( 2003 ), TheriForm technology , Drugs Pharm. Sci. , 126 , 77 – 87 . 148. Lee , K - J. , Kang , A. , Delfi no , J. J. , West , T. G. , Chetty , D. , Monkhouse , D. C. , <strong>and</strong> Yoo , J. ( 2003 ), Evaluation of critical formulation factors in the development of a rapidly dispersing captopril oral dosage form , Drug Dev. Ind. Pharm. , 29 , 967 – 979 . 149. Rocca , J. G. , <strong>and</strong> Park , K. ( 2004 ), Oral drug delivery: Prospects & challenges , Drug Deliv. Technol. , 4 , 52 – 54 , 57 .
SECTION 7 ROLE OF NANOTECHNOLOGY
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PHARMACEUTICAL MANUFACTURING HANDBO
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PHARMACEUTICAL MANUFACTURING HANDBO
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CONTRIBUTORS Susanna Abrahms é n -
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CONTRIBUTORS vii Eddy Castellanos G
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CONTENTS PREFACE xiii SECTION 1 MAN
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CONTENTS xi 5.11 Transdermal Drug D
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SECTION 1 MANUFACTURING SPECIALTIES
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4 BIOTECHNOLOGY-DERIVED DRUG PRODUC
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6 BIOTECHNOLOGY-DERIVED DRUG PRODUC
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8 BIOTECHNOLOGY-DERIVED DRUG PRODUC
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10 BIOTECHNOLOGY-DERIVED DRUG PRODU
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12 BIOTECHNOLOGY-DERIVED DRUG PRODU
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14 BIOTECHNOLOGY-DERIVED DRUG PRODU
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16 BIOTECHNOLOGY-DERIVED DRUG PRODU
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18 BIOTECHNOLOGY-DERIVED DRUG PRODU
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20 BIOTECHNOLOGY-DERIVED DRUG PRODU
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22 BIOTECHNOLOGY-DERIVED DRUG PRODU
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24 BIOTECHNOLOGY-DERIVED DRUG PRODU
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26 BIOTECHNOLOGY-DERIVED DRUG PRODU
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28 BIOTECHNOLOGY-DERIVED DRUG PRODU
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30 BIOTECHNOLOGY-DERIVED DRUG PRODU
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32 BIOTECHNOLOGY-DERIVED DRUG PRODU
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34 REGULATORY CONSIDERATIONS IN APP
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36 REGULATORY CONSIDERATIONS IN APP
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38 REGULATORY CONSIDERATIONS IN APP
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40 REGULATORY CONSIDERATIONS IN APP
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42 REGULATORY CONSIDERATIONS IN APP
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44 REGULATORY CONSIDERATIONS IN APP
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46 REGULATORY CONSIDERATIONS IN APP
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48 REGULATORY CONSIDERATIONS IN APP
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50 REGULATORY CONSIDERATIONS IN APP
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52 REGULATORY CONSIDERATIONS IN APP
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54 REGULATORY CONSIDERATIONS IN APP
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56 REGULATORY CONSIDERATIONS IN APP
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1.3 RADIOPHARMACEUTICAL MANUFACTURI
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The terms tracer, radiotracer , and
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number of atoms that disintegrate d
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images that can also give quantitat
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PRODUCT DEVELOPMENT 67 Product Stab
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MANUFACTURING ASPECTS 69 stations s
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In general, the manufacturing of mo
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MANUFACTURING ASPECTS 73 Production
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PRODUCT MANUFACTURING 75 tainer. Th
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PRODUCT MANUFACTURING 77 practical
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PRODUCT MANUFACTURING 79 these radi
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PRODUCT MANUFACTURING 81 Most of th
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PRODUCT MANUFACTURING 83 PET Radiop
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PRODUCT MANUFACTURING 85 FIGURE 5 S
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PRODUCT MANUFACTURING 87 tions in t
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QUALITY CONSIDERATIONS 89 regulatio
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L1 L2 TC-MDP + Hydr. Tc TC-MDP + Tc
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EXTEMPORANEOUS PREPARATION OF RADIO
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Independent of which regulation app
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SECTION 2 ASEPTIC PROCESSING
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100 STERILE PRODUCT MANUFACTURING 2
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102 STERILE PRODUCT MANUFACTURING A
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104 STERILE PRODUCT MANUFACTURING T
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106 STERILE PRODUCT MANUFACTURING E
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108 STERILE PRODUCT MANUFACTURING I
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110 STERILE PRODUCT MANUFACTURING 2
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112 STERILE PRODUCT MANUFACTURING c
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114 STERILE PRODUCT MANUFACTURING 2
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116 STERILE PRODUCT MANUFACTURING 2
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118 STERILE PRODUCT MANUFACTURING i
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120 STERILE PRODUCT MANUFACTURING o
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122 STERILE PRODUCT MANUFACTURING a
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124 STERILE PRODUCT MANUFACTURING a
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126 STERILE PRODUCT MANUFACTURING e
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128 STERILE PRODUCT MANUFACTURING A
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130 STERILE PRODUCT MANUFACTURING 2
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132 STERILE PRODUCT MANUFACTURING p
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134 STERILE PRODUCT MANUFACTURING 2
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SECTION 3 FACILITY
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140 EFFECT OF SCALE-UP ON OPERATION
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142 EFFECT OF SCALE-UP ON OPERATION
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144 EFFECT OF SCALE-UP ON OPERATION
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146 EFFECT OF SCALE-UP ON OPERATION
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148 EFFECT OF SCALE-UP ON OPERATION
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150 EFFECT OF SCALE-UP ON OPERATION
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152 EFFECT OF SCALE-UP ON OPERATION
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154 EFFECT OF SCALE-UP ON OPERATION
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156 EFFECT OF SCALE-UP ON OPERATION
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158 EFFECT OF SCALE-UP ON OPERATION
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160 PACKAGING AND LABELING 3.2.1 3.
