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PHARMACEUTICAL MANUFACTURING HANDBO
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PHARMACEUTICAL MANUFACTURING HANDBO
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CONTRIBUTORS Susanna Abrahms é n -
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CONTRIBUTORS vii Eddy Castellanos G
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CONTENTS PREFACE xiii SECTION 1 MAN
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CONTENTS xi 5.11 Transdermal Drug D
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SECTION 1 MANUFACTURING SPECIALTIES
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4 BIOTECHNOLOGY-DERIVED DRUG PRODUC
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6 BIOTECHNOLOGY-DERIVED DRUG PRODUC
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8 BIOTECHNOLOGY-DERIVED DRUG PRODUC
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10 BIOTECHNOLOGY-DERIVED DRUG PRODU
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12 BIOTECHNOLOGY-DERIVED DRUG PRODU
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14 BIOTECHNOLOGY-DERIVED DRUG PRODU
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16 BIOTECHNOLOGY-DERIVED DRUG PRODU
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18 BIOTECHNOLOGY-DERIVED DRUG PRODU
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20 BIOTECHNOLOGY-DERIVED DRUG PRODU
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22 BIOTECHNOLOGY-DERIVED DRUG PRODU
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24 BIOTECHNOLOGY-DERIVED DRUG PRODU
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26 BIOTECHNOLOGY-DERIVED DRUG PRODU
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28 BIOTECHNOLOGY-DERIVED DRUG PRODU
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30 BIOTECHNOLOGY-DERIVED DRUG PRODU
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32 BIOTECHNOLOGY-DERIVED DRUG PRODU
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34 REGULATORY CONSIDERATIONS IN APP
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36 REGULATORY CONSIDERATIONS IN APP
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38 REGULATORY CONSIDERATIONS IN APP
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40 REGULATORY CONSIDERATIONS IN APP
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42 REGULATORY CONSIDERATIONS IN APP
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44 REGULATORY CONSIDERATIONS IN APP
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46 REGULATORY CONSIDERATIONS IN APP
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48 REGULATORY CONSIDERATIONS IN APP
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50 REGULATORY CONSIDERATIONS IN APP
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52 REGULATORY CONSIDERATIONS IN APP
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54 REGULATORY CONSIDERATIONS IN APP
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56 REGULATORY CONSIDERATIONS IN APP
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1.3 RADIOPHARMACEUTICAL MANUFACTURI
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The terms tracer, radiotracer , and
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number of atoms that disintegrate d
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images that can also give quantitat
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PRODUCT DEVELOPMENT 67 Product Stab
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MANUFACTURING ASPECTS 69 stations s
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In general, the manufacturing of mo
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MANUFACTURING ASPECTS 73 Production
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PRODUCT MANUFACTURING 75 tainer. Th
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PRODUCT MANUFACTURING 77 practical
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PRODUCT MANUFACTURING 79 these radi
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PRODUCT MANUFACTURING 81 Most of th
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PRODUCT MANUFACTURING 83 PET Radiop
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PRODUCT MANUFACTURING 85 FIGURE 5 S
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PRODUCT MANUFACTURING 87 tions in t
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QUALITY CONSIDERATIONS 89 regulatio
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L1 L2 TC-MDP + Hydr. Tc TC-MDP + Tc
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EXTEMPORANEOUS PREPARATION OF RADIO
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Independent of which regulation app
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SECTION 2 ASEPTIC PROCESSING
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100 STERILE PRODUCT MANUFACTURING 2
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102 STERILE PRODUCT MANUFACTURING A
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104 STERILE PRODUCT MANUFACTURING T
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106 STERILE PRODUCT MANUFACTURING E
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108 STERILE PRODUCT MANUFACTURING I
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110 STERILE PRODUCT MANUFACTURING 2
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112 STERILE PRODUCT MANUFACTURING c
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114 STERILE PRODUCT MANUFACTURING 2
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116 STERILE PRODUCT MANUFACTURING 2
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118 STERILE PRODUCT MANUFACTURING i
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120 STERILE PRODUCT MANUFACTURING o
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122 STERILE PRODUCT MANUFACTURING a
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124 STERILE PRODUCT MANUFACTURING a
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126 STERILE PRODUCT MANUFACTURING e
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128 STERILE PRODUCT MANUFACTURING A
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130 STERILE PRODUCT MANUFACTURING 2
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132 STERILE PRODUCT MANUFACTURING p
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134 STERILE PRODUCT MANUFACTURING 2
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SECTION 3 FACILITY
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140 EFFECT OF SCALE-UP ON OPERATION
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142 EFFECT OF SCALE-UP ON OPERATION
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144 EFFECT OF SCALE-UP ON OPERATION
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146 EFFECT OF SCALE-UP ON OPERATION
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148 EFFECT OF SCALE-UP ON OPERATION
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150 EFFECT OF SCALE-UP ON OPERATION
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152 EFFECT OF SCALE-UP ON OPERATION
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154 EFFECT OF SCALE-UP ON OPERATION
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156 EFFECT OF SCALE-UP ON OPERATION
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158 EFFECT OF SCALE-UP ON OPERATION
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160 PACKAGING AND LABELING 3.2.1 3.
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162 PACKAGING AND LABELING signifi
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164 PACKAGING AND LABELING Although
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166 PACKAGING AND LABELING componen
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168 PACKAGING AND LABELING sions. T
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170 PACKAGING AND LABELING TABLE 1
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172 PACKAGING AND LABELING the stab
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174 PACKAGING AND LABELING and accu
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176 PACKAGING AND LABELING The safe
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178 PACKAGING AND LABELING If the p
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180 PACKAGING AND LABELING exposure
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182 PACKAGING AND LABELING In many
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184 PACKAGING AND LABELING Nonpharm
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186 PACKAGING AND LABELING In 1906,
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188 PACKAGING AND LABELING A medica
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190 PACKAGING AND LABELING The inst
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192 PACKAGING AND LABELING the poun
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194 PACKAGING AND LABELING • (4)
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196 PACKAGING AND LABELING In the c
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198 PACKAGING AND LABELING • Inte
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200 PACKAGING AND LABELING 27. U.S.
