Pharmaceutical Manufacturing Handbook: Production and

3.1
FROM PILOT PLANT TO
MANUFACTURING: EFFECT OF
SCALE - UP ON OPERATION OF
JACKETED REACTORS
B. Wayne Bequette
Rensselaer Polytechnic Institute, Troy, New York
Contents
3.1.1
3.1.2
3.1.3
3.1.4
3.1.5
3.1.6
Motivation
Background
3.1.2.1 Pharmaceutical Process Development
3.1.2.2 Batch Reactors
3.1.2.3 Reaction Calorimetry
Laboratory Vessels and Reaction Calorimeters
3.1.3.1 Material and Energy Balances
3.1.3.2 Estimating Fluid Properties and Heat Transfer Coeffi cients from Calorimeter
Data
3.1.3.3 Estimating Heat Flows
3.1.3.4 Relating Heat Flows and Conversion
3.1.3.5 Semibatch Reactions
3.1.3.6 Rapid Scale - Up Relationships
3.1.3.7 Strategy under a Cooling System Failure
Heat Transfer in Process Vessels
3.1.4.1 Heat Transfer Relationships
3.1.4.2 Effect of Reactor Type, Jacket Heat Transfer Fluid, and Reactor Fluid
Viscosity
3.1.4.3 Pilot - and Production - Scale Experiments
Dynamic Simulation Studies
Summary
References
Pharmaceutical Manufacturing Handbook: Production and Processes, edited by Shayne Cox Gad
Copyright © 2008 John Wiley & Sons, Inc.
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