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162 PACKAGING AND LABELING signifi
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164 PACKAGING AND LABELING Although
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166 PACKAGING AND LABELING componen
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168 PACKAGING AND LABELING sions. T
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170 PACKAGING AND LABELING TABLE 1
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172 PACKAGING AND LABELING the stab
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174 PACKAGING AND LABELING and accu
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176 PACKAGING AND LABELING The safe
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178 PACKAGING AND LABELING If the p
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180 PACKAGING AND LABELING exposure
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182 PACKAGING AND LABELING In many
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184 PACKAGING AND LABELING Nonpharm
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186 PACKAGING AND LABELING In 1906,
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188 PACKAGING AND LABELING A medica
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190 PACKAGING AND LABELING The inst
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192 PACKAGING AND LABELING the poun
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194 PACKAGING AND LABELING • (4)
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196 PACKAGING AND LABELING In the c
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198 PACKAGING AND LABELING • Inte
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200 PACKAGING AND LABELING 27. U.S.
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202 CLEAN-FACILITY DESIGN, CONSTRUC
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204 CLEAN-FACILITY DESIGN, CONSTRUC
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206 CLEAN-FACILITY DESIGN, CONSTRUC
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208 CLEAN-FACILITY DESIGN, CONSTRUC
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210 CLEAN-FACILITY DESIGN, CONSTRUC
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212 CLEAN-FACILITY DESIGN, CONSTRUC
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214 CLEAN-FACILITY DESIGN, CONSTRUC
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216 CLEAN-FACILITY DESIGN, CONSTRUC
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218 CLEAN-FACILITY DESIGN, CONSTRUC
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220 CLEAN-FACILITY DESIGN, CONSTRUC
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222 CLEAN-FACILITY DESIGN, CONSTRUC
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224 CLEAN-FACILITY DESIGN, CONSTRUC
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226 CLEAN-FACILITY DESIGN, CONSTRUC
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228 CLEAN-FACILITY DESIGN, CONSTRUC
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230 CLEAN-FACILITY DESIGN, CONSTRUC
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232 CLEAN-FACILITY DESIGN, CONSTRUC
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4.1 SOLID DOSAGE FORMS Barbara R. C
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TABLE 2 Types of Solid Dosage Form
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(GI) tract or for systemic effects.
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EXCIPIENTS IN SOLID DOSE FORMULATIO
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EXCIPIENTS IN SOLID DOSE FORMULATIO
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HARD AND SOFT GELATIN CAPSULES 245
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HARD AND SOFT GELATIN CAPSULES 247
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HARD AND SOFT GELATIN CAPSULES 249
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participants from the FDA, industry
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in the mouth. Compressed lozenges (
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ittle fi lm, have no unpleasant tas
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CHEWING GUMS 257 4.1.10.2 Manufactu
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already dissolved in the saliva pri
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ORALLY DISINTEGRATING TABLETS 261 a
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tions. Some buccal formulations hav
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REFERENCES 265 32. Habib , W. , Kha
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268 SEMISOLID DOSAGES: OINTMENTS, C
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270 SEMISOLID DOSAGES: OINTMENTS, C
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272 SEMISOLID DOSAGES: OINTMENTS, C
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274 SEMISOLID DOSAGES: OINTMENTS, C
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276 SEMISOLID DOSAGES: OINTMENTS, C
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278 SEMISOLID DOSAGES: OINTMENTS, C
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280 SEMISOLID DOSAGES: OINTMENTS, C
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282 SEMISOLID DOSAGES: OINTMENTS, C
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284 SEMISOLID DOSAGES: OINTMENTS, C
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286 SEMISOLID DOSAGES: OINTMENTS, C
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288 SEMISOLID DOSAGES: OINTMENTS, C
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290 SEMISOLID DOSAGES: OINTMENTS, C
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292 SEMISOLID DOSAGES: OINTMENTS, C
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294 SEMISOLID DOSAGES: OINTMENTS, C
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296 SEMISOLID DOSAGES: OINTMENTS, C
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298 SEMISOLID DOSAGES: OINTMENTS, C
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300 SEMISOLID DOSAGES: OINTMENTS, C
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302 SEMISOLID DOSAGES: OINTMENTS, C
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304 SEMISOLID DOSAGES: OINTMENTS, C
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306 SEMISOLID DOSAGES: OINTMENTS, C
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308 SEMISOLID DOSAGES: OINTMENTS, C
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310 SEMISOLID DOSAGES: OINTMENTS, C
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312 SEMISOLID DOSAGES: OINTMENTS, C
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314 LIQUID DOSAGE FORMS 4.3.1 INTRO
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316 LIQUID DOSAGE FORMS 4.3.2 GENER
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318 LIQUID DOSAGE FORMS design, bui
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320 LIQUID DOSAGE FORMS tions with
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322 LIQUID DOSAGE FORMS Dosing Pump
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324 LIQUID DOSAGE FORMS However, th
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326 LIQUID DOSAGE FORMS Location of
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328 LIQUID DOSAGE FORMS Solid drugs
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330 LIQUID DOSAGE FORMS TABLE 3 Emu
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332 LIQUID DOSAGE FORMS Temperature
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334 LIQUID DOSAGE FORMS for viscosi
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336 LIQUID DOSAGE FORMS spectrum, s
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338 LIQUID DOSAGE FORMS Product Spe
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340 LIQUID DOSAGE FORMS Liquid, Ext
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342 LIQUID DOSAGE FORMS 7. Kourouna
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344 LIQUID DOSAGE FORMS 46. Miller
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5.1 CONTROLLED - RELEASE DOSAGE FOR
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CONTROLLED-RELEASE DRUG DELIVERY SY
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CONTROLLED-RELEASE FORMULATIONS 351
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dosage forms [12] . For example, or
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Degradation Liver Hydrolytic Enzyma
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CONTROLLED-RELEASE ORAL DOSAGE FORM
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DESIGN AND FABRICATION OF CONTROLLE
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DESIGN AND FABRICATION OF CONTROLLE
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DESIGN AND FABRICATION OF CONTROLLE
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DESIGN AND FABRICATION OF CONTROLLE
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TECHNOLOGIES FOR DEVELOPING TRANSDE
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TECHNOLOGIES FOR DEVELOPING TRANSDE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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REFERENCES 387 16. Anal , A. K. ( 2
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REFERENCES 389 57. M ü ller , R. H
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REFERENCES 391 96. Sungthongjeen ,
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5.2 PROGRESS IN DESIGN OF BIODEGRAD
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INTRODUCTION 395 sequences. In addi
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TABLE 2 Injectable Peptide/Proteins
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PEPTIDE/PROTEIN-LOADED MICROSPHERE