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202 CLEAN-FACILITY DESIGN, CONSTRUC
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204 CLEAN-FACILITY DESIGN, CONSTRUC
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206 CLEAN-FACILITY DESIGN, CONSTRUC
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208 CLEAN-FACILITY DESIGN, CONSTRUC
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210 CLEAN-FACILITY DESIGN, CONSTRUC
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212 CLEAN-FACILITY DESIGN, CONSTRUC
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214 CLEAN-FACILITY DESIGN, CONSTRUC
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216 CLEAN-FACILITY DESIGN, CONSTRUC
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218 CLEAN-FACILITY DESIGN, CONSTRUC
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220 CLEAN-FACILITY DESIGN, CONSTRUC
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222 CLEAN-FACILITY DESIGN, CONSTRUC
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224 CLEAN-FACILITY DESIGN, CONSTRUC
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226 CLEAN-FACILITY DESIGN, CONSTRUC
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228 CLEAN-FACILITY DESIGN, CONSTRUC
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230 CLEAN-FACILITY DESIGN, CONSTRUC
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232 CLEAN-FACILITY DESIGN, CONSTRUC
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4.1 SOLID DOSAGE FORMS Barbara R. C
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TABLE 2 Types of Solid Dosage Form
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(GI) tract or for systemic effects.
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EXCIPIENTS IN SOLID DOSE FORMULATIO
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EXCIPIENTS IN SOLID DOSE FORMULATIO
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HARD AND SOFT GELATIN CAPSULES 245
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HARD AND SOFT GELATIN CAPSULES 247
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HARD AND SOFT GELATIN CAPSULES 249
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participants from the FDA, industry
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in the mouth. Compressed lozenges (
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ittle fi lm, have no unpleasant tas
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CHEWING GUMS 257 4.1.10.2 Manufactu
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already dissolved in the saliva pri
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ORALLY DISINTEGRATING TABLETS 261 a
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tions. Some buccal formulations hav
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REFERENCES 265 32. Habib , W. , Kha
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268 SEMISOLID DOSAGES: OINTMENTS, C
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270 SEMISOLID DOSAGES: OINTMENTS, C
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272 SEMISOLID DOSAGES: OINTMENTS, C
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274 SEMISOLID DOSAGES: OINTMENTS, C
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276 SEMISOLID DOSAGES: OINTMENTS, C
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278 SEMISOLID DOSAGES: OINTMENTS, C
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280 SEMISOLID DOSAGES: OINTMENTS, C
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282 SEMISOLID DOSAGES: OINTMENTS, C
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284 SEMISOLID DOSAGES: OINTMENTS, C
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286 SEMISOLID DOSAGES: OINTMENTS, C
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288 SEMISOLID DOSAGES: OINTMENTS, C
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290 SEMISOLID DOSAGES: OINTMENTS, C
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292 SEMISOLID DOSAGES: OINTMENTS, C
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294 SEMISOLID DOSAGES: OINTMENTS, C
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296 SEMISOLID DOSAGES: OINTMENTS, C
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298 SEMISOLID DOSAGES: OINTMENTS, C
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300 SEMISOLID DOSAGES: OINTMENTS, C
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302 SEMISOLID DOSAGES: OINTMENTS, C
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304 SEMISOLID DOSAGES: OINTMENTS, C
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306 SEMISOLID DOSAGES: OINTMENTS, C
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308 SEMISOLID DOSAGES: OINTMENTS, C
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310 SEMISOLID DOSAGES: OINTMENTS, C
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312 SEMISOLID DOSAGES: OINTMENTS, C
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314 LIQUID DOSAGE FORMS 4.3.1 INTRO
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316 LIQUID DOSAGE FORMS 4.3.2 GENER
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318 LIQUID DOSAGE FORMS design, bui
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320 LIQUID DOSAGE FORMS tions with
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322 LIQUID DOSAGE FORMS Dosing Pump
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324 LIQUID DOSAGE FORMS However, th
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326 LIQUID DOSAGE FORMS Location of
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328 LIQUID DOSAGE FORMS Solid drugs
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330 LIQUID DOSAGE FORMS TABLE 3 Emu
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332 LIQUID DOSAGE FORMS Temperature
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334 LIQUID DOSAGE FORMS for viscosi
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336 LIQUID DOSAGE FORMS spectrum, s
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338 LIQUID DOSAGE FORMS Product Spe
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340 LIQUID DOSAGE FORMS Liquid, Ext
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342 LIQUID DOSAGE FORMS 7. Kourouna
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344 LIQUID DOSAGE FORMS 46. Miller
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5.1 CONTROLLED - RELEASE DOSAGE FOR
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CONTROLLED-RELEASE DRUG DELIVERY SY
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CONTROLLED-RELEASE FORMULATIONS 351
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dosage forms [12] . For example, or
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Degradation Liver Hydrolytic Enzyma
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CONTROLLED-RELEASE ORAL DOSAGE FORM
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DESIGN AND FABRICATION OF CONTROLLE
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DESIGN AND FABRICATION OF CONTROLLE
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DESIGN AND FABRICATION OF CONTROLLE
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DESIGN AND FABRICATION OF CONTROLLE
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TECHNOLOGIES FOR DEVELOPING TRANSDE
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TECHNOLOGIES FOR DEVELOPING TRANSDE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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RELEASE OF DRUGS FROM CONTROLLED-RE
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REFERENCES 387 16. Anal , A. K. ( 2
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REFERENCES 389 57. M ü ller , R. H
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REFERENCES 391 96. Sungthongjeen ,
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5.2 PROGRESS IN DESIGN OF BIODEGRAD
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INTRODUCTION 395 sequences. In addi
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TABLE 2 Injectable Peptide/Proteins
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PEPTIDE/PROTEIN-LOADED MICROSPHERE
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PEPTIDE/PROTEIN-LOADED MICROSPHERE
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PEPTIDE/PROTEIN-LOADED MICROSPHERE
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ANALYTICAL CHARACTERIZATION 405 imm
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IMMUNE SYSTEM INTERACTION WITH INJE
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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INJECTABLE PEPTIDE/PROTEIN-LOADED M
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PEPTIDE/PROTEIN ENCAPSULATED INTO B
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PEPTIDE/PROTEIN ENCAPSULATED INTO B
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PEPTIDE/PROTEIN ENCAPSULATED INTO B
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PEPTIDE/PROTEIN ENCAPSULATED INTO B
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REFERENCES 427 novel ways to reduce
