Pharmaceutical Manufacturing Handbook: Production and

6.3
TABLET DESIGN
Eddy Castellanos Gil , 1,2,3
Isidoro
3
Bernard Bataille
Caraballo , 2
and
1
Center of Pharmaceutical Chemistry and University of Havana, Havana, Cuba
2
University of Sevilla, Seville, Spain
3
University of Montpellier 1, Montpellier, France
Contents
6.3.1 Introduction
6.3.2 Tableting Cycle
6.3.3 Limitations for Direct Compression
6.3.4 Previous Granulation: Biopharmaceutical Versus Technological Properties
6.3.5 Tablet Design for Matrix System
6.3.5.1 Controlled - Release Tablet by Direct Compression and Wet Granulation
6.3.6 Tablet Design with Natural Products
6.3.6.1 Tablet Design from Aqueous Plant Extract
6.3.6.2 Natural Product as Vehicle for Manufactured Tablets
6.3.6.3 Natural Product as Vehicle for Controlled - Release System
6.3.6.4 Mechanism of Soluble Principle Active Propranolol Hydrochloride and
Lobenzarit Disodium from Dextran Tablets
6.3.7 Design Tools of Tablet Formulation
6.3.7.1 MODDE 4.0
6.3.7.2 iTAB
6.3.7.3 Percolation Theory
6.3.7.4 Artifi cial Neural Networks
6.3.8 Coating Systems
6.3.8.1 Subcoating of Tablet Cores as a Barrier to Water
6.3.8.2 Kollidon VA 64
6.3.8.3 SEPIFILM
6.3.9 Development of Pharmaceutical Tablets Using Percolation Theory
6.3.9.1 Case Study: Optimization of Inert Matrix Tablets for Controlled Release of
Dextromethorphan Hydrobromide
6.3.9.2 Critical Points of Hydrophilic Matrix Tablets
Pharmaceutical Manufacturing Handbook: Production and Processes, edited by Shayne Cox Gad
Copyright © 2008 John Wiley & Sons, Inc.
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