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PEPTIDE/PROTEIN-LOADED MICROSPHERE
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PEPTIDE/PROTEIN-LOADED MICROSPHERE
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ANALYTICAL CHARACTERIZATION 405 imm
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IMMUNE SYSTEM INTERACTION WITH INJE
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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PEPTIDE/PROTEIN ENCAPSULATED INTO B
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PEPTIDE/PROTEIN ENCAPSULATED INTO B
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PEPTIDE/PROTEIN ENCAPSULATED INTO B
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PEPTIDE/PROTEIN ENCAPSULATED INTO B
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REFERENCES 427 novel ways to reduce
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REFERENCES 429 31. Morlock , M. , K
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REFERENCES 431 63. Lam , X. M. , Du
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REFERENCES 433 95. van de Weert , M
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REFERENCES 435 130. Bilati , U. , A
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REFERENCES 437 166. Means , G. E. ,
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REFERENCES 439 bic poly(lactide -co
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REFERENCES 441 237. Singh , M. , Li
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444 LIPOSOMES AND DRUG DELIVERY (sm
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446 LIPOSOMES AND DRUG DELIVERY Con
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448 LIPOSOMES AND DRUG DELIVERY and
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450 LIPOSOMES AND DRUG DELIVERY tec
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452 LIPOSOMES AND DRUG DELIVERY 250
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454 LIPOSOMES AND DRUG DELIVERY a s
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456 LIPOSOMES AND DRUG DELIVERY For
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458 LIPOSOMES AND DRUG DELIVERY con
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460 LIPOSOMES AND DRUG DELIVERY The
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462 LIPOSOMES AND DRUG DELIVERY in
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464 LIPOSOMES AND DRUG DELIVERY c a
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466 LIPOSOMES AND DRUG DELIVERY Eve
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468 LIPOSOMES AND DRUG DELIVERY inc
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470 LIPOSOMES AND DRUG DELIVERY wit
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472 LIPOSOMES AND DRUG DELIVERY i.v
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474 LIPOSOMES AND DRUG DELIVERY for
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476 LIPOSOMES AND DRUG DELIVERY bet
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478 LIPOSOMES AND DRUG DELIVERY cli
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480 LIPOSOMES AND DRUG DELIVERY lea
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482 LIPOSOMES AND DRUG DELIVERY Vag
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484 LIPOSOMES AND DRUG DELIVERY TAB
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486 LIPOSOMES AND DRUG DELIVERY thr
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488 LIPOSOMES AND DRUG DELIVERY TAB
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490 LIPOSOMES AND DRUG DELIVERY tar
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492 LIPOSOMES AND DRUG DELIVERY tha
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494 LIPOSOMES AND DRUG DELIVERY wit
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496 LIPOSOMES AND DRUG DELIVERY Pul
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498 LIPOSOMES AND DRUG DELIVERY whi
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500 LIPOSOMES AND DRUG DELIVERY Inc
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502 LIPOSOMES AND DRUG DELIVERY Per
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504 LIPOSOMES AND DRUG DELIVERY can
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506 LIPOSOMES AND DRUG DELIVERY Tum
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508 LIPOSOMES AND DRUG DELIVERY 25.
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510 LIPOSOMES AND DRUG DELIVERY 60.
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512 LIPOSOMES AND DRUG DELIVERY 97.
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514 LIPOSOMES AND DRUG DELIVERY 136
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516 LIPOSOMES AND DRUG DELIVERY 170
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518 LIPOSOMES AND DRUG DELIVERY 202
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520 LIPOSOMES AND DRUG DELIVERY 237
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522 LIPOSOMES AND DRUG DELIVERY 271
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524 LIPOSOMES AND DRUG DELIVERY 310
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526 LIPOSOMES AND DRUG DELIVERY 346
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528 LIPOSOMES AND DRUG DELIVERY 378
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530 LIPOSOMES AND DRUG DELIVERY 408
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532 LIPOSOMES AND DRUG DELIVERY 437
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5.4 BIODEGRADABLE NANOPARTICLES Sud
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NATURAL BIODEGRADABLE POLYMERIC NAN
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NATURAL BIODEGRADABLE POLYMERIC NAN
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NATURAL BIODEGRADABLE POLYMERIC NAN
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and drug loading of gliadin nanopar
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SYNTHETIC BIODEGRADABLE POLYMERIC N
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APPLICATIONS OF BIODEGRADABLE NANOP
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PHYSICOCHEMICAL CHARACTERIZATION OF
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TARGETING NANOPARTICLES BY SURFACE
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5.4.9 CONCLUSIONS Biodegradable nan
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REFERENCES 555 of a model protein (
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REFERENCES 557 65. Kaul , G. , and
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REFERENCES 559 99. Carino , G. P. ,
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REFERENCES 561 133. Na , K. , Lee ,
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REFERENCES 563 168. Freitas , C. ,
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5.5 RECOMBINANT SACCHAROMYCES CEREV
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Potential Medical Applications of B
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BIODRUG CONCEPT USING YEAST AS VECT
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BIODRUG CONCEPT USING YEAST AS VECT
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Cumulative ileal delivery of viable
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tine [30] . No signal was detectabl
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ORAL FORMULATION OF RECOMBINANT YEA
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Cumulative ileal delivery of viable
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ORAL FORMULATION OF RECOMBINANT YEA
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Viable yeasts released (% of initia
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Steidler et al. [47] have already d
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REFERENCES 587 23. Steidler , L. (
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REFERENCES 589 nant yeasts as novel
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5.6 NASAL DELIVERY OF PEPTIDE AND N
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fi rst - pass metabolism and gut -
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[6] . The nasal blood vessels can b
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FACTORS INFLUENCING NASAL DRUG ABSO
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5.6.3.6 Type of Delivery Device FAC
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FACTORS INFLUENCING NASAL DRUG ABSO
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FIGURE 4 ( a ) Optinose multidose l
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Dogs, sheep, and monkeys can be kep
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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in solutions containing different c
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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Morphine plasma concentration (nmol
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Concentration (μg/L) 1000 100 10 1
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NASAL DELIVERY OF NONPEPTIDE MOLECU
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NASAL DELIVERY OF NONPEPTIDE MOLECU
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OPTION FOR DELIVERY OF DRUGS TO CEN
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pseudostratifi ed epithelium compri
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NASAL DELIVERY OF VACCINES 635 Howe
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TABLE 5 Continued Delivery System/A
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REFERENCES 639 23. Hardy , J. G. ,
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REFERENCES 641 60. Collens , W. S.