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REFERENCES 429 31. Morlock , M. , K
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REFERENCES 431 63. Lam , X. M. , Du
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REFERENCES 433 95. van de Weert , M
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REFERENCES 435 130. Bilati , U. , A
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REFERENCES 437 166. Means , G. E. ,
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REFERENCES 439 bic poly(lactide -co
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REFERENCES 441 237. Singh , M. , Li
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444 LIPOSOMES AND DRUG DELIVERY (sm
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446 LIPOSOMES AND DRUG DELIVERY Con
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448 LIPOSOMES AND DRUG DELIVERY and
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450 LIPOSOMES AND DRUG DELIVERY tec
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452 LIPOSOMES AND DRUG DELIVERY 250
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454 LIPOSOMES AND DRUG DELIVERY a s
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456 LIPOSOMES AND DRUG DELIVERY For
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458 LIPOSOMES AND DRUG DELIVERY con
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460 LIPOSOMES AND DRUG DELIVERY The
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462 LIPOSOMES AND DRUG DELIVERY in
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464 LIPOSOMES AND DRUG DELIVERY c a
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466 LIPOSOMES AND DRUG DELIVERY Eve
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468 LIPOSOMES AND DRUG DELIVERY inc
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470 LIPOSOMES AND DRUG DELIVERY wit
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472 LIPOSOMES AND DRUG DELIVERY i.v
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474 LIPOSOMES AND DRUG DELIVERY for
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476 LIPOSOMES AND DRUG DELIVERY bet
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478 LIPOSOMES AND DRUG DELIVERY cli
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480 LIPOSOMES AND DRUG DELIVERY lea
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482 LIPOSOMES AND DRUG DELIVERY Vag
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484 LIPOSOMES AND DRUG DELIVERY TAB
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486 LIPOSOMES AND DRUG DELIVERY thr
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488 LIPOSOMES AND DRUG DELIVERY TAB
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490 LIPOSOMES AND DRUG DELIVERY tar
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492 LIPOSOMES AND DRUG DELIVERY tha
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494 LIPOSOMES AND DRUG DELIVERY wit
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496 LIPOSOMES AND DRUG DELIVERY Pul
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498 LIPOSOMES AND DRUG DELIVERY whi
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500 LIPOSOMES AND DRUG DELIVERY Inc
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502 LIPOSOMES AND DRUG DELIVERY Per
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504 LIPOSOMES AND DRUG DELIVERY can
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506 LIPOSOMES AND DRUG DELIVERY Tum
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508 LIPOSOMES AND DRUG DELIVERY 25.
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510 LIPOSOMES AND DRUG DELIVERY 60.
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512 LIPOSOMES AND DRUG DELIVERY 97.
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514 LIPOSOMES AND DRUG DELIVERY 136
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516 LIPOSOMES AND DRUG DELIVERY 170
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518 LIPOSOMES AND DRUG DELIVERY 202
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520 LIPOSOMES AND DRUG DELIVERY 237
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522 LIPOSOMES AND DRUG DELIVERY 271
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524 LIPOSOMES AND DRUG DELIVERY 310
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526 LIPOSOMES AND DRUG DELIVERY 346
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528 LIPOSOMES AND DRUG DELIVERY 378
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530 LIPOSOMES AND DRUG DELIVERY 408
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532 LIPOSOMES AND DRUG DELIVERY 437
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5.4 BIODEGRADABLE NANOPARTICLES Sud
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NATURAL BIODEGRADABLE POLYMERIC NAN
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NATURAL BIODEGRADABLE POLYMERIC NAN
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NATURAL BIODEGRADABLE POLYMERIC NAN
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and drug loading of gliadin nanopar
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SYNTHETIC BIODEGRADABLE POLYMERIC N
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APPLICATIONS OF BIODEGRADABLE NANOP
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PHYSICOCHEMICAL CHARACTERIZATION OF
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TARGETING NANOPARTICLES BY SURFACE
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5.4.9 CONCLUSIONS Biodegradable nan
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REFERENCES 555 of a model protein (
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REFERENCES 557 65. Kaul , G. , and
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REFERENCES 559 99. Carino , G. P. ,
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REFERENCES 561 133. Na , K. , Lee ,
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REFERENCES 563 168. Freitas , C. ,
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5.5 RECOMBINANT SACCHAROMYCES CEREV
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Potential Medical Applications of B
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BIODRUG CONCEPT USING YEAST AS VECT
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BIODRUG CONCEPT USING YEAST AS VECT
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Cumulative ileal delivery of viable
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tine [30] . No signal was detectabl
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ORAL FORMULATION OF RECOMBINANT YEA
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Cumulative ileal delivery of viable
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ORAL FORMULATION OF RECOMBINANT YEA
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Viable yeasts released (% of initia
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Steidler et al. [47] have already d
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REFERENCES 587 23. Steidler , L. (
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REFERENCES 589 nant yeasts as novel
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5.6 NASAL DELIVERY OF PEPTIDE AND N
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fi rst - pass metabolism and gut -
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[6] . The nasal blood vessels can b
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FACTORS INFLUENCING NASAL DRUG ABSO
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5.6.3.6 Type of Delivery Device FAC
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FACTORS INFLUENCING NASAL DRUG ABSO
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FIGURE 4 ( a ) Optinose multidose l
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Dogs, sheep, and monkeys can be kep
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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in solutions containing different c
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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NASAL DELIVERY OF PEPTIDE AND HIGH-
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Morphine plasma concentration (nmol
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Concentration (μg/L) 1000 100 10 1
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NASAL DELIVERY OF NONPEPTIDE MOLECU
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NASAL DELIVERY OF NONPEPTIDE MOLECU
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OPTION FOR DELIVERY OF DRUGS TO CEN
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pseudostratifi ed epithelium compri
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NASAL DELIVERY OF VACCINES 635 Howe
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TABLE 5 Continued Delivery System/A
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REFERENCES 639 23. Hardy , J. G. ,
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REFERENCES 641 60. Collens , W. S.
