4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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4. Hrvatski kongres kliniËke citologije / 1. Hrvatski simpozij analitiËke citologije / 2. Hrvatski simpozij citotehnologije 120 Klinička citologija - Posteri POLYOMAVIRUS ASSOCIATED NEPHROPATHY AFTER SIMULTANEOUS KIDNEY AND PANCREAS TRANSPLANTATION. CASE REPORT. Gracin S1 , Knotek M1 , Sabljar Matovinovic M1 , Kardum Skelin I1 , Ljubanovic D2 , Vidas Z1 1 Clinical hospital Merkur, Zagreb, Croatia. 2 Clinical hospital Dubrava, Zagreb, Croatia. In renal allograft recipient, immunosuppressive drug therapy is the major cause of immunocompromised status and opportunistic infections leading to transplanted organ failure. During the last decade, polyomavirus virus associated nephropathy (PVAN) has been the major cause of a serious complication allograft failure in these patients. The prevalence of PVAN has increased from 1% to 10 % leading to loss of transplanted organ in 30% to 80% of cases. Viremia precedes PVAN, and in the absence of specific antiviral drugs, early detection of disease and modification/reduction of immunosuppressive regimen currently is the cornerstone of therapy. Although PVAN nephropathy is well documented, it has not been thoroughly investigated in nonrenal and/or multiple organ transplantation; such are simultaneous kidney and pancreas transplantation (SPKT). In these specific conditions the diagnosis and therapy of PVAN can be even more challenging problem. We report a 32 years old patient who presented with PVAN 6 month after SPKT due to diabetic nephropathy. He received induction immunosuppression which included IL-2 antibody (daclizumab), steroids, mycophenolate mofetil and tacrolimus. Diagnosis was made on the basis of protocol cytologic study in urine, examining Decoy cell and confirmed by histological examination of renal biopsy which revealed viral inclusions on light microscopy as well as positive immunohistochemistry analysis. Patient was treated with reduced immunosuppressive regimen, both tacrolimus and mycophenolate mofetil with continuation of small dose of prednisone. At two years follow up, patient has preserved kidney and pancreas function with estimated glomerular filtration rate of 84 ml/ min and no signs of PVAN on his 2 year protocol kidney biopsy. sonja.gracin@gmail.com
Clinical Cytology - Posters CASE REPORT OF A PATIENT WITH PERITONEAL AND OMENTAL LYMPHOMA INFILATRATION AND ASCITES POSITIVE FOR LYMPHOMA CELLS, FOLLOWING A RELAPSE OF SPLENIC MARGINAL ZONE LYMPHOMA (SMZL) Gredelj Šimec Nj1 , Ropar S2 , Baškot A3 , Dejanović M1 1 Department od Internal Medicine 2 Department of Cytology 3 Department of Radiology G.H. Karlovac, Croatia We have presented a patient with marginal NHL of Splenic type. The disease was manifested in splenomegaly and leukocytosis, without lymphadenopathy. The diagnose was set by immunocytochemical and immunophenotypic assessment of the peripheral blood. The patient was treated with 8 cycles of chemotherapy following the COP scheme in combination with Rituximab. Following treatment, complete remission was achieved. 18 months later, the disease was manifested in splenomegaly, leukocytosis with 9% atypical lymphatic cells in the peripheral blood, multiple masses of solid peritoneal and omental tumours in size up to 6.5 cm, same as massive ascites with cytologically proven lymphoma cells. njetocka.gredelj@zg.t-com.hr 121 4 th Croatian Congress of Clinical Cytology / 1 st Croatian Symposium of Analytical Cytology / 2 nd Croatian Symposium of Cytotechnology
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Final programme and abstract book
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UTORAK, 13.10.2009. SRIJEDA, 14.10.
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4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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