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REFERENCES 643 97. Eden , S. ( 1979
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REFERENCES 645 comparison with oral
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REFERENCES 647 172. Sakane , T. , A
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REFERENCES 649 213. McCluskie , M.
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5.7 NASAL POWDER DRUG DELIVERY Jele
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NASAL DRY POWDER FORMULATIONS 653 t
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POLYMERS IN NASAL POWDER DELIVERY S
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POLYMERS IN NASAL POWDER DELIVERY S
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MICROSPHERES AS NASAL DRUG DELIVERY
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MICROSPHERES AS NASAL DRUG DELIVERY
- Page 679 and 680:
MICROSPHERES AS NASAL DRUG DELIVERY
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MICROSPHERES AS NASAL DRUG DELIVERY
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TOXICOLOGICAL CONSIDERATIONS 667 et
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Summary of Research Work on Nasal D
- Page 687 and 688:
Powder Formulation Preparation Meth
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Powder Formulation Preparation Meth
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REFERENCES 675 19. Van der Lubben ,
- Page 693 and 694:
REFERENCES 677 54. Witschi , C. , a
- Page 695 and 696:
REFERENCES 679 91. Varshosaz , J. ,
- Page 697:
REFERENCES 681 126. Jorissen , M. ,
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684 AEROSOL DRUG DELIVERY 5.8.8 5.8
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686 AEROSOL DRUG DELIVERY other sig
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688 AEROSOL DRUG DELIVERY are a num
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690 AEROSOL DRUG DELIVERY 5.8.5 MET
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692 AEROSOL DRUG DELIVERY TABLE 1 S
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694 AEROSOL DRUG DELIVERY valve siz
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696 AEROSOL DRUG DELIVERY Ferrule U
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698 AEROSOL DRUG DELIVERY 5.8.5.6 A
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700 AEROSOL DRUG DELIVERY 5.8.5.10
- Page 718 and 719:
702 AEROSOL DRUG DELIVERY low inter
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704 AEROSOL DRUG DELIVERY Transpare
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706 AEROSOL DRUG DELIVERY of the cl
- Page 724 and 725:
708 AEROSOL DRUG DELIVERY is achiev
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710 AEROSOL DRUG DELIVERY Aerosol g
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712 AEROSOL DRUG DELIVERY REFERENCE
- Page 730 and 731:
714 AEROSOL DRUG DELIVERY 42. Witek
- Page 732 and 733:
716 AEROSOL DRUG DELIVERY 81. Ohmor
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718 AEROSOL DRUG DELIVERY 119. Lewi
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720 AEROSOL DRUG DELIVERY 153. Terz
- Page 738 and 739:
722 AEROSOL DRUG DELIVERY 189. Sham
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724 AEROSOL DRUG DELIVERY 225. Newh
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726 AEROSOL DRUG DELIVERY 263. Dolo
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5.9 OCULAR DRUG DELIVERY Ilva D. Ru
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CHALLENGES IN OCULAR DRUG DELIVERY
- Page 749 and 750:
CHALLENGES IN OCULAR DRUG DELIVERY
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CHALLENGES IN OCULAR DRUG DELIVERY
- Page 753 and 754:
FORMULATION APPROACHES TO IMPROVE O
- Page 755 and 756:
FORMULATION APPROACHES TO IMPROVE O
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Drug Fluorescein FORMULATION APPROA
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FORMULATION APPROACHES TO IMPROVE O
- Page 761 and 762:
FORMULATION APPROACHES TO IMPROVE O
- Page 763 and 764:
FORMULATION APPROACHES TO IMPROVE O
- Page 765 and 766:
FORMULATION APPROACHES TO IMPROVE O
- Page 767 and 768:
FORMULATION APPROACHES TO IMPROVE O
- Page 769 and 770:
is characterized by a transient ove
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REFERENCES 755 11. Klyce , S. D. ,
- Page 773 and 774:
REFERENCES 757 53. Saettone , M. F.
- Page 775 and 776:
REFERENCES 759 87. Lin , H. R. , an
- Page 777 and 778:
REFERENCES 761 122. Durrani , A. M.
- Page 779 and 780:
REFERENCES 763 158. Weyenberg , W.