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REFERENCES 643 97. Eden , S. ( 1979
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REFERENCES 645 comparison with oral
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REFERENCES 647 172. Sakane , T. , A
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REFERENCES 649 213. McCluskie , M.
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5.7 NASAL POWDER DRUG DELIVERY Jele
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NASAL DRY POWDER FORMULATIONS 653 t
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POLYMERS IN NASAL POWDER DELIVERY S
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POLYMERS IN NASAL POWDER DELIVERY S
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MICROSPHERES AS NASAL DRUG DELIVERY
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MICROSPHERES AS NASAL DRUG DELIVERY
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MICROSPHERES AS NASAL DRUG DELIVERY
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MICROSPHERES AS NASAL DRUG DELIVERY
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TOXICOLOGICAL CONSIDERATIONS 667 et
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Summary of Research Work on Nasal D
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Powder Formulation Preparation Meth
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Powder Formulation Preparation Meth
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REFERENCES 675 19. Van der Lubben ,
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REFERENCES 677 54. Witschi , C. , a
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REFERENCES 679 91. Varshosaz , J. ,
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REFERENCES 681 126. Jorissen , M. ,
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684 AEROSOL DRUG DELIVERY 5.8.8 5.8
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686 AEROSOL DRUG DELIVERY other sig
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688 AEROSOL DRUG DELIVERY are a num
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690 AEROSOL DRUG DELIVERY 5.8.5 MET
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692 AEROSOL DRUG DELIVERY TABLE 1 S
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694 AEROSOL DRUG DELIVERY valve siz
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696 AEROSOL DRUG DELIVERY Ferrule U
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698 AEROSOL DRUG DELIVERY 5.8.5.6 A
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700 AEROSOL DRUG DELIVERY 5.8.5.10
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702 AEROSOL DRUG DELIVERY low inter
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704 AEROSOL DRUG DELIVERY Transpare
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706 AEROSOL DRUG DELIVERY of the cl
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708 AEROSOL DRUG DELIVERY is achiev
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710 AEROSOL DRUG DELIVERY Aerosol g
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712 AEROSOL DRUG DELIVERY REFERENCE
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714 AEROSOL DRUG DELIVERY 42. Witek
- Page 732 and 733:
716 AEROSOL DRUG DELIVERY 81. Ohmor
- Page 734 and 735: 718 AEROSOL DRUG DELIVERY 119. Lewi
- Page 736 and 737: 720 AEROSOL DRUG DELIVERY 153. Terz
- Page 738 and 739: 722 AEROSOL DRUG DELIVERY 189. Sham
- Page 740 and 741: 724 AEROSOL DRUG DELIVERY 225. Newh
- Page 742 and 743: 726 AEROSOL DRUG DELIVERY 263. Dolo
- Page 745 and 746: 5.9 OCULAR DRUG DELIVERY Ilva D. Ru
- Page 747 and 748: CHALLENGES IN OCULAR DRUG DELIVERY
- Page 749 and 750: CHALLENGES IN OCULAR DRUG DELIVERY
- Page 751 and 752: CHALLENGES IN OCULAR DRUG DELIVERY
- Page 753 and 754: FORMULATION APPROACHES TO IMPROVE O
- Page 755 and 756: FORMULATION APPROACHES TO IMPROVE O
- Page 757 and 758: Drug Fluorescein FORMULATION APPROA
- Page 759 and 760: FORMULATION APPROACHES TO IMPROVE O
- Page 761 and 762: FORMULATION APPROACHES TO IMPROVE O
- Page 763 and 764: FORMULATION APPROACHES TO IMPROVE O
- Page 765 and 766: FORMULATION APPROACHES TO IMPROVE O
- Page 767 and 768: FORMULATION APPROACHES TO IMPROVE O
- Page 769 and 770: is characterized by a transient ove
- Page 771 and 772: REFERENCES 755 11. Klyce , S. D. ,
- Page 773 and 774: REFERENCES 757 53. Saettone , M. F.
- Page 775 and 776: REFERENCES 759 87. Lin , H. R. , an
- Page 777 and 778: REFERENCES 761 122. Durrani , A. M.
- Page 779 and 780: REFERENCES 763 158. Weyenberg , W.
- Page 781 and 782: REFERENCES 765 of various ophthalmi
- Page 783: REFERENCES 767 233. Grass , G. M. ,
- Page 787 and 788: STRUCTURE AND FORMATION OF MICROEMU
- Page 789 and 790: oily phase, and the interfacial lay
- Page 791 and 792: CHARACTERIZE MICROEMULSIONS AND REL
- Page 793 and 794: CHARACTERIZE MICROEMULSIONS AND REL
- Page 795 and 796: study was conducted on systems comp
- Page 797 and 798: 5.10.6.1 Oral Drug Delivery MICROEM
- Page 799 and 800: MICROEMULSIONS AS DRUG DELIVERY SYS
- Page 801 and 802: REFERENCES 785 stability of incorpo
- Page 803 and 804: REFERENCES 787 22. Saint - Ruth , H
- Page 805 and 806: REFERENCES 789 58. Ktistis , G. ( 1
- Page 807 and 808: REFERENCES 791 94. Rhee , Y. S. , C
- Page 809 and 810: 5.11 TRANSDERMAL DRUG DELIVERY C. S
- Page 811 and 812: Drug plasma concentration FIGURE 1
- Page 813 and 814: PHYSIOLOGY AND CHARACTERISTICS OF H
- Page 815 and 816: Another important parameter when se
- Page 817 and 818: COMMERCIALLY AVAILABLE PATCHES 801
- Page 819 and 820: 5.11.8.1 Chemical Penetration Enhan
- Page 821 and 822: corneum much like the microneedle t
- Page 823: REFERENCES 807 40. Mitragotri , S.
- Page 826 and 827: 810 VAGINAL DRUG DELIVERY 5.12.5.6
- Page 828 and 829: 812 VAGINAL DRUG DELIVERY The vagin
- Page 830 and 831: 814 VAGINAL DRUG DELIVERY have mucu
- Page 832 and 833: 816 VAGINAL DRUG DELIVERY TABLE 1 C
- Page 834 and 835:
818 VAGINAL DRUG DELIVERY Menopausa
- Page 836 and 837:
820 VAGINAL DRUG DELIVERY 500 400 3
- Page 838 and 839:
822 VAGINAL DRUG DELIVERY spreadabi
- Page 840 and 841:
824 VAGINAL DRUG DELIVERY distribut
- Page 842 and 843:
826 VAGINAL DRUG DELIVERY improved
- Page 844 and 845:
828 VAGINAL DRUG DELIVERY FIGURE 4
- Page 846 and 847:
830 VAGINAL DRUG DELIVERY FIGURE 6
- Page 848 and 849:
832 VAGINAL DRUG DELIVERY 5.12.4.10
- Page 850 and 851:
834 VAGINAL DRUG DELIVERY availabil
- Page 852 and 853:
836 VAGINAL DRUG DELIVERY 5.12.4.12
- Page 854 and 855:
838 VAGINAL DRUG DELIVERY results.
- Page 856 and 857:
840 VAGINAL DRUG DELIVERY 5.12.5.6
- Page 858 and 859:
842 VAGINAL DRUG DELIVERY studies t
- Page 860 and 861:
844 VAGINAL DRUG DELIVERY subject i
- Page 862 and 863:
846 VAGINAL DRUG DELIVERY formulati
- Page 864 and 865:
848 VAGINAL DRUG DELIVERY FIGURE 8
- Page 866 and 867:
850 VAGINAL DRUG DELIVERY shown to
- Page 868 and 869:
852 VAGINAL DRUG DELIVERY poloxamer
- Page 870 and 871:
854 VAGINAL DRUG DELIVERY made. Ide
- Page 872 and 873:
856 VAGINAL DRUG DELIVERY FIGURE 9
- Page 874 and 875:
858 VAGINAL DRUG DELIVERY 13. Wagne
- Page 876 and 877:
860 VAGINAL DRUG DELIVERY 54. Corbo
- Page 878 and 879:
862 VAGINAL DRUG DELIVERY supposito
- Page 880 and 881:
864 VAGINAL DRUG DELIVERY 123. van
- Page 882 and 883:
866 VAGINAL DRUG DELIVERY nanospher
- Page 884 and 885:
868 VAGINAL DRUG DELIVERY 196. Jone
- Page 886 and 887:
870 VAGINAL DRUG DELIVERY Irritatio
- Page 888 and 889:
872 VAGINAL DRUG DELIVERY 261. Czei
- Page 890 and 891:
874 VAGINAL DRUG DELIVERY 293. Fowl
- Page 892 and 893:
876 VAGINAL DRUG DELIVERY 327. O
- Page 894 and 895:
878 VAGINAL DRUG DELIVERY 359. Rath
- Page 897 and 898:
6.1 PHARMACEUTICAL PREFORMULATION:
- Page 899 and 900:
tion. According to global Internati
- Page 901 and 902:
SELECTION OF PHARMACEUTICAL EXCIPIE
- Page 903 and 904:
SELECTION OF PHARMACEUTICAL EXCIPIE
- Page 905 and 906:
TABLE 4 Disintegrant Starch Commonl
- Page 907 and 908:
SELECTION OF PHARMACEUTICAL EXCIPIE
- Page 909 and 910:
SELECTION OF PHARMACEUTICAL EXCIPIE
- Page 911 and 912:
SELECTION OF PHARMACEUTICAL EXCIPIE
- Page 913 and 914:
DRUG-EXCIPIENT COMPATIBILITY 897 ap
- Page 915 and 916:
DRUG-EXCIPIENT COMPATIBILITY 899 in
- Page 917 and 918:
POWDER CHARACTERISTICS 901 their im
- Page 919 and 920:
POWDER CHARACTERISTICS 903 TABLE 13
- Page 921 and 922:
POWDER CHARACTERISTICS 905 Microsco
- Page 923 and 924:
Powder flow rate FIGURE 6 No flow b