- Page 781 and 782:
REFERENCES 765 of various ophthalmi
- Page 783:
REFERENCES 767 233. Grass , G. M. ,
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770 MICROEMULSIONS AS DRUG DELIVERY
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772 MICROEMULSIONS AS DRUG DELIVERY
- Page 790 and 791:
774 MICROEMULSIONS AS DRUG DELIVERY
- Page 792 and 793:
776 MICROEMULSIONS AS DRUG DELIVERY
- Page 794 and 795:
778 MICROEMULSIONS AS DRUG DELIVERY
- Page 796 and 797:
780 MICROEMULSIONS AS DRUG DELIVERY
- Page 798 and 799:
782 MICROEMULSIONS AS DRUG DELIVERY
- Page 800 and 801:
784 MICROEMULSIONS AS DRUG DELIVERY
- Page 802 and 803:
786 MICROEMULSIONS AS DRUG DELIVERY
- Page 804 and 805:
788 MICROEMULSIONS AS DRUG DELIVERY
- Page 806 and 807:
790 MICROEMULSIONS AS DRUG DELIVERY
- Page 808 and 809:
792 MICROEMULSIONS AS DRUG DELIVERY
- Page 810 and 811:
794 TRANSDERMAL DRUG DELIVERY 5.11.
- Page 812 and 813:
796 TRANSDERMAL DRUG DELIVERY conta
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798 TRANSDERMAL DRUG DELIVERY 5.11.
- Page 816 and 817:
800 TRANSDERMAL DRUG DELIVERY FIGUR
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802 TRANSDERMAL DRUG DELIVERY a rat
- Page 820 and 821:
804 TRANSDERMAL DRUG DELIVERY passi
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806 TRANSDERMAL DRUG DELIVERY 19. E
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5.12 VAGINAL DRUG DELIVERY Jos é d
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Therefore, this chapter discusses t
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THE HUMAN VAGINA 813 thetic innerva
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THE HUMAN VAGINA 815 the upper repr
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THE HUMAN VAGINA 817 tant in the re
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GENERAL FEATURES OF VAGINAL DRUG DE
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Although this strategy may enhance
- Page 839 and 840:
VAGINAL DRUG DELIVERY SYSTEMS 823 a
- Page 841 and 842:
VAGINAL DRUG DELIVERY SYSTEMS 825 f
- Page 843 and 844:
VAGINAL DRUG DELIVERY SYSTEMS 827 f
- Page 845 and 846:
Amount released, μg/day 800 700 60
- Page 847 and 848:
VAGINAL DRUG DELIVERY SYSTEMS 831 5
- Page 849 and 850:
TABLE 4 Examples of Mucoadhesive Po
- Page 851 and 852:
VAGINAL DRUG DELIVERY SYSTEMS 835 i
- Page 853 and 854:
PHARMACEUTICAL EVALUATION OF VAGINA
- Page 855 and 856:
PHARMACEUTICAL EVALUATION OF VAGINA
- Page 857 and 858:
PHARMACEUTICAL EVALUATION OF VAGINA
- Page 859 and 860:
CLINICAL USAGE AND POTENTIAL OF VAG
- Page 861 and 862:
CLINICAL USAGE AND POTENTIAL OF VAG
- Page 863 and 864:
CLINICAL USAGE AND POTENTIAL OF VAG
- Page 865 and 866:
CLINICAL USAGE AND POTENTIAL OF VAG
- Page 867 and 868:
CLINICAL USAGE AND POTENTIAL OF VAG
- Page 869 and 870:
TABLE 6 Selected Drugs Administered
- Page 871 and 872:
Selected Veterinary Vaginal Drug De
- Page 873 and 874:
REFERENCES 857 Much work remains to
- Page 875 and 876:
REFERENCES 859 33. Hocini , H. , Ba
- Page 877 and 878:
REFERENCES 861 70. Kristmundsdottir
- Page 879 and 880:
REFERENCES 863 105. McClelland , R.
- Page 881 and 882:
REFERENCES 865 141. Kuyoh , M. A. ,
- Page 883 and 884:
REFERENCES 867 178. Ondracek , J. ,
- Page 885 and 886:
REFERENCES 869 212. Bagga , R. , Ra
- Page 887 and 888:
REFERENCES 871 244. International W
- Page 889 and 890:
REFERENCES 873 276. Mor , E. , Saad
- Page 891 and 892:
REFERENCES 875 310. Saltzman , W. M
- Page 893 and 894:
REFERENCES 877 vaginal microbicides
- Page 895:
SECTION 6 TABLET PRODUCTION
- Page 898 and 899:
882 PHARMACEUTICAL PREFORMULATION 6
- Page 900 and 901:
884 PHARMACEUTICAL PREFORMULATION E
- Page 902 and 903:
886 PHARMACEUTICAL PREFORMULATION T
- Page 904 and 905:
888 PHARMACEUTICAL PREFORMULATION T
- Page 906 and 907:
890 PHARMACEUTICAL PREFORMULATION T
- Page 908 and 909:
892 PHARMACEUTICAL PREFORMULATION p
- Page 910 and 911:
894 PHARMACEUTICAL PREFORMULATION T
- Page 912 and 913:
896 PHARMACEUTICAL PREFORMULATION T
- Page 914 and 915:
898 PHARMACEUTICAL PREFORMULATION l
- Page 916 and 917:
900 PHARMACEUTICAL PREFORMULATION T
- Page 918 and 919:
902 PHARMACEUTICAL PREFORMULATION s
- Page 920 and 921:
904 PHARMACEUTICAL PREFORMULATION C
- Page 922 and 923:
906 PHARMACEUTICAL PREFORMULATION p
- Page 924 and 925:
908 PHARMACEUTICAL PREFORMULATION C
- Page 926 and 927:
910 PHARMACEUTICAL PREFORMULATION T
- Page 928 and 929:
912 PHARMACEUTICAL PREFORMULATION D
- Page 930 and 931:
914 PHARMACEUTICAL PREFORMULATION C
- Page 932 and 933:
916 PHARMACEUTICAL PREFORMULATION u
- Page 934 and 935:
918 PHARMACEUTICAL PREFORMULATION d
- Page 936 and 937:
920 PHARMACEUTICAL PREFORMULATION q
- Page 938 and 939:
922 PHARMACEUTICAL PREFORMULATION w
- Page 940 and 941:
924 PHARMACEUTICAL PREFORMULATION C
- Page 942 and 943:
926 PHARMACEUTICAL PREFORMULATION T
- Page 944 and 945:
928 PHARMACEUTICAL PREFORMULATION a
- Page 946 and 947:
930 PHARMACEUTICAL PREFORMULATION a
- Page 949 and 950:
6.2 ROLE OF PREFORMULATION IN DEVEL
- Page 951 and 952:
maceutics ” documentation forms a
- Page 953 and 954:
e altered without any change in the
- Page 955 and 956:
Solubility Heat flow II I T m,II Ts
- Page 957 and 958:
TABLE 2 Techniques to Characterize
- Page 959 and 960:
Percent weight loss Heat flow (a) (
- Page 961 and 962:
Heat flow Intensity 100 50 Endother
- Page 963 and 964:
Change in mass (%) PHYSICAL/BULK CH
- Page 965 and 966:
6.2.2.6 Powder Flow and Compressibi
- Page 967 and 968:
Solvent required for 1 gm of solid
- Page 969 and 970:
⎧ 100 ⎪ Ka 1+10 Percent ionized
- Page 971 and 972:
Percent Ionization Percent Ionizati
- Page 973 and 974:
SOLUBILITY CHARACTERISTICS 957 para
- Page 975 and 976:
SOLUBILITY CHARACTERISTICS 959 of p
- Page 977 and 978:
Dissolution studies pH solubility p
- Page 979 and 980:
High Permeability Low SOLUBILITY CH
- Page 981 and 982:
is evident form the fact [51] that
- Page 983 and 984:
independent of initial drug concent
- Page 985 and 986:
STABILITY CHARACTERISTICS 969 drug
- Page 987 and 988:
6.2.5 CONCLUSIONS Preformulation te
- Page 989 and 990:
REFERENCES 973 16. Huang , L. , and
- Page 991:
54. 55. 56. REFERENCES 975 IFAMA (
- Page 994 and 995:
978 TABLET DESIGN 6.3.9.3 Case Stud
- Page 996 and 997:
980 TABLET DESIGN Another reason, t
- Page 998 and 999:
982 TABLET DESIGN E: This ensures t
- Page 1000 and 1001:
984 TABLET DESIGN substance would b
- Page 1002 and 1003:
986 TABLET DESIGN Plasticity 1.0 0.
- Page 1004 and 1005:
988 TABLET DESIGN Drug release (%)
- Page 1006 and 1007:
990 TABLET DESIGN FIGURE 9 Dissolut
- Page 1008 and 1009:
992 TABLET DESIGN TABLE 2 Number 1
- Page 1010 and 1011:
994 TABLET DESIGN Formulation Table
- Page 1012 and 1013:
996 TABLET DESIGN TABLE 4 Theophyll
- Page 1014 and 1015:
998 TABLET DESIGN often very fi ne,
- Page 1016 and 1017:
1000 TABLE 6 Formulations by Wet Gr
- Page 1018 and 1019:
1002 TABLET DESIGN 6.3.6.2 FIGURE 1
- Page 1020 and 1021:
1004 TABLET DESIGN TABLE 9 Papaveri
- Page 1022 and 1023:
1006 TABLET DESIGN TABLE 12 Weight
- Page 1024 and 1025:
1008 TABLET DESIGN (3.179 and 4.500
- Page 1026 and 1027:
1010 TABLET DESIGN TABLE 14 Run Ord
- Page 1028 and 1029:
1012 TABLET DESIGN Regression coeff
- Page 1030 and 1031:
1014 TABLET DESIGN to being the out
- Page 1032 and 1033:
1016 TABLET DESIGN Mechanical Prope
- Page 1034 and 1035:
1018 TABLET DESIGN drawbacks (unsaf
- Page 1036 and 1037:
1020 TABLET DESIGN TABLE 16 Basic F
- Page 1038 and 1039:
1022 TABLET DESIGN PEG (e.g., Macro
- Page 1040 and 1041:
1024 TABLET DESIGN 0.45% 0.40% 0.35
- Page 1042 and 1043:
1026 TABLET DESIGN FIGURE 34 Granul
- Page 1044 and 1045:
1028 TABLET DESIGN TABLE 19 SEPIFIL
- Page 1046 and 1047:
1030 TABLET DESIGN (c) Blistering D
- Page 1048 and 1049:
1032 TABLET DESIGN % Dextromethorph
- Page 1050 and 1051:
1034 TABLET DESIGN (a) (b) 500 μm
- Page 1052 and 1053:
1036 TABLET DESIGN threshold p c1 a
- Page 1054 and 1055:
1038 TABLET DESIGN TABLE 24 Composi
- Page 1056 and 1057:
1040 TABLET DESIGN Korsmeyer - Pepp
- Page 1058 and 1059:
1042 TABLET DESIGN % Water uptake/d
- Page 1060 and 1061:
1044 TABLET DESIGN FIGURE 47 Temper
- Page 1062 and 1063:
1046 TABLET DESIGN REFERENCES 1. Un
- Page 1064 and 1065:
1048 TABLET DESIGN 34. Congreve , M
- Page 1066 and 1067:
1050 TABLET DESIGN 73. Miranda , A.
- Page 1069 and 1070:
6.4 TABLET PRODUCTION SYSTEMS Katha
- Page 1071 and 1072:
PHYSICS OF TABLET FORMATION 1055 en
- Page 1073 and 1074:
Tablet production systems can be op
- Page 1075 and 1076:
TABLETING MACHINES 1059 Eccentric T
- Page 1077 and 1078:
TABLETING MACHINES 1061 In Figure 4
- Page 1079 and 1080:
TABLETING MACHINE SIMULATORS (COMPA
- Page 1081 and 1082:
TABLETING MACHINE SIMULATORS (COMPA
- Page 1083 and 1084:
However, for mechanical compaction
- Page 1085 and 1086:
INSTRUMENTATION OF TABLETING MACHIN
- Page 1087 and 1088:
Force (kN) FIGURE 13 ANALYSIS OF TA
- Page 1089 and 1090:
TABLE 4 Source Emschermann [91] (Fi
- Page 1091 and 1092:
TABLE 6 Parameters Directly Deduced
- Page 1093 and 1094:
TABLE 7 Parameters Calculated from
- Page 1095 and 1096:
ANALYSIS OF TABLETING PROCESS 1079
- Page 1097 and 1098:
TABLE 8 Source 3D model [143, 144,
- Page 1099 and 1100:
6.4.11 SPECIAL ACCESSORIES OF TABLE
- Page 1101 and 1102:
usually tends to vary. However, the
- Page 1103 and 1104:
ing at punches and dies. Low produc
- Page 1105 and 1106:
REFERENCES 1089 24. Elamin , A. , S
- Page 1107 and 1108:
REFERENCES 1091 64. Yeh , C. , Alta
- Page 1109 and 1110:
REFERENCES 1093 100. Armstrong , N.