- Page 925 and 926:
POWDER CHARACTERISTICS 909 Measurem
- Page 927 and 928:
V − V ε= V b p b V = 1− V POWD
- Page 929 and 930:
POWDER CHARACTERISTICS 913 The mois
- Page 931 and 932:
Tensile strength (Pa) 14 12 10 8 6
- Page 933 and 934:
POWDER CHARACTERISTICS 917 and poor
- Page 935 and 936:
infl uence the physicochemical prop
- Page 937 and 938:
Tablet disintegration is the import
- Page 939 and 940:
ability studies and from human stud
- Page 941 and 942:
Variables Affecting Dissolution In
- Page 943 and 944:
TABLET CHARACTERIZATION 927 The dif
- Page 945 and 946:
The requirements for content unifor
- Page 947:
REFERENCES 931 15. Simon , P. , Vev
- Page 950 and 951:
934 ROLE OF PREFORMULATION IN DEVEL
- Page 952 and 953:
936 ROLE OF PREFORMULATION IN DEVEL
- Page 954 and 955:
938 ROLE OF PREFORMULATION IN DEVEL
- Page 956 and 957:
940 ROLE OF PREFORMULATION IN DEVEL
- Page 958 and 959:
942 ROLE OF PREFORMULATION IN DEVEL
- Page 960 and 961:
944 ROLE OF PREFORMULATION IN DEVEL
- Page 962 and 963:
946 ROLE OF PREFORMULATION IN DEVEL
- Page 964 and 965:
948 ROLE OF PREFORMULATION IN DEVEL
- Page 966 and 967:
950 ROLE OF PREFORMULATION IN DEVEL
- Page 968 and 969:
952 ROLE OF PREFORMULATION IN DEVEL
- Page 970 and 971:
954 ROLE OF PREFORMULATION IN DEVEL
- Page 972 and 973:
956 ROLE OF PREFORMULATION IN DEVEL
- Page 974 and 975:
958 ROLE OF PREFORMULATION IN DEVEL
- Page 976 and 977:
960 ROLE OF PREFORMULATION IN DEVEL
- Page 978 and 979:
962 ROLE OF PREFORMULATION IN DEVEL
- Page 980 and 981:
964 ROLE OF PREFORMULATION IN DEVEL
- Page 982 and 983:
966 ROLE OF PREFORMULATION IN DEVEL
- Page 984 and 985:
968 ROLE OF PREFORMULATION IN DEVEL
- Page 986 and 987:
970 ROLE OF PREFORMULATION IN DEVEL
- Page 988 and 989:
972 ROLE OF PREFORMULATION IN DEVEL
- Page 990 and 991:
974 ROLE OF PREFORMULATION IN DEVEL
- Page 993 and 994:
6.3 TABLET DESIGN Eddy Castellanos
- Page 995 and 996:
TABLETING CYCLE 979 The eccentric p
- Page 997 and 998:
FIGURE 4 (a) (b) (c) TABLETING CYCL
- Page 999 and 1000:
TABLE 1 mm 3 4 5 6 7 8 9 10 11 12 1
- Page 1001 and 1002:
LIMITATIONS FOR DIRECT COMPRESSION
- Page 1003 and 1004:
Drug release (%) 120 100 80 60 40 2
- Page 1005 and 1006:
Beta Carotene Tablets (15 mg ) Form
- Page 1007 and 1008:
Lisinopril release (%) FIGURE 10 BI
- Page 1009 and 1010:
that do not compress well after wet
- Page 1011 and 1012:
Calcium phosphate, dibasic offers h
- Page 1013 and 1014:
FIGURE 11 Theophylline release (%)
- Page 1015 and 1016:
TABLET DESIGN WITH NATURAL PRODUCTS
- Page 1017 and 1018:
TABLE 7 Two Formulations for mangif
- Page 1019 and 1020:
TABLE 8 Weight Assay Disintegration
- Page 1021 and 1022:
TABLET DESIGN WITH NATURAL PRODUCTS
- Page 1023 and 1024:
has a regulatory effect upon the an
- Page 1025 and 1026:
DESIGN TOOLS OF TABLET FORMULATION
- Page 1027 and 1028:
Amount released PPL (%) 110 100 90
- Page 1029 and 1030:
DESIGN TOOLS OF TABLET FORMULATION
- Page 1031 and 1032:
Percolation threshold (ε c) FIGURE
- Page 1033 and 1034:
6.3.8 COATING SYSTEMS COATING SYSTE
- Page 1035 and 1036:
COATING SYSTEMS 1019 ences between
- Page 1037 and 1038:
Water absorption, % 8 7 6 5 4 3 2 1
- Page 1039 and 1040:
FIGURE 28 white. mg/h·m 0.9 0.8 0.
- Page 1041 and 1042:
(a) (b) FIGURE 31 ( a ) Tablet coat
- Page 1043 and 1044:
TABLE 18 Solid content Batch size,
- Page 1045 and 1046:
Percent released FIGURE 35 Tablet b
- Page 1047 and 1048:
PHARMACEUTICAL TABLETS USING PERCOL
- Page 1049 and 1050:
TABLE 23 Calculation of Tablet Prop
- Page 1051 and 1052:
PHARMACEUTICAL TABLETS USING PERCOL
- Page 1053 and 1054:
PHARMACEUTICAL TABLETS USING PERCOL
- Page 1055 and 1056:
TABLE 25 Aspect Ratios and Exponent
- Page 1057 and 1058:
K H (%min - 1/2)/% v/v excipient pl
- Page 1059 and 1060:
6.3.10 ULTRASOUND-ASSISTED TABLETIN
- Page 1061 and 1062:
ULTRASOUND-ASSISTED TABLETING (A NE
- Page 1063 and 1064:
REFERENCES 1047 18. S á nchez , G.