- Page 1111 and 1112:
REFERENCES 1095 140. Kuentz , M. ,
- Page 1113 and 1114:
REFERENCES 1097 178. Hauschild , K.
- Page 1115 and 1116:
6.5 CONTROLLED RELEASE OF DRUGS FRO
- Page 1117 and 1118:
INTRODUCTION 1101 ings, and their e
- Page 1119 and 1120:
needed to circulate them [57] . Typ
- Page 1121 and 1122:
APPLICATIONS 1105 stream. During dr
- Page 1123 and 1124:
APPLICATIONS 1107 TABLE 1 Theophyll
- Page 1125 and 1126:
APPLICATIONS 1109 FIGURE 1 Release
- Page 1127 and 1128:
(a) (b) APPLICATIONS 1111 FIGURE 3
- Page 1129 and 1130:
APPLICATIONS 1113 FIGURE 5 Ternary
- Page 1131 and 1132:
APPLICATIONS 1115 of the drug, dC/d
- Page 1133 and 1134:
APPLICATIONS 1117 FIGURE 9 Ternary
- Page 1135 and 1136:
Release rate (mg/min) 0.40 0.30 0.2
- Page 1137 and 1138:
REFERENCES REFERENCES 1121 1. Lange
- Page 1139 and 1140:
REFERENCES 1123 37. Lin , Y - K. ,
- Page 1141 and 1142:
REFERENCES 1125 73. St - Onge , L.
- Page 1143 and 1144:
REFERENCES 1127 107. Lai , J. - Y.
- Page 1145 and 1146:
APPENDIX 1129 FIGURE A3 Release of
- Page 1147 and 1148:
APPENDIX 1131 FIGURE A7 Release of
- Page 1149 and 1150:
6.6 TABLET COMPRESSION Helton M. M.
- Page 1151 and 1152:
during compression, which will also
- Page 1153 and 1154:
of powder mixtures is usually chara
- Page 1155 and 1156:
lose in combination with either tal
- Page 1157 and 1158:
Due to the signifi cant nonlinearit
- Page 1159 and 1160:
EQUIPMENT FOR TABLET COMPRESSION 11
- Page 1161 and 1162:
Product Fill cam (mm) column height
- Page 1163 and 1164:
TABLET PRESS TOOLING 1147 TABLE 1 T
- Page 1165 and 1166:
TABLET PRESS TOOLING 1149 7. Tungst
- Page 1167 and 1168:
FIGURE 6 Tooling standards confi gu
- Page 1169 and 1170:
6.6.7 TABLE ENGRAVING Engraving is
- Page 1171 and 1172:
Shallow and standard concave tablet
- Page 1173 and 1174:
is the most popular bisect confi gu
- Page 1175 and 1176:
PROBLEMS DURING TABLET MANUFACTURIN
- Page 1177 and 1178:
thus reducing a potential variation
- Page 1179:
REFERENCES 1163 27. Train , D. ( 19
- Page 1182 and 1183:
1166 EFFECTS OF GRINDING IN PHARMAC
- Page 1184 and 1185:
1168 EFFECTS OF GRINDING IN PHARMAC
- Page 1186 and 1187:
1170 EFFECTS OF GRINDING IN PHARMAC
- Page 1188 and 1189: 1172 EFFECTS OF GRINDING IN PHARMAC
- Page 1190 and 1191: 1174 EFFECTS OF GRINDING IN PHARMAC
- Page 1192 and 1193: 1176 EFFECTS OF GRINDING IN PHARMAC
- Page 1194 and 1195: 1178 EFFECTS OF GRINDING IN PHARMAC
- Page 1196 and 1197: 1180 EFFECTS OF GRINDING IN PHARMAC
- Page 1198 and 1199: 1182 EFFECTS OF GRINDING IN PHARMAC
- Page 1200 and 1201: 1184 EFFECTS OF GRINDING IN PHARMAC
- Page 1202 and 1203: 1186 EFFECTS OF GRINDING IN PHARMAC
- Page 1204 and 1205: 1188 EFFECTS OF GRINDING IN PHARMAC
- Page 1206 and 1207: 1190 EFFECTS OF GRINDING IN PHARMAC
- Page 1208 and 1209: 1192 ORAL EXTENDED-RELEASE FORMULAT
- Page 1210 and 1211: 1194 ORAL EXTENDED-RELEASE FORMULAT
- Page 1212 and 1213: 1196 ORAL EXTENDED-RELEASE FORMULAT
- Page 1214 and 1215: 1198 ORAL EXTENDED-RELEASE FORMULAT
- Page 1216 and 1217: 1200 ORAL EXTENDED-RELEASE FORMULAT
- Page 1218 and 1219: 1202 ORAL EXTENDED-RELEASE FORMULAT
- Page 1220 and 1221: 1204 ORAL EXTENDED-RELEASE FORMULAT
- Page 1222 and 1223: 1206 ORAL EXTENDED-RELEASE FORMULAT
- Page 1224 and 1225: 1208 ORAL EXTENDED-RELEASE FORMULAT
- Page 1226 and 1227: 1210 ORAL EXTENDED-RELEASE FORMULAT
- Page 1228 and 1229: 1212 ORAL EXTENDED-RELEASE FORMULAT
- Page 1230 and 1231: 1214 ORAL EXTENDED-RELEASE FORMULAT
- Page 1232 and 1233: 1216 ORAL EXTENDED-RELEASE FORMULAT
- Page 1234 and 1235: 1218 ORAL EXTENDED-RELEASE FORMULAT
- Page 1236 and 1237: 1220 ORAL EXTENDED-RELEASE FORMULAT
- Page 1241 and 1242: 7.1 CYCLODEXTRIN - BASED NANOMATERI
- Page 1243 and 1244: OH (3) OH (2) HOCH 2 HOCH 2 O O OH
- Page 1245 and 1246: APPLICATIONS OF CYCLODEXTRINS IN NA
- Page 1247 and 1248: Percentage of release 100 90 80 70
- Page 1249 and 1250: APPLICATIONS OF CYCLODEXTRINS IN NA
- Page 1251 and 1252: APPLICATIONS OF CYCLODEXTRINS IN NA
- Page 1253 and 1254: APPLICATIONS OF CYCLODEXTRINS IN NA
- Page 1255 and 1256: O APPLICATIONS OF CYCLODEXTRINS IN
- Page 1257 and 1258: β - CDC6 loaded with the model dru
- Page 1259 and 1260: REFERENCES 1243 13. Stella , V. J.
- Page 1261 and 1262: REFERENCES 1245 49. Dodziuk , H. ,
- Page 1263: REFERENCES 1247 81. Memi şo ğlu -
- Page 1266 and 1267: 1250 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1268 and 1269: 1252 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1270 and 1271: 1254 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1272 and 1273: 1256 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1274 and 1275: 1258 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1276 and 1277: 1260 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1278 and 1279: 1262 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1280 and 1281: 1264 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1282 and 1283: 1266 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1284 and 1285: 1268 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1286 and 1287: 1270 NANOTECHNOLOGY IN PHARMACEUTIC
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1272 NANOTECHNOLOGY IN PHARMACEUTIC
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1274 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1292 and 1293:
1276 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1294 and 1295:
1278 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1296 and 1297:
1280 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1298 and 1299:
1282 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1300 and 1301:
1284 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1302 and 1303:
1286 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1304 and 1305:
1288 NANOTECHNOLOGY IN PHARMACEUTIC
- Page 1306 and 1307:
1290 PHARMACEUTICAL NANOSYSTEMS 7.3
- Page 1308 and 1309:
1292 PHARMACEUTICAL NANOSYSTEMS TAB
- Page 1310 and 1311:
1294 PHARMACEUTICAL NANOSYSTEMS TAB
- Page 1312 and 1313:
1296 PHARMACEUTICAL NANOSYSTEMS Lam
- Page 1314 and 1315:
1298 PHARMACEUTICAL NANOSYSTEMS 7.3
- Page 1316 and 1317:
1300 PHARMACEUTICAL NANOSYSTEMS sta
- Page 1318 and 1319:
1302 PHARMACEUTICAL NANOSYSTEMS TAB
- Page 1320 and 1321:
1304 PHARMACEUTICAL NANOSYSTEMS har
- Page 1322 and 1323:
1306 PHARMACEUTICAL NANOSYSTEMS TAB
- Page 1324 and 1325:
1308 PHARMACEUTICAL NANOSYSTEMS Sur
- Page 1326 and 1327:
1310 PHARMACEUTICAL NANOSYSTEMS Aut
- Page 1328 and 1329:
1312 PHARMACEUTICAL NANOSYSTEMS ®
- Page 1330 and 1331:
1314 PHARMACEUTICAL NANOSYSTEMS 55.
- Page 1332 and 1333:
1316 PHARMACEUTICAL NANOSYSTEMS 100
- Page 1334 and 1335:
1318 PHARMACEUTICAL NANOSYSTEMS 147
- Page 1336 and 1337:
1320 PHARMACEUTICAL NANOSYSTEMS 191
- Page 1338 and 1339:
1322 PHARMACEUTICAL NANOSYSTEMS 230
- Page 1340 and 1341:
1324 PHARMACEUTICAL NANOSYSTEMS Nan
- Page 1343 and 1344:
7.4 OIL - IN - WATER NANOSIZED EMUL
- Page 1345 and 1346:
GENERATIONS OF OIL-IN-WATER NANOSIZ
- Page 1347 and 1348:
GENERATIONS OF OIL-IN-WATER NANOSIZ
- Page 1349 and 1350:
GENERATIONS OF OIL-IN-WATER NANOSIZ
- Page 1351 and 1352:
GENERATIONS OF OIL-IN-WATER NANOSIZ
- Page 1353 and 1354:
GENERATIONS OF OIL-IN-WATER NANOSIZ
- Page 1355 and 1356:
GENERATIONS OF OIL-IN-WATER NANOSIZ
- Page 1357 and 1358:
DRUG-FREE/LOADED OIL-IN-WATER NANOS
- Page 1359 and 1360:
EXCIPIENT INCLUSION: OIL-IN-WATER N
- Page 1361 and 1362:
EXCIPIENT INCLUSION: OIL-IN-WATER N
- Page 1363 and 1364:
MEDICAL APPLICATIONS OF OIL-IN-WATE
- Page 1365 and 1366:
MEDICAL APPLICATIONS OF OIL-IN-WATE
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MEDICAL APPLICATIONS OF OIL-IN-WATE
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MEDICAL APPLICATIONS OF OIL-IN-WATE
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evaluation of the lipid hydroperoxi
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REFERENCES 1357 21. Ott , G. , Sing
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REFERENCES 1359 57. Harris , J. M.
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REFERENCES 1361 94. Kim , Y. J. , K
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REFERENCES 1363 131. Swietlikowska
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REFERENCES 1365 167. Acheampong , A
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INDEX Abortifacients, 850 Acyclovir
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Lung cancer, 497-502 Lung toxicity,
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