- Page 1065 and 1066:
REFERENCES 1049 54. Hess , H. , and
- Page 1067:
92. Mill á n , M. , and Caraballo
- Page 1070 and 1071:
1054 TABLET PRODUCTION SYSTEMS 6.4.
- Page 1072 and 1073:
1056 TABLET PRODUCTION SYSTEMS comp
- Page 1074 and 1075:
1058 TABLET PRODUCTION SYSTEMS and
- Page 1076 and 1077:
1060 TABLET PRODUCTION SYSTEMS FIGU
- Page 1078 and 1079:
1062 TABLET PRODUCTION SYSTEMS FIGU
- Page 1080 and 1081:
1064 TABLET PRODUCTION SYSTEMS FIGU
- Page 1082 and 1083:
1066 TABLET PRODUCTION SYSTEMS when
- Page 1084 and 1085:
1068 TABLET PRODUCTION SYSTEMS die
- Page 1086 and 1087:
1070 TABLET PRODUCTION SYSTEMS FIGU
- Page 1088 and 1089:
1072 TABLET PRODUCTION SYSTEMS TABL
- Page 1090 and 1091:
1074 TABLET PRODUCTION SYSTEMS Pres
- Page 1092 and 1093:
1076 TABLET PRODUCTION SYSTEMS Forc
- Page 1094 and 1095:
1078 TABLET PRODUCTION SYSTEMS In(1
- Page 1096 and 1097:
1080 TABLET PRODUCTION SYSTEMS In[1
- Page 1098 and 1099:
1082 TABLET PRODUCTION SYSTEMS [78,
- Page 1100 and 1101:
1084 TABLET PRODUCTION SYSTEMS FIGU
- Page 1102 and 1103:
1086 TABLET PRODUCTION SYSTEMS When
- Page 1104 and 1105:
1088 TABLET PRODUCTION SYSTEMS 3. P
- Page 1106 and 1107:
1090 TABLET PRODUCTION SYSTEMS 44.
- Page 1108 and 1109:
1092 TABLET PRODUCTION SYSTEMS 81.
- Page 1110 and 1111:
1094 TABLET PRODUCTION SYSTEMS 119.
- Page 1112 and 1113:
1096 TABLET PRODUCTION SYSTEMS 160.
- Page 1114 and 1115:
1098 TABLET PRODUCTION SYSTEMS 197.
- Page 1116 and 1117:
1100 CONTROLLED RELEASE OF DRUGS FR
- Page 1118 and 1119:
1102 CONTROLLED RELEASE OF DRUGS FR
- Page 1120 and 1121:
1104 CONTROLLED RELEASE OF DRUGS FR
- Page 1122 and 1123:
1106 CONTROLLED RELEASE OF DRUGS FR
- Page 1124 and 1125:
1108 CONTROLLED RELEASE OF DRUGS FR
- Page 1126 and 1127:
1110 CONTROLLED RELEASE OF DRUGS FR
- Page 1128 and 1129:
1112 CONTROLLED RELEASE OF DRUGS FR
- Page 1130 and 1131:
1114 CONTROLLED RELEASE OF DRUGS FR
- Page 1132 and 1133:
1116 CONTROLLED RELEASE OF DRUGS FR
- Page 1134 and 1135:
1118 CONTROLLED RELEASE OF DRUGS FR
- Page 1136 and 1137:
1120 CONTROLLED RELEASE OF DRUGS FR
- Page 1138 and 1139:
1122 CONTROLLED RELEASE OF DRUGS FR
- Page 1140 and 1141:
1124 CONTROLLED RELEASE OF DRUGS FR
- Page 1142 and 1143:
1126 CONTROLLED RELEASE OF DRUGS FR
- Page 1144 and 1145:
1128 CONTROLLED RELEASE OF DRUGS FR
- Page 1146 and 1147:
1130 CONTROLLED RELEASE OF DRUGS FR
- Page 1148 and 1149:
1132 CONTROLLED RELEASE OF DRUGS FR
- Page 1150 and 1151:
1134 TABLET COMPRESSION stages invo
- Page 1152 and 1153:
1136 TABLET COMPRESSION although on
- Page 1154 and 1155:
1138 TABLET COMPRESSION P P = + C a
- Page 1156 and 1157:
1140 TABLET COMPRESSION 4. Estimati
- Page 1158 and 1159:
1142 TABLET COMPRESSION from a hopp
- Page 1160 and 1161:
1144 TABLET COMPRESSION speed of th
- Page 1162 and 1163:
1146 TABLET COMPRESSION FIGURE 4 Co
- Page 1164 and 1165:
1148 TABLET COMPRESSION FIGURE 5 Id
- Page 1166 and 1167:
1150 TABLET COMPRESSION its low tou
- Page 1168 and 1169:
1152 TABLET COMPRESSION Standard TS
- Page 1170 and 1171:
1154 TABLET COMPRESSION A B C D E F
- Page 1172 and 1173:
1156 TABLET COMPRESSION Top view Pr
- Page 1174 and 1175:
1158 TABLET COMPRESSION particle si
- Page 1176 and 1177:
1160 TABLET COMPRESSION 6.6.10.3 Mo
- Page 1178 and 1179:
1162 TABLET COMPRESSION 7. Masteau
- Page 1181 and 1182:
6.7 EFFECTS OF GRINDING IN PHARMACE
- Page 1183 and 1184:
MILLING EQUIPMENT 1167 whereas smal
- Page 1185 and 1186:
Screen Product FIGURE 3 Hammers Ham
- Page 1187 and 1188:
inders, disintegrants, glidants, lu
- Page 1189 and 1190:
Airflow Press POWDER CHARACTERIZATI
- Page 1191 and 1192:
Powder flow Sample Process stream (
- Page 1193 and 1194:
Container 1 Container 1 Discard (a)
- Page 1195 and 1196:
Porous particles in container POWDE
- Page 1197 and 1198:
POWDER CHARACTERIZATION TECHNIQUES
- Page 1199 and 1200:
expansions or fractal dimensions);
- Page 1201 and 1202:
EFFECT OF PARTICLE SIZE REDUCTION O
- Page 1203 and 1204:
EFFECT OF PARTICLE SIZE REDUCTION O
- Page 1205 and 1206:
REFERENCES 1189 19. British Standar
- Page 1207 and 1208:
6.8 ORAL EXTENDED - RELEASE FORMULA
- Page 1209 and 1210:
INTRODUCTION 1193 line) together wi
- Page 1211 and 1212:
INTRODUCTION 1195 substance) instea
- Page 1213 and 1214:
of the drug particles/formulation a
- Page 1215 and 1216:
M A DCt t = ⎡ ε s ( 2C − C )
- Page 1217 and 1218:
method for insoluble matrix tablets
- Page 1219 and 1220:
MEMBRANE-COATED ORAL EXTENDED RELEA
- Page 1221 and 1222:
MEMBRANE-COATED ORAL EXTENDED RELEA
- Page 1223 and 1224:
Swelling front Diffusion front Eros
- Page 1225 and 1226:
dM Q = ∫ dt = kt 0 dt HYDROPHILIC
- Page 1227 and 1228:
TABLE 2 FDA Registered Oral ER Form
- Page 1229 and 1230:
6.8.6 OTHER ORAL ER FORMULATIONS OT
- Page 1231 and 1232:
REFERENCES 1215 15. Neau , S. H. ,
- Page 1233 and 1234:
REFERENCES 1217 54. Sousa , J. J. ,
- Page 1235 and 1236:
REFERENCES 1219 89. Ford , J. L. ,
- Page 1237 and 1238:
REFERENCES 1221 122. Talukdar , M.
- Page 1239:
SECTION 7 ROLE OF NANOTECHNOLOGY
- Page 1242 and 1243:
1226 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1244 and 1245:
1228 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1246 and 1247:
1230 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1248 and 1249:
1232 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1250 and 1251:
1234 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1252 and 1253:
1236 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1254 and 1255:
1238 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1256 and 1257:
1240 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1258 and 1259:
1242 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1260 and 1261:
1244 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1262 and 1263:
1246 CYCLODEXTRIN-BASED NANOMATERIA
- Page 1265 and 1266:
7.2 NANOTECHNOLOGY IN PHARMACEUTICA
- Page 1267 and 1268:
NANOMATERIALS 1251 tists regard mat
- Page 1269 and 1270:
NANOMATERIALS 1253 TABLE 1 Characte
- Page 1271 and 1272:
NANOMATERIALS 1255 sor molecules/pa
- Page 1273 and 1274:
TABLE 2 Continued Types of Nanomate
- Page 1275 and 1276:
H 3 C CH 3 N + CH 3 O O O O - P O O
- Page 1277 and 1278:
NANOTECHNOLOGY FOR DRUG DELIVERY 12
- Page 1279 and 1280:
entrapped drugs releasing [90] . So
- Page 1281 and 1282:
NANOTECHNOLOGY FOR DRUG DELIVERY 12
- Page 1283 and 1284:
NANOTECHNOLOGY FOR DRUG DELIVERY 12
- Page 1285 and 1286:
NANOTECHNOLOGY FOR DRUG DELIVERY 12
- Page 1287 and 1288:
NANOTECHNOLOGY FOR DRUG DELIVERY 12
- Page 1289 and 1290:
NANOTECHNOLOGY FOR DRUG DELIVERY 12
- Page 1291 and 1292:
NANOTECHNOLOGY FOR DRUG DELIVERY 12
- Page 1293 and 1294:
NANOTECHNOLOGY FOR DRUG DELIVERY 12
- Page 1295 and 1296:
NANOMEDICINE 1279 prises) visibly p
- Page 1297 and 1298:
REFERENCES 1281 16. http://www.whit
- Page 1299 and 1300:
REFERENCES 1283 55. Kam , N. W. S.
- Page 1301 and 1302:
REFERENCES 1285 92. Zhang , J. Q. ,
- Page 1303 and 1304:
REFERENCES 1287 126. Smart , S. K.
- Page 1305 and 1306:
7.3 PHARMACEUTICAL NANOSYSTEMS: MAN
- Page 1307 and 1308:
7.3.2 TAXONOMY OF NANOMEDICINE TECH
- Page 1309 and 1310:
TABLE 1 Continued Molecular medicin
- Page 1311 and 1312:
Applications of quantum dots includ
- Page 1313 and 1314:
7.3.5 MANUFACTURING TECHNOLOGIES Th
- Page 1315 and 1316:
Ratio of hydrodynamic radius, R H ,
- Page 1317 and 1318:
eplicated on the substrate, with na
- Page 1319 and 1320:
MANUFACTURING TECHNOLOGIES 1303 bel
- Page 1321 and 1322:
CHARACTERIZATION TECHNIQUES 1305 TA
- Page 1323 and 1324:
CHARACTERIZATION TECHNIQUES 1307 TA
- Page 1325 and 1326:
Limitations of AFM [255 - 257] Pote
- Page 1327 and 1328:
REFERENCES 1311 thelial cells, the
- Page 1329 and 1330:
REFERENCES 1313 34. Ostrander , K.
- Page 1331 and 1332:
REFERENCES 1315 77. Muangsiri , W.
- Page 1333 and 1334:
REFERENCES 1317 124. Caruso , F. ,
- Page 1335 and 1336:
REFERENCES 1319 170. Rogers , J. A.
- Page 1337 and 1338:
REFERENCES 1321 application: Synthe
- Page 1339 and 1340:
252. Fontaine , P. A. , et al. ( 19
- Page 1341:
Characterization Methods Binks , B.
- Page 1344 and 1345:
1328 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1346 and 1347:
1330 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1348 and 1349:
1332 Application TABLE 1 Selected M
- Page 1350 and 1351:
1334 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1352 and 1353:
1336 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1354 and 1355:
1338 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1356 and 1357:
1340 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1358 and 1359:
1342 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1360 and 1361:
1344 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1362 and 1363:
1346 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1364 and 1365:
1348 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1366 and 1367:
1350 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1368 and 1369:
1352 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1370 and 1371:
1354 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1372 and 1373:
1356 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1374 and 1375:
1358 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1376 and 1377:
1360 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1378 and 1379:
1362 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1380 and 1381:
1364 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1382 and 1383:
1366 OIL-IN-WATER NANOSIZED EMULSIO
- Page 1384 and 1385:
1368 INDEX Cholera toxin, 637 Cilio
- Page 1386:
1370 INDEX Production of radiopharm